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Protein Overview: tor-PA

General Information:
Name(s) found: tor-PA / FBpp0088012 [FlyBase]
Description(s) found:
Found 27 descriptions.
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  • The gene torso is referred to in FlyBase by the symbol Dmel\tor (CG1389, FBgn0003733). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:3590680..3597042. It has the cytological map location 43E11-43E12. Based on sequence similarity, it is predicted to have molecular function</span>: transmembrane receptor protein tyrosine kinase activity. There is experimental evidence that it is involved in the biological process</span>: terminal region determination; pole cell migration; gastrulation; chorion-containing eggshell pattern formation. 132 alleles are reported. The phenotypes of these alleles are annotated with 39 unique terms, many of which group under: organ system; peripheral nervous system; nervous system; gastrula embryo; portion of tissue; embryonic segment; abdominal segment 7; mouthpart; primordium; cephalopharyngeal skeleton. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 923 amino acids

    Gene Ontology:
    Cellular Component: plasma membrane [NAS]
    Biological Process: torso signaling pathway [NAS][TAS]
    pole cell migration [IMP]
    terminal region determination [IMP][NAS]
    chorion-containing eggshell pattern formation [IMP]
    anterior/posterior axis specification, embryo [TAS]
    Malpighian tubule morphogenesis [TAS]
    protein amino acid phosphorylation [IEA][NAS]
    cell fate determination [TAS]
    gastrulation [IMP]
    Molecular Function: ATP binding [IEA]
    protein tyrosine kinase activity [IEA][NAS]
    protein binding [IEA]
    transmembrane receptor protein tyrosine kinase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLIFYAKYAF IFWFFVGSNQ GEMLLMDKIS HDKTLLNVTA CTQNCLEKGQ MDFRSCLKDC  60
   61 RINGTFPGAL RKVQENYQMN MICRTESEIV FQIDWVQHSR GTEPAPNATY IIRVDAVKDD 120
  121 NKETALYLSD DNFLILPGLE SNSTHNITAL AMHGDGSYSL IAKDQTFATL IRGYQPSKMG 180
  181 AVNLLRFVPQ PDDLHHIAAE IEWKPSAESN CYFDMVSYST NSVNMDEPLE VQFRDRKKLY 240
  241 RHTVDNLEFD KQYHVGVRTV NIMNRLESDL QWLPIAVPSC LDWYPYNYTL CPPHKPENLT 300
  301 VTQKQYLPNI LALNITWARP RYLPDNYTLH IFDLFKGGTE LNYTLDQNRS HFYVPKITVL 360
  361 GSHFEVHLVA QSAGGKNVSG LTLDKVHRGV LLSEGNMVKL VLFIIVPICC ILMLCSLTFC 420
  421 RRNRSEVQAL QMDAKDAKAS EFHLSLMDSS GLLVTLSANE SLEVMDELEV EPHSVLLQDV 480
  481 LGEGAFGLVR RGVYKKRQVA VKLLKDEPND EDVYAFKCEI QMLKAVGKHP NIVGIVGYST 540
  541 RFSNQMMLLI EYCSLGSLQN FLREEWKFRQ EQNAIGLKKN LEQNVDNRRF NRLPRNSIHD 600
  601 RIEDINNSML STVEEESESD QTHSSRCETY TLTRITNAAD NKGYGLEDIE NIGGSYIPKT 660
  661 AEAPKDRPKR KLKPQPKKDS KQDFKSDNKK RIFENKEYFD CLDSSDTKPR IPLKYADLLD 720
  721 IAQQVAVGME FLAQNKVVHR DLAARNVLIS VDRSIKIADF GLSRDVYHEN VYRKSGGSGK 780
  781 LPIKWLALES LTHQVYTSQS DVWSFGVLLY EITTLGGMPY PSVSPSDLLQ LLRQGHRMKR 840
  841 PEGCTQEMFS LMESCWSSVP SHRPTFSALK HRLGGMILAT NDVPERLKQL QAATESKLKS 900
  901 CDGLNSKVEQ VPCEEELYLE PLN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..63] PSI-BLAST 13.0 No description for 2nziA was found.
    2 View Details [64..455] PSI-BLAST 22.09691 No description for 2dtgE was found.
    3 View Details [456..664] FFAS03 6.7 No description for 2nruA was found.
    4 View Details [665..923] PSI-BLAST 53.0 No description for 2pvfA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • PTB domain binding
    		•  7.59954514905135 bayes_pls_golite062009
  • insulin receptor activity
    		•  5.32497038633998 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  4.81256300373074 bayes_pls_golite062009
  • interleukin-6 binding
    		•  4.7755079145617 bayes_pls_golite062009
  • interleukin-6 receptor activity
    		•  4.7755079145617 bayes_pls_golite062009
  • receptor activity
    		•  4.66147271961356 bayes_pls_golite062009
  • molecular transducer activity
    		•  3.69234048247377 bayes_pls_golite062009
  • signal transducer activity
    		•  3.69234048247377 bayes_pls_golite062009
  • ciliary neurotrophic factor receptor activity
    		•  3.63622123190665 bayes_pls_golite062009
  • protein binding
    		•  3.24522318184038 bayes_pls_golite062009
  • oncostatin-M receptor activity
    		•  3.21526092940028 bayes_pls_golite062009
  • leukemia inhibitory factor receptor activity
    		•  3.21526092940028 bayes_pls_golite062009
  • cytokine binding
    		•  3.21238178184503 bayes_pls_golite062009
  • binding
    		•  3.12471204223368 bayes_pls_golite062009
  • SH2 domain binding
    		•  3.02533711127154 bayes_pls_golite062009
  • growth factor binding
    		•  2.99437744892471 bayes_pls_golite062009
  • ciliary neurotrophic factor receptor binding
    		•  2.79717898377819 bayes_pls_golite062009
  • cytokine receptor activity
    		•  2.76876397305497 bayes_pls_golite062009
  • cytokine receptor binding
    		•  2.64284554734326 bayes_pls_golite062009
  • ciliary neurotrophic factor binding
    		•  2.27923575030525 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.25224014924603 bayes_pls_golite062009
  • growth hormone receptor activity
    		•  2.20449493522 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.13821456373219 bayes_pls_golite062009
  • peptide binding
    		•  2.04467673245315 bayes_pls_golite062009
  • DNA binding
    		•  1.95396591505956 bayes_pls_golite062009
  • peptide hormone binding
    		•  1.9205359237864 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  1.91712452737778 bayes_pls_golite062009
  • transcription activator activity
    		•  1.72598380808039 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.61421027298524 bayes_pls_golite062009
  • kinase activity
    		•  1.57994485110649 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.44501485815273 bayes_pls_golite062009
  • protein kinase activity
    		•  1.42856560840953 bayes_pls_golite062009
  • insulin binding
    		•  1.40490582483684 bayes_pls_golite062009
  • receptor binding
    		•  1.31676259534833 bayes_pls_golite062009
  • hormone binding
    		•  1.31120662451488 bayes_pls_golite062009
  • interleukin-11 receptor activity
    		•  1.2674474182257 bayes_pls_golite062009
  • interleukin-11 binding
    		•  1.2674474182257 bayes_pls_golite062009
  • transcription factor activity
    		•  1.20939978283833 bayes_pls_golite062009
  • transferase activity
    		•  1.13635878582843 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.86564366658585 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.703490254739121 bayes_pls_golite062009
  • axon guidance receptor activity
    		•  0.664115701581569 bayes_pls_golite062009
  • kinase binding
    		•  0.65927255037265 bayes_pls_golite062009
  • enzyme binding
    		•  0.60195860585095 bayes_pls_golite062009
  • identical protein binding
    		•  0.564711394496051 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  0.554350228628563 bayes_pls_golite062009
  • mercury ion binding
    		•  0.533389420538679 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.46168925186147 bayes_pls_golite062009
  • transcription factor binding
    		•  0.428445565158989 bayes_pls_golite062009
  • protein kinase binding
    		•  0.405060010394646 bayes_pls_golite062009
  • cytokine activity
    		•  0.30745438910441 bayes_pls_golite062009
  • peptidase activator activity
    		•  0.249363133780499 bayes_pls_golite062009
  • interleukin-2 binding
    		•  0.240383688164201 bayes_pls_golite062009
  • prolactin receptor activity
    		•  0.227864369774704 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.211855991357483 bayes_pls_golite062009
  • structural molecule activity
    		•  0.18965275490219 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.1430595594485 bayes_pls_golite062009
  • protein homodimerization activity
    		•  0.116391819218123 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.116377273702831 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.05634414824449 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.15

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle