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Protein Overview: SMC2-PA

General Information:
Name(s) found: SMC2-PA / FBpp0086591 [FlyBase]
Description(s) found:
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  • gi|7303132|gb|AAF58197.1| SMC2 [Drosophila melanogaster] [NCBI NR]
  • gi|5815438|gb|AAD52673.1|AF179287_1 SMC2 [Drosophila melanogaster] [NCBI NR]
  • gi|19922276|ref|NP_610995.1| SMC2 [Drosophila melanogaster] [NCBI NR]
  • The gene SMC2 is referred to in FlyBase by the symbol Dmel\SMC2 (CG10212, FBgn0027783). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:10736094..10740155. It has the cytological map location 51C5. Based on sequence similarity, it is predicted to have molecular function</span>: DNA binding. There is experimental evidence that it is involved in the biological process</span>: mitotic chromosome condensation; mitotic spindle organization. 7 alleles are reported. The phenotype of these alleles is annotated with: larval brain. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • >CG10212-PA translation from_gene[CG10212 SMC2 FBgn0027783] seq_release:3 mol_weight=134337 cds_boundaries:(2R:9,912,401..9,916,280[-]) aa_length:1179 transcript_info:[CG10212-RA seq_release:3] gene_info:[gene symbol:SMC2 FBgn0027783 gene_boundaries:(2 [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9V450) SMC2 protein [DrosMelano7227.FASTAC.txt]
  • (AE003813) SMC2 gene product [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG10212-PA [Drosophila melanogaster]gi|5815438|gb|AAD52673.1| SMC2 [Drosophila melanogaster]gi|19922276|ref|NP_610995.1| CG10212-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=2R:complement(10736177..10737614,10737668..10737861,10737918..10738187,10738245..10738672,10738729..10739458,10739521..10739832,10739892..10740059); ID=FBpp0086591; name=SMC2-PA; parent=FBgn0027783,FBtr0087461; dbxref=FlyBase:FBpp0086591 [fly-100309-contam.fasta]
  • SMC2 CG10212-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG10212-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • SMC2 [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=2R:complement(10736177..10737614,10737668..10737861,10737918..10738187,10738245..10738672,10738729..10739458,10739521..10739832,10739892..10740059); ID=FBpp0086591; name=SMC2-PA; parent=FBgn0027783,FBtr0087461; dbxref=FlyBase:FBpp0086591,FlyBase_Annotation_IDs:CG10212-PA,GB_protein:AAF58197.1,REFSEQ:NP_610995,GB_protein:AAF58197; MD5=3a04748e6b2ab8c9ae791d06503589c6; length=1179; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=2R:complement(10736177..10737614,10737668..10737861,10737918..10738187,10738245..10738672,10738729..10739458,10739521..10739832,10739892..10740059); ID=FBpp0086591; name=SMC2-PA; parent=FBgn0027783,FBtr0087461; dbxref=FlyBase:FBpp0086591,FlyBase_Annotation_IDs:CG10212-PA,GB_protein:AAF58197.1,REFSEQ:NP_610995,GB_protein:AAF58197; MD5=3a04748e6b2ab8c9ae791d06503589c6; length=1179; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • SMC2 OS=Drosophila melanogaster GN=SMC2 PE=2 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=2R:complement(10736177..10737614,10737668..10737861,10737918..10738187,10738245..10738672,10738729..10739458,10739521..10739832,10739892..10740059); ID=FBpp0086591; name=SMC2-PA; parent=FBgn0027783,FBtr0087461; dbxref=FlyBase:FBpp0086591,FlyBase_Annotation_IDs:CG10212-PA,GB_protein:AAF58197.1,REFSEQ:NP_610995,GB_protein:AAF58197,FlyMine:FBpp0086591,modMine:FBpp0086591; MD5=3a04748e6b2ab8c9ae791d06503589c6; length=1179; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • Structural maintenance of chromosomes protein OS=Drosophila melanogaster GN=SMC2 PE=2 SV=1 [UniProt_D_Melanogaster_07132012_07-13-2012_reversed.fasta]
  • type=protein; loc=2R:complement(join(14852387..14852554,14852016..14852327,14851224..14851953,14850740..14851167,14850413..14850682,14850163..14850356,14848672..14850109)); ID=FBpp0086591; name=SMC2-PA; parent=FBgn0027783,FBtr0087461; dbxref=FlyBase:FBpp0086591,FlyBase_Annotation_IDs:CG10212-PA,GB_protein:AAF58197.1,REFSEQ:NP_610995,GB_protein:AAF58197,FlyMine:FBpp0086591,modMine:FBpp0086591; MD5=3a04748e6b2ab8c9ae791d06503589c6; length=1179; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=2R:complement(join(14852387..14852554,14852016..14852327,14851224..14851953,14850740..14851167,14850413..14850682,14850163..14850356,14848672..14850109)); ID=FBpp0086591; name=SMC2-PA; parent=FBgn0027783,FBtr0087461; dbxref=FlyBase:FBpp0086591,FlyBase_Annotation_IDs:CG10212-PA,GB_protein:AAF58197.1,REFSEQ:NP_610995,GB_protein:AAF58197,FlyMine:FBpp0086591,modMine:FBpp0086591; MD5=3a04748e6b2ab8c9ae791d06503589c6; length=1179; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • Structural maintenance of chromosomes protein OS=Drosophila melanogaster GN=SMC2 PE=1 SV=1 [DROME.fasta.20160308]
  • FBpp0086591 type=protein; loc=2R:complement(join(14852387..14852554,14852016..14852327,14851224..14851953,14850740..14851167,14850413..14850682,14850163..14850356,14848672..14850109)); ID=FBpp0086591; name=SMC2-PA; parent=FBgn0027783,FBtr0087461; dbxref=FlyBase:FBpp0086591,FlyBase_Annotation_IDs:CG10212-PA,GB_protein:AAF58197.1,REFSEQ:NP_610995,GB_protein:AAF58197,FlyMine:FBpp0086591,modMine:FBpp0086591; MD5=3a04748e6b2ab8c9ae791d06503589c6; length=1179; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=2R:complement(join(14852387..14852554,14852016..14852327,14851224..14851953,14850740..14851167,14850413..14850682,14850163..14850356,14848672..14850109)); ID=FBpp0086591; name=SMC2-PA; parent=FBgn0027783,FBtr0087461; dbxref=FlyBase:FBpp0086591,FlyBase_Annotation_IDs:CG10212-PA,GB_protein:AAF58197.1,REFSEQ:NP_610995,GB_protein:AAF58197,UniProt/TrEMBL:Q7KK96,FlyMine:FBpp0086591,modMine:FBpp0086591; MD5=3a04748e6b2ab8c9ae791d06503589c6; length=1179; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 1179 amino acids

    Gene Ontology:
    Cellular Component: cohesin complex [ISS]
    condensin complex [ISS][NAS]
    Biological Process: sister chromatid cohesion [ISS]
    mitotic chromosome condensation [IMP]
    mitotic spindle organization [IMP]
    Molecular Function: DNA binding [ISS]
    ATP binding [IEA]
    protein binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYVKKLVLDG FKSYGRRTEI EGFDPEFTAI TGLNGSGKSN ILDSICFVLG ISNLQNVRAS  60
   61 ALQDLVYKNG QAGITKATVT IVFDNTNPAQ CPQGYEKCRE ISVTRQVVVG GKNKFLINGK 120
  121 LVQNKKVQDF FCSIQLNVNN PNFLIMQGKI QQVLNMKPKE VLSMVEEAAG TSQYKTKRDA 180
  181 TKTLIEKKET KVRETKVLLD EEVLPKLVKL RQERSAYQEY QKICRDIDFL IRIHISAKYL 240
  241 KQCETLKTVE ANEHKIEDRI ANCKATHAKN LAEVESIENS VKEMQQQIDA EMGGSIKNLE 300
  301 TQLSAKRALE ATATGSLKAA QGTIQQDEKK IRMASKNIED DERALAKKEA DMAKVQGEFE 360
  361 SLKEADARDS KAYEDAQKKL EAVSQGLSTN ENGEASTLQE QLIVAKEQFS EAQTTIKTSE 420
  421 IELRHTRGVL KQREGETQTN DAAYVKDKKL HDQLVVEIKN LERQLQSLDY EGGHFEKLKQ 480
  481 RRNDLHMRKR DLKRELDRCN ASRYDLQYQD PEPNFDRRKV RGLVGKLFQV KDMQNSMALV 540
  541 QTAGGSLYSY VTDDDVTSKK ILQRGNLQRR VTLIPINKIQ SGSLNRNVVE YAQNKVGAEN 600
  601 VQWAMSLIDY DRYYEPVMKF CFGGTLICKD LIVAKQISYD PRINCRSVTL EGDVVDPHGT 660
  661 VSGGAAPKGA NVLEELHAIK QIEKEYREID SEIAQVEKQI ASIENQALAF NKMKENLDLR 720
  721 QHELTMCENR LAQTTFQQNQ AEIEEMRERV KTLEQQIIDS REKQKTSQAK IVDIEAKLAD 780
  781 AKGYRERELN AATNEIKVTK QRAEKSRANW KKREQEFETL QLEITELQKS IETAKKQHQE 840
  841 MIDNLEKFKA ELDALKVNSS SAASEVTELE QAIKEQKDKL RDQNKEMRNQ LVKKEKMLKE 900
  901 NQEIELEVKK KENEQKKISS DAKEAKKRME ALEAKYPWIP EEKNCFGMKN TRYDYSKEDP 960
  961 HEAGNKLAKM QEKKDKMERT LNMNAIMVLD REEENFKETE RRRNIVAMDK EKIKKIIVKM1020
 1021 DEEEQDQLNK AATEVNTNFS GIFSSLLPGA EAKLNPVHTN GCLTGLEIKV GFNGIWKESL1080
 1081 GELSGGQKSL VALSLVLAML KFSPAPLYIL DEVDAALDMS HTQNIGSMLK QHFTNSQFLI1140
 1141 VSLKDGLFNH ANVLFRTLFE EGVSTITRQV SRQATTNKR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..176] PSI-BLAST 37.30103 Structural biochemistry of ATP-driven dimerization and DNA stimulated activation of SMC ATPases.
    2 View Details [177..495] FFAS03 2.28 No description for 2i1jA was found.
    3 View Details [496..679] FFAS03 4.47 Smc hinge domain
    4 View Details [680..1018] FFAS03 2.83 Tropomyosin
    5 View Details [1019..1179] PSI-BLAST 16.154902 Structural biochemistry of ATP-driven dimerization and DNA stimulated activation of SMC ATPases.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • motor activity
    		•  2.79327761685782 bayes_pls_golite062009
  • microtubule motor activity
    		•  2.74365461017633 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  2.72462789867829 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  2.69246499202248 bayes_pls_golite062009
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.61582393123755 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  2.59641929642359 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  2.59333672868803 bayes_pls_golite062009
  • DNA helicase activity
    		•  2.2817164193758 bayes_pls_golite062009
  • transporter activity
    		•  2.17383908004663 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.11222585187695 bayes_pls_golite062009
  • ATPase activity
    		•  2.11122403732968 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.02444700826552 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  1.8908019270286 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  1.88455339138556 bayes_pls_golite062009
    		• 1.75135117904448 bayes_pls_golite062009
  • DNA binding
    		•  1.72568209621547 bayes_pls_golite062009
  • helicase activity
    		•  1.70242731830224 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.63193306273479 bayes_pls_golite062009
  • RNA helicase activity
    		•  1.42791449104435 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.40488517180956 bayes_pls_golite062009
  • RNA-dependent ATPase activity
    		•  1.39335733374328 bayes_pls_golite062009
  • ATP-dependent RNA helicase activity
    		•  1.36724390116598 bayes_pls_golite062009
  • hydrolase activity
    		•  1.35268825531078 bayes_pls_golite062009
  • protein-DNA loading ATPase activity
    		•  1.29640539057136 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.2539059700735 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  1.19311444180077 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  1.19311444180077 bayes_pls_golite062009
  • DNA clamp loader activity
    		•  1.12431517057397 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  1.117585097627 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • tubulin binding
    		•  0.979946830272106 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.97700154207756 bayes_pls_golite062009
  • microtubule binding
    		•  0.907162506177187 bayes_pls_golite062009
  • actin binding
    		•  0.883285269827407 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.725611289205392 bayes_pls_golite062009
  • nucleotide binding
    		•  0.717697610309727 bayes_pls_golite062009
  • RNA binding
    		•  0.715902454627085 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.713814218071151 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.713752628021599 bayes_pls_golite062009
  • guanyl nucleotide binding
    		•  0.656009904481476 bayes_pls_golite062009
  • guanyl ribonucleotide binding
    		•  0.64416740142962 bayes_pls_golite062009
  • GTP binding
    		•  0.643084645864898 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.608058786636536 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  0.568457189190858 bayes_pls_golite062009
  • transcription factor activity
    		•  0.567932466447757 bayes_pls_golite062009
  • kinetochore binding
    		•  0.534490088080411 bayes_pls_golite062009
  • recombinase activity
    		•  0.45851158693664 bayes_pls_golite062009
  • GTPase activity
    		•  0.437665353870877 bayes_pls_golite062009
  • centromeric DNA binding
    		•  0.322818640526369 bayes_pls_golite062009
  • mismatched DNA binding
    		•  0.31144582840038 bayes_pls_golite062009
  • four-way junction helicase activity
    		•  0.26252931460003 bayes_pls_golite062009
  • ATP binding
    		•  0.19169045543599 bayes_pls_golite062009
  • exodeoxyribonuclease V activity
    		•  0.185603938981231 bayes_pls_golite062009
  • protein binding
    		•  0.170837278876362 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.165732470448462 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.162060759063149 bayes_pls_golite062009
  • dynein binding
    		•  0.150959629961177 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.114463153989353 bayes_pls_golite062009
  • microfilament motor activity
    		•  0.10236059675512 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.081265446432119 bayes_pls_golite062009
  • 3'-5' DNA helicase activity
    		•  0.0769112340058804 bayes_pls_golite062009
    2 No functions predicted.
    3
    Term Confidence Notes
  • binding
    		•  2.91859588671053 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.85809295645854 bayes_pls_golite062009
  • DNA binding
    		•  1.71700314893388 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.23709457794394 bayes_pls_golite062009
  • protein binding
    		•  1.02696508439754 bayes_pls_golite062009
  • DNA secondary structure binding
    		•  1.02239440262162 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.999818859536395 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.558475595998159 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.299763949828861 bayes_pls_golite062009
  • catalytic activity
    		•  0.265320175609019 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.248383422632029 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.235472660839816 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.233111707634177 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.154578921841996 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.108132520107784 bayes_pls_golite062009
  • ATPase activity
    		•  0.08869715759545 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle