YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Structure Prediction Details

Protein: SMC2-PA
Organism: Drosophila melanogaster
Length: 1179 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



[What does the above image mean?]


[Show Ginzu Version Information]


Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SMC2-PA.

Description E-value Query
Range		 Subject
Range
gi|109110711, gi... - gi|109110711|ref|XP_001110295.1| PREDICTED: structural maintenance of chromosomes 2-like 1 isoform 6...
 295.0 [0..1] [1170..1]

Back

Predicted Domain #1
Region A:
Residues: [1-176] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYVKKLVLDG FKSYGRRTEI EGFDPEFTAI TGLNGSGKSN ILDSICFVLG ISNLQNVRAS  60
   61 ALQDLVYKNG QAGITKATVT IVFDNTNPAQ CPQGYEKCRE ISVTRQVVVG GKNKFLINGK 120
  121 LVQNKKVQDF FCSIQLNVNN PNFLIMQGKI QQVLNMKPKE VLSMVEEAAG TSQYKT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 37.30103
Match: 1xewX
Description: Structural biochemistry of ATP-driven dimerization and DNA stimulated activation of SMC ATPases.
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
motor activity 2.79327761685782 bayes_pls_golite062009
microtubule motor activity 2.74365461017633 bayes_pls_golite062009
DNA-dependent ATPase activity 2.72462789867829 bayes_pls_golite062009
nucleoside-triphosphatase activity 2.69246499202248 bayes_pls_golite062009
binding 2.64537357529343 bayes_pls_golite062009
pyrophosphatase activity 2.61582393123755 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 2.59641929642359 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 2.59333672868803 bayes_pls_golite062009
DNA helicase activity 2.2817164193758 bayes_pls_golite062009
transporter activity 2.17383908004663 bayes_pls_golite062009
nucleic acid binding 2.11222585187695 bayes_pls_golite062009
ATPase activity 2.11122403732968 bayes_pls_golite062009
transmembrane transporter activity 2.02444700826552 bayes_pls_golite062009
ATPase activity, coupled 1.8908019270286 bayes_pls_golite062009
ATP-dependent DNA helicase activity 1.88455339138556 bayes_pls_golite062009
1.75135117904448 bayes_pls_golite062009
DNA binding 1.72568209621547 bayes_pls_golite062009
helicase activity 1.70242731830224 bayes_pls_golite062009
transcription regulator activity 1.63193306273479 bayes_pls_golite062009
RNA helicase activity 1.42791449104435 bayes_pls_golite062009
cytoskeletal protein binding 1.40488517180956 bayes_pls_golite062009
RNA-dependent ATPase activity 1.39335733374328 bayes_pls_golite062009
ATP-dependent RNA helicase activity 1.36724390116598 bayes_pls_golite062009
hydrolase activity 1.35268825531078 bayes_pls_golite062009
protein-DNA loading ATPase activity 1.29640539057136 bayes_pls_golite062009
structure-specific DNA binding 1.2539059700735 bayes_pls_golite062009
purine NTP-dependent helicase activity 1.19311444180077 bayes_pls_golite062009
ATP-dependent helicase activity 1.19311444180077 bayes_pls_golite062009
DNA clamp loader activity 1.12431517057397 bayes_pls_golite062009
double-stranded DNA binding 1.117585097627 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
tubulin binding 0.979946830272106 bayes_pls_golite062009
substrate-specific transporter activity 0.97700154207756 bayes_pls_golite062009
microtubule binding 0.907162506177187 bayes_pls_golite062009
actin binding 0.883285269827407 bayes_pls_golite062009
purine nucleotide binding 0.725611289205392 bayes_pls_golite062009
nucleotide binding 0.717697610309727 bayes_pls_golite062009
RNA binding 0.715902454627085 bayes_pls_golite062009
purine ribonucleotide binding 0.713814218071151 bayes_pls_golite062009
ribonucleotide binding 0.713752628021599 bayes_pls_golite062009
guanyl nucleotide binding 0.656009904481476 bayes_pls_golite062009
guanyl ribonucleotide binding 0.64416740142962 bayes_pls_golite062009
GTP binding 0.643084645864898 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.608058786636536 bayes_pls_golite062009
single-stranded DNA binding 0.568457189190858 bayes_pls_golite062009
transcription factor activity 0.567932466447757 bayes_pls_golite062009
kinetochore binding 0.534490088080411 bayes_pls_golite062009
recombinase activity 0.45851158693664 bayes_pls_golite062009
GTPase activity 0.437665353870877 bayes_pls_golite062009
centromeric DNA binding 0.322818640526369 bayes_pls_golite062009
mismatched DNA binding 0.31144582840038 bayes_pls_golite062009
four-way junction helicase activity 0.26252931460003 bayes_pls_golite062009
ATP binding 0.19169045543599 bayes_pls_golite062009
exodeoxyribonuclease V activity 0.185603938981231 bayes_pls_golite062009
protein binding 0.170837278876362 bayes_pls_golite062009
adenyl ribonucleotide binding 0.165732470448462 bayes_pls_golite062009
adenyl nucleotide binding 0.162060759063149 bayes_pls_golite062009
dynein binding 0.150959629961177 bayes_pls_golite062009
active transmembrane transporter activity 0.114463153989353 bayes_pls_golite062009
microfilament motor activity 0.10236059675512 bayes_pls_golite062009
ion transmembrane transporter activity 0.081265446432119 bayes_pls_golite062009
3'-5' DNA helicase activity 0.0769112340058804 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [177-495] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KRDATKTLIE KKETKVRETK VLLDEEVLPK LVKLRQERSA YQEYQKICRD IDFLIRIHIS  60
   61 AKYLKQCETL KTVEANEHKI EDRIANCKAT HAKNLAEVES IENSVKEMQQ QIDAEMGGSI 120
  121 KNLETQLSAK RALEATATGS LKAAQGTIQQ DEKKIRMASK NIEDDERALA KKEADMAKVQ 180
  181 GEFESLKEAD ARDSKAYEDA QKKLEAVSQG LSTNENGEAS TLQEQLIVAK EQFSEAQTTI 240
  241 KTSEIELRHT RGVLKQREGE TQTNDAAYVK DKKLHDQLVV EIKNLERQLQ SLDYEGGHFE 300
  301 KLKQRRNDLH MRKRDLKRE

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.28
Match: 2i1jA
Description: No description for 2i1jA was found.

Predicted Domain #3
Region A:
Residues: [496-679] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LDRCNASRYD LQYQDPEPNF DRRKVRGLVG KLFQVKDMQN SMALVQTAGG SLYSYVTDDD  60
   61 VTSKKILQRG NLQRRVTLIP INKIQSGSLN RNVVEYAQNK VGAENVQWAM SLIDYDRYYE 120
  121 PVMKFCFGGT LICKDLIVAK QISYDPRINC RSVTLEGDVV DPHGTVSGGA APKGANVLEE 180
  181 LHAI

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 4.47
Match: 1gxlA
Description: Smc hinge domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.91859588671053 bayes_pls_golite062009
nucleic acid binding 1.85809295645854 bayes_pls_golite062009
DNA binding 1.71700314893388 bayes_pls_golite062009
structure-specific DNA binding 1.23709457794394 bayes_pls_golite062009
protein binding 1.02696508439754 bayes_pls_golite062009
DNA secondary structure binding 1.02239440262162 bayes_pls_golite062009
double-stranded DNA binding 0.999818859536395 bayes_pls_golite062009
protein heterodimerization activity 0.558475595998159 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.299763949828861 bayes_pls_golite062009
catalytic activity 0.265320175609019 bayes_pls_golite062009
pyrophosphatase activity 0.248383422632029 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.235472660839816 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.233111707634177 bayes_pls_golite062009
sequence-specific DNA binding 0.154578921841996 bayes_pls_golite062009
protein dimerization activity 0.108132520107784 bayes_pls_golite062009
ATPase activity 0.08869715759545 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [680-1018] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KQIEKEYREI DSEIAQVEKQ IASIENQALA FNKMKENLDL RQHELTMCEN RLAQTTFQQN  60
   61 QAEIEEMRER VKTLEQQIID SREKQKTSQA KIVDIEAKLA DAKGYREREL NAATNEIKVT 120
  121 KQRAEKSRAN WKKREQEFET LQLEITELQK SIETAKKQHQ EMIDNLEKFK AELDALKVNS 180
  181 SSAASEVTEL EQAIKEQKDK LRDQNKEMRN QLVKKEKMLK ENQEIELEVK KKENEQKKIS 240
  241 SDAKEAKKRM EALEAKYPWI PEEKNCFGMK NTRYDYSKED PHEAGNKLAK MQEKKDKMER 300
  301 TLNMNAIMVL DREEENFKET ERRRNIVAMD KEKIKKIIV

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.83
Match: 1c1gA
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [1019-1179] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KMDEEEQDQL NKAATEVNTN FSGIFSSLLP GAEAKLNPVH TNGCLTGLEI KVGFNGIWKE  60
   61 SLGELSGGQK SLVALSLVLA MLKFSPAPLY ILDEVDAALD MSHTQNIGSM LKQHFTNSQF 120
  121 LIVSLKDGLF NHANVLFRTL FEEGVSTITR QVSRQATTNK R

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.154902
Match: 1xexB
Description: Structural biochemistry of ATP-driven dimerization and DNA stimulated activation of SMC ATPases.
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle