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Protein Overview: AGO1-PB

General Information:
Name(s) found: AGO1-PB / FBpp0086740 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene Argonaute-1 is referred to in FlyBase by the symbol Dmel\AGO1 (CG6671, FBgn0026611). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:9834047..9845594. It has the cytological map location 50C9-50C17. There is experimental evidence that it has the molecular function</span>: enzyme binding; protein binding; miRNA binding. There is experimental evidence that it is involved in the biological process</span>: RNA interference; mRNA catabolic process; production of miRNAs involved in gene silencing by miRNA; production of siRNA involved in RNA interference; mRNA cleavage involved in gene silencing by miRNA; targeting of mRNA for destruction involved in RNA interference; gene silencing by miRNA; segment polarity determination; cellularization; chromatin silencing. 42 alleles are reported. The phenotypes of these alleles are annotated with: eye; macrochaeta; anterior crossvein; imaginal disc. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 950 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA]
    perinuclear region of cytoplasm [IDA]
    cytoplasm [IDA]
    RNA-induced silencing complex [ISS]
    eukaryotic translation initiation factor 2 complex [ISS]
    Biological Process: synapse assembly [TAS]
    gene silencing by miRNA [IMP][NAS]
    production of miRNAs involved in gene silencing by miRNA [IMP]
    segment polarity determination [IGI]
    chromatin silencing [IMP]
    production of siRNA involved in RNA interference [IMP]
    mRNA cleavage involved in gene silencing by miRNA [IDA][IMP]
    mRNA catabolic process [IGI][IMP]
    RNA interference [IGI][TAS]
    cellularization [IGI]
    targeting of mRNA for destruction involved in RNA interference [IMP]
    Molecular Function: miRNA binding [IDA]
    translation initiation factor activity [ISS]
    protein binding [IPI]
    enzyme binding [IPI]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYPVGQQSQW TPSPTRPQSP SQAQTSFDTL TSPPAPGSSV NPTAVTSPSA QNVAAGGATV  60
   61 AGAAATAAQV ASALGATTGS VTPAIATATP ATQPDMPVFT CPRRPNLGRE GRPIVLRANH 120
  121 FQVTMPRGYV HHYDINIQPD KCPRKVNREI IETMVHAYSK IFGVLKPVFD GRNNLYTRDP 180
  181 LPIGNERLEL EVTLPGEGKD RIFRVTIKWQ AQVSLFNLEE ALEGRTRQIP YDAILALDVV 240
  241 MRHLPSMTYT PVGRSFFSSP EGYYHPLGGG REVWFGFHQS VRPSQWKMML NIDVSATAFY 300
  301 KAQPVIDFMC EVLDIRDINE QRKPLTDSQR VKFTKEIKGL KIEITHCGQM RRKYRVCNVT 360
  361 RRPAQMQSFP LQLENGQTVE CTVAKYFLDK YRMKLRYPHL PCLQVGQEHK HTYLPLEVCN 420
  421 IVAGQRCIKK LTDMQTSTMI KATARSAPDR EREINNLVKR ADFNNDSYVQ EFGLTISNSM 480
  481 MEVRGRVLPP PKLQYGGRVS TGLTGQQLFP PQNKVSLASP NQGVWDMRGK QFFTGVEIRI 540
  541 WAIACFAPQR TVREDALRNF TQQLQKISND AGMPIIGQPC FCKYATGPDQ VEPMFRYLKI 600
  601 TFPGLQLVVV VLPGKTPVYA EVKRVGDTVL GMATQCVQAK NVNKTSPQTL SNLCLKINVK 660
  661 LGGINSILVP SIRPKVFNEP VIFLGADVTH PPAGDNKKPS IAAVVGSMDA HPSRYAATVR 720
  721 VQQHRQEIIQ ELSSMVRELL IMFYKSTGGY KPHRIILYRD GVSEGQFPHV LQHELTAIRE 780
  781 ACIKLEPEYR PGITFIVVQK RHHTRLFCAE KKEQSGKSGN IPAGTTVDVG ITHPTEFDFY 840
  841 LCSHQGIQGT SRPSHYHVLW DDNHFDSDEL QCLTYQLCHT YVRCTRSVSI PAPAYYAHLV 900
  901 AFRARYHLVE KEHDSGEGSH QSGCSEDRTP GAMARAITVH ADTKKVMYFA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..94] MSA 57.160997 View MSA. No confident structure predictions are available.
    2 View Details [95..301] FFAS03 2.83 Crystal structure of full length Argonaute from Pyrococcus furiosus
    3 View Details [302..500] PSI-BLAST 50.30103 Solution Structure of the Drosophila Argonaute 1 PAZ Domain
    4 View Details [501..950] PSI-BLAST 10.69897 The Structure of a Piwi protein from Archaeoglobus fulgidus.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • miRNA binding
    		•  8.69268950569308 bayes_pls_golite062009
  • RNA cap binding
    		•  6.0791415062122 bayes_pls_golite062009
  • translation initiation factor activity
    		•  5.50078893654345 bayes_pls_golite062009
  • RNA 7-methylguanosine cap binding
    		•  5.43471478554516 bayes_pls_golite062009
  • siRNA binding
    		•  4.26412929341885 bayes_pls_golite062009
  • RNA binding
    		•  4.23761892485628 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.70139792513064 bayes_pls_golite062009
  • binding
    		•  2.52855691585079 bayes_pls_golite062009
  • protein binding
    		•  2.40440976820485 bayes_pls_golite062009
  • ribonuclease activity
    		•  1.7851440901313 bayes_pls_golite062009
  • translation regulator activity
    		•  1.24691427875148 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  1.22763794139559 bayes_pls_golite062009
  • hydrolase activity
    		•  0.761541237875448 bayes_pls_golite062009
  • catalytic activity
    		•  0.276917867171685 bayes_pls_golite062009
    4
    Term Confidence Notes
  • ribonuclease activity
    		•  5.30591758406946 bayes_pls_golite062009
  • ribonuclease III activity
    		•  4.20335726467076 bayes_pls_golite062009
    		• 4.10363762148891 bayes_pls_golite062009
  • exoribonuclease activity
    		•  3.71639182685131 bayes_pls_golite062009
  • exoribonuclease activity, producing 5'-phosphomonoesters
    		•  3.59362615133405 bayes_pls_golite062009
  • exonuclease activity
    		•  3.13676176369406 bayes_pls_golite062009
  • nuclease activity
    		•  3.11657409772275 bayes_pls_golite062009
  • RNA binding
    		•  3.01997241125209 bayes_pls_golite062009
  • transposase activity
    		•  2.97988408226992 bayes_pls_golite062009
  • ribonuclease H activity
    		•  2.91966688044755 bayes_pls_golite062009
  • hydrolase activity
    		•  2.78602644579272 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  2.70794511869438 bayes_pls_golite062009
  • endonuclease activity
    		•  2.63074055051349 bayes_pls_golite062009
  • endoribonuclease activity
    		•  2.59247838057313 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.20855917457806 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.14285769817394 bayes_pls_golite062009
  • 3'-5'-exoribonuclease activity
    		•  2.12039058720352 bayes_pls_golite062009
  • exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  1.94077739152313 bayes_pls_golite062009
  • deoxyribonuclease activity
    		•  1.87431870698721 bayes_pls_golite062009
  • DNA binding
    		•  1.86594005896134 bayes_pls_golite062009
  • endoribonuclease activity, producing 5'-phosphomonoesters
    		•  1.74431545836806 bayes_pls_golite062009
  • DNA polymerase activity
    		•  1.64519652804477 bayes_pls_golite062009
  • endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  1.59628511603826 bayes_pls_golite062009
  • DNA-directed DNA polymerase activity
    		•  1.54576601235316 bayes_pls_golite062009
  • 3'-5' exonuclease activity
    		•  1.44123900197846 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.363399194272 bayes_pls_golite062009
  • binding
    		•  1.35497934205068 bayes_pls_golite062009
  • catalytic activity
    		•  1.25233849524628 bayes_pls_golite062009
  • transcription activator activity
    		•  1.1830013572628 bayes_pls_golite062009
  • transcription factor activity
    		•  1.17659544650821 bayes_pls_golite062009
  • mRNA binding
    		•  1.10473275263716 bayes_pls_golite062009
  • protein binding
    		•  1.08578027658199 bayes_pls_golite062009
  • exodeoxyribonuclease activity, producing 5'-phosphomonoesters
    		•  0.782108781904855 bayes_pls_golite062009
  • exodeoxyribonuclease activity
    		•  0.77421125364834 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.599626528449085 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.58055486321736 bayes_pls_golite062009
  • kinase activity
    		•  0.557302038379807 bayes_pls_golite062009
  • endodeoxyribonuclease activity
    		•  0.48776342704945 bayes_pls_golite062009
  • protein kinase activity
    		•  0.354993329967566 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.283883977748512 bayes_pls_golite062009
  • double-stranded RNA-specific ribonuclease activity
    		•  0.222737597484808 bayes_pls_golite062009
  • transferase activity
    		•  0.0868471791986259 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.0701825322473915 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.93

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle