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Protein Overview: CG12374-PA

General Information:
Name(s) found: CG12374-PA / FBpp0086967 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • This gene is referred to in FlyBase by the symbol Dmel\CG12374 (CG12374, FBgn0033774). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:8649617..8651330. It has the cytological map location 49C3. Based on sequence similarity, it is predicted to have molecular function</span>: metallocarboxypeptidase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: proteolysis. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 422 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: proteolysis [IEA]
    Molecular Function: zinc ion binding [IEA]
    metallocarboxypeptidase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKLPILLITL VAMVAAKSAP GRMAARYDHF RIYQLTIETN LQMEELKKIH EHISVHFLNE  60
   61 LGAVGNKYNV IVGPLFHRAL EKTLKFLEIV YEVIVDDLQK LIDESSVGDD SQMEWETYHT 120
  121 LDTIYDWIDQ ECAAHDFLEC KVIGQSYEGR DIKSIRLSKR SGNKAIFLEG NIHAMEWISS 180
  181 ATVTFLLNQL INSEDPEMQR LSEEYDWIVV PMVNPDGFVY THEVERLWRK NRRPNGYRNE 240
  241 SGDCYGIDMN RNFDYHWGGA GWNIDEPCDH WFGGEEPNTE VEIISLQNFV SSFEDGYIRS 300
  301 YMAYHAYGQY VLLPYGHSNT EFPPNYEQMK RIAAAFSDAA ADVYGSTFTY GASGLLNYVV 360
  361 SGAAKDWAYG VKKIPFTCTV ELRDKGTFGF FLPSNQITEV GLEVTAGLKA LVNKAAEEGI 420
  421 FD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..422] PSI-BLAST 101.0 HUMAN PROCARBOXYPEPTIDASE A2

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • peptidase activity
    		•  4.786910294594 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  4.40766568731738 bayes_pls_golite062009
  • hydrolase activity
    		•  4.23257784904124 bayes_pls_golite062009
  • exopeptidase activity
    		•  3.28577934113028 bayes_pls_golite062009
  • metallopeptidase activity
    		•  2.76103081380105 bayes_pls_golite062009
  • carboxypeptidase activity
    		•  2.63658263814587 bayes_pls_golite062009
  • metalloexopeptidase activity
    		•  1.76058821499096 bayes_pls_golite062009
  • metallocarboxypeptidase activity
    		•  1.56827526553175 bayes_pls_golite062009
  • catalytic activity
    		•  1.3989281287879 bayes_pls_golite062009
  • binding
    		•  1.18091528890016 bayes_pls_golite062009
  • endopeptidase activity
    		•  0.910234727191613 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
    		•  0.723243947871592 bayes_pls_golite062009
  • serine hydrolase activity
    		•  0.596149133958797 bayes_pls_golite062009
  • serine-type peptidase activity
    		•  0.578572340123331 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.454707207494165 bayes_pls_golite062009
  • protein binding
    		•  0.215930537243465 bayes_pls_golite062009
  • DNA binding
    		•  0.115087846898245 bayes_pls_golite062009
  • aminopeptidase activity
    		•  0.0966237570696103 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.0479880797560268 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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