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Protein Overview: FBpp0303361

General Information:
Name(s) found: FBpp0303361 [FlyBase]
Description(s) found:
Found 23 descriptions.
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  • type=protein; loc=2R:complement(9030631..9030822,9030880..9032193,9036176..9036395,9036458..9037188,9037255..9038337,9038394..9038793,9038872..9038941,9040124..9040127); ID=FBpp0303361; name=Ack-like-PA; parent=FBgn0263998,FBtr0330329; dbxref=FlyBase_Annotation_IDs:CG43741-PA,FlyBase:FBpp0303361,REFSEQ:NP_477086,GB_protein:AAG22275; MD5=d25b335598346f60b2a556e874e8f042; length=1337; release=r5.56; species=Dmel; [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1337 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: autophagic cell death [IEP]
    salivary gland cell autophagic cell death [IEP]
    protein amino acid phosphorylation [IEA][ISS][NAS]
    Molecular Function: ATP binding [IEA]
    protein tyrosine kinase activity [ISS][NAS]
    protein binding [IEA]
    non-membrane spanning protein tyrosine kinase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEYPQIDLYE FLTESELQQY YNAVKNELKI TNAAQFKYAA DEDLRFIGLS RPEIRRLRKF  60
   61 YEKHFPHSYL SKIKRLLQAP GTMVKREEAP GGGSQVALDG SSASACSSLA AKNGASSPSK 120
  121 VPNNKHIIPA DSISVNKQLG TGEFGIVQQG VWSNGNERIQ VAIKCLCRER MQSNPMEFLK 180
  181 EAAIMHSIEH ENIVRLYGVV LATDSLMLVT ELAHLRSLLE CLKDSGLRVS FLTIPTLCEF 240
  241 ALQICNGMRY LEQKRLIHRD LAARNILVFS KDKVKISDFG LSRALGVGKD YYKTNFNVNL 300
  301 KLPIAWCAPE CINYLRFTNA SDVWAFGVCL WEMFSYGFQP WAALTGLQIL EAIDAPNYQR 360
  361 LEQPDCCPSE YYTLMMKCWQ DDAAKRPRFG EIYDQLPDMK PEQLKAVVNC TEPKKDHLLY 420
  421 RQGDIISVLD RNTGTPFWKG VLSTGKTGYF NPSNTVAFLE GLPSSTRDSF SRVSDHRISK 480
  481 RKLRTEMISK PQNDFKHTGH VGIDGATFGD IAFLGSSQNY NHVPKQIVTP YKPSEDIEQT 540
  541 PLLLPPTPTS PDSLQTASGY FPEGANSGGA MGTSMNPTFI PSAEHTPKLI ATNGQSSFDF 600
  601 ASGSTNPFFP NRGDDELEFG LHNYGADGKS VHSETGWRPT SRSIVDDPHE YHEISDDEIA 660
  661 ADKLDFGPSL LDEINSMFGS ISAATGSHPK SPGFDHVNNK NEITEMSAKL GQKSGDTNGN 720
  721 KHGHGLLPTL SKKKSSGTVK PISVKDEKIL NHAIEIANEI SARSMIDLVS DQTPVIHSPK 780
  781 RKFSFRFPHL SNNGSGDKSG GLGTSGSAHT PTHGNASPFP KKKNFTEELQ SIPDIQSLIG 840
  841 KEGLEAYNSL IERKALLDIG PSPAATLLRH LDTDEFDLQS LHQSQRPMTL PTRGATQRVR 900
  901 KAELAAGLSR HNDENSNSLE ACESPSYMTH GSYKFPEAQP TEQLPEPESP NPIPLPPREG 960
  961 KKQVKTSTKR HVRKYPLIIP ANGLQRTLSK LADFGDEAAK SPEISTSSQP QPGRAIEVVA1020
 1021 AVRPSGMRRP SRPSEREYEN MPTVGKESAH TYQNLDKLTP ADAAGLTDTA SLQFESIMEA1080
 1081 DTSKEGILQS PDVTDGFYNF SIQKEHYNKG KDAEFEATQI SGLYVNDDEL RNLDIESSRR1140
 1141 TATPCSSCSA LESEHSQPDA LPSTESVSEV SRFSSVDNEL AGNALFKKVR ASVNMAMNRK1200
 1201 SVAETSLTSN QPGGASAKPQ TEAEYFAATA ARLADSNSVS CEDLLEFSDK KPKGCERGVD1260
 1261 SDEVRIMVKV LGKDSTPNRC LGALEFINWD VHKSIKLIKL QNLVSEANLS LEASFEALQQ1320
 1321 HEWDLHTTAH KLNGLKL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..409] PSI-BLAST 98.30103 Abl tyrosine kinase, SH3 domain; Abl tyrosine kinase; Abelsone tyrosine kinase (abl)
    2 View Details [410..466] PSI-BLAST 68.69897 No description for 2gnfA was found.
    3 View Details [467..589] deduced N/A No confident structure predictions are available.
    4 View Details [590..774] deduced N/A No confident structure predictions are available.
    5 View Details [775..943] deduced N/A No confident structure predictions are available.
    6 View Details [944..1337] FFAS03 3.33 No description for 2ch7B was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein kinase activity
    		•  5.63683237027974 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.24105099841813 bayes_pls_golite062009
  • kinase activity
    		•  5.02394449930162 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.38615595541751 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.33927583810751 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  3.41480681854114 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  3.40140621607334 bayes_pls_golite062009
  • transferase activity
    		•  3.26787750561728 bayes_pls_golite062009
  • epidermal growth factor receptor binding
    		•  2.9751846707539 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  2.8153155526437 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  2.59526003830791 bayes_pls_golite062009
  • signal transducer activity
    		•  2.40586892801446 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.40586892801446 bayes_pls_golite062009
  • receptor activity
    		•  2.39311927684508 bayes_pls_golite062009
  • protein binding
    		•  2.276111749106 bayes_pls_golite062009
  • binding
    		•  2.10874590528357 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  2.10379226653669 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.81249386965144 bayes_pls_golite062009
  • molecular adaptor activity
    		•  1.81145713371725 bayes_pls_golite062009
  • non-membrane spanning protein tyrosine kinase activity
    		•  1.66669268613198 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • vinculin binding
    		•  1.63216315345235 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • SH3/SH2 adaptor activity
    		•  1.59474164216385 bayes_pls_golite062009
  • growth factor binding
    		•  1.53863828216563 bayes_pls_golite062009
  • integrin binding
    		•  1.44154155381408 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • transforming growth factor beta receptor activity
    		•  1.10045286406485 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase activity
    		•  1.10045286406485 bayes_pls_golite062009
  • insulin receptor substrate binding
    		•  0.95914323793919 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  0.91037901281763 bayes_pls_golite062009
  • protein binding, bridging
    		•  0.777367738889091 bayes_pls_golite062009
  • fibroblast growth factor receptor activity
    		•  0.75189004129952 bayes_pls_golite062009
  • transporter activity
    		•  0.710766490066447 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.60324822483033 bayes_pls_golite062009
  • activin binding
    		•  0.510364757301021 bayes_pls_golite062009
  • protein kinase C activity
    		•  0.41587987561486 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.385603245903806 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  0.371991354471077 bayes_pls_golite062009
  • protein phosphorylated amino acid binding
    		•  0.366165352815341 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.310771535422373 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.30489652511141 bayes_pls_golite062009
  • kinase binding
    		•  0.26752427107238 bayes_pls_golite062009
  • protein complex binding
    		•  0.239339759110451 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.152203945257581 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.0675236791909441 bayes_pls_golite062009
  • transforming growth factor beta receptor activity, type I
    		•  0.0506751594607393 bayes_pls_golite062009
  • JUN kinase kinase kinase kinase activity
    		•  0.0393215018817107 bayes_pls_golite062009
  • protein kinase binding
    		•  0.00674998152095019 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle