| Protein: | AGO1-PB |
| Organism: | Drosophila melanogaster |
| Length: | 950 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for AGO1-PB.
| Description | E-value | Query Range |
Subject Range |
|
|
1108.0 | [0..7] | [950..41] |
|
Region A: Residues: [1-94] |
1 11 21 31 41 51
| | | | | |
1 MYPVGQQSQW TPSPTRPQSP SQAQTSFDTL TSPPAPGSSV NPTAVTSPSA QNVAAGGATV 60
61 AGAAATAAQV ASALGATTGS VTPAIATATP ATQP
|
| Detection Method: |  |
Shown below is our most confident prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [95-301] |
1 11 21 31 41 51
| | | | | |
1 DMPVFTCPRR PNLGREGRPI VLRANHFQVT MPRGYVHHYD INIQPDKCPR KVNREIIETM 60
61 VHAYSKIFGV LKPVFDGRNN LYTRDPLPIG NERLELEVTL PGEGKDRIFR VTIKWQAQVS 120
121 LFNLEEALEG RTRQIPYDAI LALDVVMRHL PSMTYTPVGR SFFSSPEGYY HPLGGGREVW 180
181 FGFHQSVRPS QWKMMLNIDV SATAFYK
|
| Detection Method: | |
| Confidence: | 2.83 |
| Match: | 1u04A |
| Description: | Crystal structure of full length Argonaute from Pyrococcus furiosus |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [302-500] |
1 11 21 31 41 51
| | | | | |
1 AQPVIDFMCE VLDIRDINEQ RKPLTDSQRV KFTKEIKGLK IEITHCGQMR RKYRVCNVTR 60
61 RPAQMQSFPL QLENGQTVEC TVAKYFLDKY RMKLRYPHLP CLQVGQEHKH TYLPLEVCNI 120
121 VAGQRCIKKL TDMQTSTMIK ATARSAPDRE REINNLVKRA DFNNDSYVQE FGLTISNSMM 180
181 EVRGRVLPPP KLQYGGRVS
|
| Detection Method: | |
| Confidence: | 50.30103 |
| Match: | 1r4kA |
| Description: | Solution Structure of the Drosophila Argonaute 1 PAZ Domain |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| miRNA binding | 8.69268950569308 | bayes_pls_golite062009 |
| RNA cap binding | 6.0791415062122 | bayes_pls_golite062009 |
| translation initiation factor activity | 5.50078893654345 | bayes_pls_golite062009 |
| RNA 7-methylguanosine cap binding | 5.43471478554516 | bayes_pls_golite062009 |
| siRNA binding | 4.26412929341885 | bayes_pls_golite062009 |
| RNA binding | 4.23761892485628 | bayes_pls_golite062009 |
| nucleic acid binding | 2.70139792513064 | bayes_pls_golite062009 |
| binding | 2.52855691585079 | bayes_pls_golite062009 |
| protein binding | 2.40440976820485 | bayes_pls_golite062009 |
| ribonuclease activity | 1.7851440901313 | bayes_pls_golite062009 |
| translation regulator activity | 1.24691427875148 | bayes_pls_golite062009 |
| translation factor activity, nucleic acid binding | 1.22763794139559 | bayes_pls_golite062009 |
| hydrolase activity | 0.761541237875448 | bayes_pls_golite062009 |
| catalytic activity | 0.276917867171685 | bayes_pls_golite062009 |
|
Region A: Residues: [501-950] |
1 11 21 31 41 51
| | | | | |
1 TGLTGQQLFP PQNKVSLASP NQGVWDMRGK QFFTGVEIRI WAIACFAPQR TVREDALRNF 60
61 TQQLQKISND AGMPIIGQPC FCKYATGPDQ VEPMFRYLKI TFPGLQLVVV VLPGKTPVYA 120
121 EVKRVGDTVL GMATQCVQAK NVNKTSPQTL SNLCLKINVK LGGINSILVP SIRPKVFNEP 180
181 VIFLGADVTH PPAGDNKKPS IAAVVGSMDA HPSRYAATVR VQQHRQEIIQ ELSSMVRELL 240
241 IMFYKSTGGY KPHRIILYRD GVSEGQFPHV LQHELTAIRE ACIKLEPEYR PGITFIVVQK 300
301 RHHTRLFCAE KKEQSGKSGN IPAGTTVDVG ITHPTEFDFY LCSHQGIQGT SRPSHYHVLW 360
361 DDNHFDSDEL QCLTYQLCHT YVRCTRSVSI PAPAYYAHLV AFRARYHLVE KEHDSGEGSH 420
421 QSGCSEDRTP GAMARAITVH ADTKKVMYFA
|
| Detection Method: | |
| Confidence: | 10.69897 |
| Match: | 1w9hA |
| Description: | The Structure of a Piwi protein from Archaeoglobus fulgidus. |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| ribonuclease activity | 5.30591758406946 | bayes_pls_golite062009 |
| ribonuclease III activity | 4.20335726467076 | bayes_pls_golite062009 |
| 4.10363762148891 | bayes_pls_golite062009 | |
| exoribonuclease activity | 3.71639182685131 | bayes_pls_golite062009 |
| exoribonuclease activity, producing 5'-phosphomonoesters | 3.59362615133405 | bayes_pls_golite062009 |
| exonuclease activity | 3.13676176369406 | bayes_pls_golite062009 |
| nuclease activity | 3.11657409772275 | bayes_pls_golite062009 |
| RNA binding | 3.01997241125209 | bayes_pls_golite062009 |
| transposase activity | 2.97988408226992 | bayes_pls_golite062009 |
| ribonuclease H activity | 2.91966688044755 | bayes_pls_golite062009 |
| hydrolase activity | 2.78602644579272 | bayes_pls_golite062009 |
| hydrolase activity, acting on ester bonds | 2.70794511869438 | bayes_pls_golite062009 |
| endonuclease activity | 2.63074055051349 | bayes_pls_golite062009 |
| endoribonuclease activity | 2.59247838057313 | bayes_pls_golite062009 |
| transcription regulator activity | 2.20855917457806 | bayes_pls_golite062009 |
| nucleic acid binding | 2.14285769817394 | bayes_pls_golite062009 |
| 3'-5'-exoribonuclease activity | 2.12039058720352 | bayes_pls_golite062009 |
| exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters | 1.94077739152313 | bayes_pls_golite062009 |
| deoxyribonuclease activity | 1.87431870698721 | bayes_pls_golite062009 |
| DNA binding | 1.86594005896134 | bayes_pls_golite062009 |
| endoribonuclease activity, producing 5'-phosphomonoesters | 1.74431545836806 | bayes_pls_golite062009 |
| DNA polymerase activity | 1.64519652804477 | bayes_pls_golite062009 |
| endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters | 1.59628511603826 | bayes_pls_golite062009 |
| DNA-directed DNA polymerase activity | 1.54576601235316 | bayes_pls_golite062009 |
| 3'-5' exonuclease activity | 1.44123900197846 | bayes_pls_golite062009 |
| general RNA polymerase II transcription factor activity | 1.363399194272 | bayes_pls_golite062009 |
| binding | 1.35497934205068 | bayes_pls_golite062009 |
| catalytic activity | 1.25233849524628 | bayes_pls_golite062009 |
| transcription activator activity | 1.1830013572628 | bayes_pls_golite062009 |
| transcription factor activity | 1.17659544650821 | bayes_pls_golite062009 |
| mRNA binding | 1.10473275263716 | bayes_pls_golite062009 |
| protein binding | 1.08578027658199 | bayes_pls_golite062009 |
| exodeoxyribonuclease activity, producing 5'-phosphomonoesters | 0.782108781904855 | bayes_pls_golite062009 |
| exodeoxyribonuclease activity | 0.77421125364834 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 0.599626528449085 | bayes_pls_golite062009 |
| phosphotransferase activity, alcohol group as acceptor | 0.58055486321736 | bayes_pls_golite062009 |
| kinase activity | 0.557302038379807 | bayes_pls_golite062009 |
| endodeoxyribonuclease activity | 0.48776342704945 | bayes_pls_golite062009 |
| protein kinase activity | 0.354993329967566 | bayes_pls_golite062009 |
| DNA helicase activity | 0.283883977748512 | bayes_pls_golite062009 |
| double-stranded RNA-specific ribonuclease activity | 0.222737597484808 | bayes_pls_golite062009 |
| transferase activity | 0.0868471791986259 | bayes_pls_golite062009 |
| structure-specific DNA binding | 0.0701825322473915 | bayes_pls_golite062009 |
