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Protein Overview: Tsf3-PA

General Information:
Name(s) found: Tsf3-PA / FBpp0086274 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • The gene Transferrin 3 is referred to in FlyBase by the symbol Dmel\Tsf3 (CG3666, FBgn0034094). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:12114031..12117379. It has the cytological map location 52F11. It is reported to have molecular function</span>: iron ion transmembrane transporter activity. There is experimental evidence that it is involved in the biological process</span>: response to bacterium. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 714 amino acids

    Gene Ontology:
    Cellular Component: extracellular region [IEA]
    Biological Process: cellular iron ion homeostasis [IEA]
    response to bacterium [IEP]
    iron ion transport [IEA]
    Molecular Function: iron ion transmembrane transporter activity [NAS]
    ferric iron binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQWLTLILVG LFASFLSISM CVAVQPPDDG KLRVCVVESR GVYRKTPKFC PLLEAKSNIE  60
   61 CVIGVDRLDC VRRIHKGTAH FGVLTSEDLV AARWASVEIL VASELRSHES HFEYEIVAVV 120
  121 DNHANIHTVH DLRGARLCHP GYGLGNHWTE VLANYFEAAM VSKTCDPEMT VTEDRIASTA 180
  181 KYFGPSCKAG PWVPDPKQDR ILKNRYPSLC EMCYEPDSCD QTDKHWGRRG ALYCLTSGGG 240
  241 NVAWARLDDV RSHFGFSGIP AQSNPSDFSY LCPDGHLQPL NASQPCVWVA KPWPVVAARR 300
  301 SHAAQVQRLV TGLNHDEPDS WQNALLSLLE TYHVFTVPLD NVIAIDDYLD QATAFQSAYS 360
  361 FPECNPPRSI VFCTTSIIQH IKCSWLQEAS QVYGVQPNIQ CVRTMDEQQC LDNTKFKETD 420
  421 VVLVDQEMRV KAQRDYNLVP LLYEFAADMH DRYVTIALVH KDAKFESFRD LKGARACLPS 480
  481 FEGAAHLSVQ ETIVNATGKV QSLHSYFHRD SCLWNLQSGR KCPLHYQGDE GALRCLSEGA 540
  541 DVAFLSSDVY KKYVVGNLTS NWLTPGNHKD FRVLCPYGGI EKRSNFEYCY LHWTTRGHLM 600
  601 THNSSLTRRN EIYNSLRDMD QLFGRKYKSE TRPFTLYGIF DKRNNVLFRD DTDGLLGLQE 660
  661 LHRDNAKRVM EHIYDRYANT QYYRNFDESG AMKSSHNLWI LLVCLLFVVG QPFG

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..714] PSI-BLAST 164.0 No description for 2havA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • substrate-specific transmembrane transporter activity
    		•  4.68307627076676 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  4.22641590829276 bayes_pls_golite062009
  • transporter activity
    		•  3.92658561501282 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  3.71430307970333 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  3.45211068541539 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  3.34421502810243 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  3.33883206510679 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  3.33572158012752 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  3.31947078781945 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  3.3164655425684 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  3.3159417475856 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  3.25041295044206 bayes_pls_golite062009
  • ferric iron transmembrane transporter activity
    		•  3.02947711384338 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.86948925100516 bayes_pls_golite062009
  • transition metal ion transmembrane transporter activity
    		•  2.70046464278671 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  2.65558937563899 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of ions
    		•  2.62312131886704 bayes_pls_golite062009
  • ATPase activity
    		•  2.40029628345531 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  2.3103850882599 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  2.24148099938567 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.2348608319417 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  2.21542452486366 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  2.21260159167253 bayes_pls_golite062009
  • binding
    		•  2.20249180444367 bayes_pls_golite062009
  • anion transmembrane transporter activity
    		•  2.18878964063845 bayes_pls_golite062009
  • inorganic anion transmembrane transporter activity
    		•  2.17975065094225 bayes_pls_golite062009
  • amine binding
    		•  1.86046575344087 bayes_pls_golite062009
  • anion transmembrane-transporting ATPase activity
    		•  1.78891156577149 bayes_pls_golite062009
  • iron ion transmembrane transporter activity
    		•  1.73960512999321 bayes_pls_golite062009
  • di-, tri-valent inorganic cation transmembrane transporter activity
    		•  1.64195930233359 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.26257581527945 bayes_pls_golite062009
  • signal transducer activity
    		•  1.26257581527945 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.25229780869406 bayes_pls_golite062009
  • transcription factor activity
    		•  1.03879366009824 bayes_pls_golite062009
  • DNA binding
    		•  0.96695731167457 bayes_pls_golite062009
  • hydrolase activity
    		•  0.825775589802563 bayes_pls_golite062009
  • receptor activity
    		•  0.81769038251366 bayes_pls_golite062009
  • protein binding
    		•  0.782435650956845 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.748932877801675 bayes_pls_golite062009
  • molybdate transmembrane-transporting ATPase activity
    		•  0.480504240439005 bayes_pls_golite062009
  • molybdate ion transmembrane transporter activity
    		•  0.480504240439005 bayes_pls_golite062009
  • amine transmembrane transporter activity
    		•  0.372828805396439 bayes_pls_golite062009
  • ferric iron binding
    		•  0.336741291902441 bayes_pls_golite062009
  • iron ion binding
    		•  0.315474089640639 bayes_pls_golite062009
  • transition metal ion binding
    		•  0.263323904110968 bayes_pls_golite062009
  • peptide binding
    		•  0.0846871934192293 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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