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Protein Overview: Nrk-PA

General Information:
Name(s) found: Nrk-PA / FBpp0086841 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • The gene Neurospecific receptor kinase is referred to in FlyBase by the symbol Dmel\Nrk (CG4007, FBgn0020391). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:9047554..9050989. It has the cytological map location 49F4. There is experimental evidence that it has the molecular function</span>: protein tyrosine kinase activity. There is experimental evidence that it is involved in the biological process</span>: protein amino acid phosphorylation; signal transduction. 6 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 724 amino acids

    Gene Ontology:
    Cellular Component: plasma membrane [ISS]
    Biological Process: signal transduction [IDA]
    transmembrane receptor protein tyrosine kinase signaling pathway [IEA]
    protein amino acid phosphorylation [IDA][NAS]
    Molecular Function: ATP binding [IEA]
    protein tyrosine kinase activity [IDA][NAS]
    protein binding [IEA]
    transmembrane receptor protein tyrosine kinase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAGQWVGVV ERVLRGMVLK WGANLAVLGL CVFLFASATH ANSLNAIEEP VTRRHHQRHH  60
   61 EREREENGYC APYSGKVCKE YLTGQVWYSL EDPTGGWKNE QVTTALWDEL ISDLTGLCRE 120
  121 AAEKMLCAYA FPNCHMEGGR AVKAPLCFED CQATHLQFCY NDWVLIEEKK ERNMFIKSRG 180
  181 HFRLPNCSSL PHYNASMRRP NCSYIGLTEL KESEVSYDCR NGNGRFYMGT MNVSKSGIPC 240
  241 QRWDTQYPHK HFQPPLVFHQ LLEGENYCRN AGGEEPHPWC YTVDESVRWQ HCDIPMCPDY 300
  301 VDPNAVDLNT PIKMEKFFTP SMIFLLAGIG FVAIVTLHLM ILLVYKLSKH KDYSQPAGAA 360
  361 TAECSVSMRG GGDCGGNLNT SRETLGGNGN TNTLAKWGTI RSTATIHSNC VALTTVTNVS 420
  421 DAKGTKPNAR LEKLEYPRGD IVYVRSLGQG AFGRVFQARA PGLVPDQEDL LVAVKMLKDD 480
  481 ASDQMQMDFE REACLLAEFD HPNIVRLLGV CALGRPMCLL FEYMAPGDLS EFLRACSPYA 540
  541 THQAPTQDRL QLNELHLLQM AANIAAGMLY LSERKFVHRD LATRNCLINE HMAVKIADFG 600
  601 LSHKIYLQDY YKGDENDFIP IRWMPLESIL YNKFSLESDV WAYGICLWEV FSFALQPYFG 660
  661 LTHEEVIKYI KEGNVLGCPD NTPLSVYALM RRCWNRKPSE RPGFAEINHC IQHSIAESEC 720
  721 KAML

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..139] FFAS03 1.95 Frizzled 8 (FZ8)
    2 View Details [140..285] PSI-BLAST 25.39794 Plasminogen
    3 View Details [286..386] PSI-BLAST 4.154902 SH3-SH2 DOMAIN FRAGMENT OF HUMAN BCR-ABL TYROSINE KINASE
    4 View Details [387..724] PSI-BLAST 72.39794 Musk tyrosine kinase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transmembrane receptor activity
    		•  4.12744895314187 bayes_pls_golite062009
  • receptor activity
    		•  3.87682364042772 bayes_pls_golite062009
  • signal transducer activity
    		•  3.01939524477326 bayes_pls_golite062009
  • molecular transducer activity
    		•  3.01939524477326 bayes_pls_golite062009
  • Wnt receptor activity
    		•  2.31013454239678 bayes_pls_golite062009
  • binding
    		•  2.1646903962543 bayes_pls_golite062009
  • protein binding
    		•  2.08965369645498 bayes_pls_golite062009
  • Wnt-protein binding
    		•  1.42144939971845 bayes_pls_golite062009
    2
    Term Confidence Notes
  • receptor activity
    		•  2.74055213309696 bayes_pls_golite062009
  • signal transducer activity
    		•  2.11223109564776 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.11223109564776 bayes_pls_golite062009
  • binding
    		•  1.90408871052739 bayes_pls_golite062009
  • protein binding
    		•  1.52504676895038 bayes_pls_golite062009
  • hydrolase activity
    		•  0.946525235212821 bayes_pls_golite062009
  • catalytic activity
    		•  0.280235123429996 bayes_pls_golite062009
    3
    Term Confidence Notes
  • protein binding
    		•  3.13677730481089 bayes_pls_golite062009
  • binding
    		•  3.06905798270146 bayes_pls_golite062009
  • actin filament binding
    		•  2.59742039155224 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.21254869336424 bayes_pls_golite062009
  • signal transducer activity
    		•  1.80011194349017 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.80011194349017 bayes_pls_golite062009
  • actin binding
    		•  1.79651396322487 bayes_pls_golite062009
  • vinculin binding
    		•  1.63216315345235 bayes_pls_golite062009
  • receptor binding
    		•  1.14419687627233 bayes_pls_golite062009
  • transporter activity
    		•  0.896907103596953 bayes_pls_golite062009
  • epidermal growth factor receptor binding
    		•  0.80673395326897 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.713068405985864 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.500685400112742 bayes_pls_golite062009
  • insulin receptor binding
    		•  0.275913005279959 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.272368655500689 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.00318812576030902 bayes_pls_golite062009
    4
    Term Confidence Notes
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.04467222534257 bayes_pls_golite062009
  • kinase activity
    		•  4.85903980916957 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.63692708178478 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • fibroblast growth factor 1 binding
    		•  4.09909681656699 bayes_pls_golite062009
  • stem cell factor receptor activity
    		•  3.82614202737632 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  3.41480681854114 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  3.40140621607334 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  3.1965684217331 bayes_pls_golite062009
  • receptor activity
    		•  2.96273889901429 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.85730457922199 bayes_pls_golite062009
  • signal transducer activity
    		•  2.85730457922199 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  2.8153155526437 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • fibroblast growth factor receptor activity
    		•  2.70917101514973 bayes_pls_golite062009
  • growth factor binding
    		•  2.61235080252818 bayes_pls_golite062009
  • transferase activity
    		•  2.34875558765742 bayes_pls_golite062009
  • protein binding
    		•  2.276111749106 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  2.10379226653669 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • fibroblast growth factor binding
    		•  1.9011085456623 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  1.82515074380651 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.81249386965144 bayes_pls_golite062009
  • non-membrane spanning protein tyrosine kinase activity
    		•  1.66669268613198 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • transforming growth factor beta receptor activity
    		•  1.51779793980227 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase activity
    		•  1.51779793980227 bayes_pls_golite062009
  • kinase binding
    		•  1.26086833316556 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.10597058961079 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.06086848160606 bayes_pls_golite062009
  • protein kinase binding
    		•  1.06030596516506 bayes_pls_golite062009
  • receptor binding
    		•  0.990272341309676 bayes_pls_golite062009
  • insulin receptor substrate binding
    		•  0.95914323793919 bayes_pls_golite062009
  • DNA binding
    		•  0.956433441855102 bayes_pls_golite062009
  • transcription activator activity
    		•  0.955593006663586 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  0.867779574651545 bayes_pls_golite062009
  • insulin-like growth factor binding
    		•  0.82854091092242 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.81943579965027 bayes_pls_golite062009
  • transcription factor activity
    		•  0.790106588313006 bayes_pls_golite062009
  • platelet-derived growth factor receptor binding
    		•  0.770658204347392 bayes_pls_golite062009
  • transporter activity
    		•  0.710766490066447 bayes_pls_golite062009
  • growth factor activity
    		•  0.707777793848936 bayes_pls_golite062009
  • actin filament binding
    		•  0.66248865719696 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  0.610230065465794 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.60324822483033 bayes_pls_golite062009
  • JUN kinase kinase kinase kinase activity
    		•  0.546647574638943 bayes_pls_golite062009
  • cytokine receptor binding
    		•  0.516151105278102 bayes_pls_golite062009
  • activin binding
    		•  0.510364757301021 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.499492353295369 bayes_pls_golite062009
  • enzyme binding
    		•  0.46284745266176 bayes_pls_golite062009
  • protein kinase C activity
    		•  0.41587987561486 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.385603245903806 bayes_pls_golite062009
  • insulin receptor activity
    		•  0.359260732334699 bayes_pls_golite062009
  • polysaccharide binding
    		•  0.344522125452779 bayes_pls_golite062009
  • heparin binding
    		•  0.334438853447262 bayes_pls_golite062009
  • transforming growth factor beta binding
    		•  0.287757704969289 bayes_pls_golite062009
  • protein complex binding
    		•  0.239339759110451 bayes_pls_golite062009
  • transforming growth factor beta receptor activity, type I
    		•  0.233896787419349 bayes_pls_golite062009
  • cytokine binding
    		•  0.17817111033393 bayes_pls_golite062009
  • activin receptor activity
    		•  0.163693280420599 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.152203945257581 bayes_pls_golite062009
  • hydrolase activity
    		•  0.0498504410225162 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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