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Protein Overview: FBpp0309018, dup-PA

General Information:
Name(s) found: FBpp0309018 [FlyBase]
dup-PA / FBpp0086519 [FlyBase]
Description(s) found:
Found 29 descriptions.
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  • type=protein; loc=2R:complement(11264441..11265926,11267062..11267726,11267824..11267904); ID=FBpp0309018; name=dup-PB; parent=FBgn0000996,FBtr0339999; dbxref=FlyBase:FBpp0309018,FlyBase_Annotation_IDs:CG8171-PB; MD5=22560b4e2a1f971f8b10db7e00b0597a; length=743; release=r5.56; species=Dmel; [FlyBase]
  • The gene double parked is referred to in FlyBase by the symbol Dmel\dup (CG8171, FBgn0000996). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:11264124..11268465. It has the cytological map location 51F11. It is reported to have molecular function</span>: DNA binding. There is experimental evidence that it is involved in the biological process</span>: chorion-containing eggshell formation; DNA replication checkpoint; DNA replication; antimicrobial humoral response; DNA endoreduplication. 18 alleles are reported. The phenotypes of these alleles are annotated with: eye disc; mitotic cell cycle; follicle cell; imaginal disc; S phase; cycle 16 embryo; mitotic metaphase. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 743 amino acids

    Gene Ontology:
    Cellular Component: replication fork [IDA]
    nucleus [IDA]
    cytoplasm [IDA]
    nuclear origin of replication recognition complex [IDA][NAS]
    Biological Process: DNA replication checkpoint [IMP]
    eggshell chorion gene amplification [TAS]
    DNA replication [IMP][TAS]
    DNA-dependent DNA replication [NAS]
    DNA endoreduplication [IMP]
    antimicrobial humoral response [IMP]
    chorion-containing eggshell formation [IMP]
    Molecular Function: DNA binding [NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAQPSVAAFF TNRKRAALDD AISIKNRRLV EPAETVSPAS APSQLPAGDQ DADLDTLKAA  60
   61 ATGMRTRSGR TARLIVTAAQ ESKKKTPAAA KMEPHIKQPK LVQFIKKGTL SPRKQAQSSK 120
  121 LDEEELQQSS AISEHTPKVN FTITSQQNAD NVQRGLRTPT KQILKDASPI KADLRRQLTF 180
  181 DEVKTKVSRS AKLQELKAVL ALKAALEQKR KEQEERNRKL RDAGPSPSKS KMSVQLKEFD 240
  241 TIELEVLISP LKTFKTPTKI PPPTPDKHEL MSPRHTDVSK RLLFSPAKNG SPVKLVEVPA 300
  301 YKRYASLVES SRAGQLPLPY KYRHLLDVFK GLDSVVAMFH NRKETITFKK LKPAVQRMLR 360
  361 KNFTETHLAQ IKHIYPDAFI FSQVKTRNFG SVSKADYFQL IIAPNVEPLP EQQQSEKPQH 420
  421 FTKINEDDVL ASAQSTSMNP HVMTARMQRF QSLLLDRAMR AHDQFLRSQD PPIIIEKALT 480
  481 RWHPQFDLES CPEVELSPLP QPPNVEKYSS AKDILSTARN LFNCATPMER AMDRYEAKLE 540
  541 SEKQQAAESN KKTEEQQAGE VTRTSTAIQT SQEVPGISGS SKNPTVPETT NQTETAKPTV 600
  601 KDCTVPDASS NLLKGLPKSL IEKIRAKQAA KALEAMTRRP SQDQEATKYS RLPELARHLR 660
  661 NVFVTERKGV LTLEVIIKKI QNSFRANLTP QEIEAHLKLL AKELPSWASF HEVRKTMYLK 720
  721 VAKDMDMNKI IEKLESVANA KSN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..158] MSA 2.184995 View MSA. No confident structure predictions are available.
    2 View Details [159..298] deduced N/A No confident structure predictions are available.
    3 View Details [299..580] PSI-BLAST 13.221849 Strucure of Geminin-Cdt1 complex
    4 View Details [581..743] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • transcription regulator activity
    		•  5.29569167054278 bayes_pls_golite062009
  • DNA binding
    		•  4.90756541371868 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.69183445184264 bayes_pls_golite062009
  • transcription factor activity
    		•  4.14166958134441 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.67170893636603 bayes_pls_golite062009
  • binding
    		•  3.52874320222492 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.48053910222825 bayes_pls_golite062009
  • transcription activator activity
    		•  2.29614125067822 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.48055533524841 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.913018999939773 bayes_pls_golite062009
  • transcription factor binding
    		•  0.83705247708153 bayes_pls_golite062009
  • specific transcriptional repressor activity
    		•  0.784141484679161 bayes_pls_golite062009
  • protein binding
    		•  0.753698599635855 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.697234220778482 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.300899564141452 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.195360629877364 bayes_pls_golite062009
  • structural molecule activity
    		•  0.111941063082739 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.94

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle