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Protein Overview: FBpp0311783, dpa-PA

General Information:
Name(s) found: FBpp0311783 [FlyBase]
dpa-PA / FBpp0088055 [FlyBase]
Description(s) found:
Found 27 descriptions.
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  • type=protein; loc=2R:complement(3384306..3384401,3384462..3384914,3384984..3385350,3385412..3385783,3385844..3386772,3386832..3387142,3387207..3387279); ID=FBpp0311783; name=dpa-PB; parent=FBgn0015929,FBtr0345797; dbxref=FlyBase:FBpp0311783,FlyBase_Annotation_IDs:CG1616-PB; MD5=619e71f93d864e69db14713efa7d8539; length=866; release=r5.56; species=Dmel; [FlyBase]
  • The gene disc proliferation abnormal is referred to in FlyBase by the symbol Dmel\dpa (CG1616, FBgn0015929). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:3384206..3387379. It has the cytological map location 43C6-43C7. There is experimental evidence that it has the molecular function</span>: 3'-5' DNA helicase activity. There is experimental evidence that it is involved in the biological process</span>: mitotic spindle organization; DNA replication. 12 alleles are reported. The phenotypes of these alleles are annotated with: chromosome, centromeric region; central nervous system; mitotic cell cycle; spindle; imaginal disc; mitotic metaphase. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 866 amino acids

    Gene Ontology:
    Cellular Component: nucleus [NAS]
    Biological Process: DNA replication initiation [IEA]
    DNA replication [IEA][IMP][ISS][NAS][TAS]
    mitotic spindle organization [IMP]
    [NOT]DNA endoreduplication [NAS]
    Molecular Function: DNA binding [IEA][NAS]
    ATP binding [IEA]
    3'-5' DNA helicase activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSPARSPSV GGATPKQGAR TPTRGIASQD VETPMRMGPG RAVRPSDNIS LPPTSPGNIS  60
   61 LPATSPARGL GANMSEIDLS SPLNYGTPSS MGSIRTPRSG IRGTPLRARP DIRTDKRIRQ 120
  121 VAIGGGSGLE PIPEKGSETT DPVSESSQAP QLVVWGTNVV VSQCKSKFKS FIMRFIDPSA 180
  181 EQDEISENID VNQPLYLQKL EEIHTLEEPY LNLNCAHLKT FDQDLYRQLI CYPQEVIPGF 240
  241 DMAINEMFFE RYPAALLEHQ IQVRPFNADK TRNMRSLNPE DMDQLISISG MVIRSSNVIP 300
  301 EMREAFFSCN ICSFSTTVEV DRGRINQPTL CTNCNTNHCF RLIHNRSEFT DKQLVKLQES 360
  361 PDDMAAGQTP HNVLLYAHND LVDKVQPGDR VTVTGIYRAT PLKTGGLSSS VKSVYKTHVD 420
  421 VVHFRKVDNK RLYEDEEGKD HIFPPERVEL LQLLAKKPDI YDRLARAIAP SIYENDDIKK 480
  481 GILLQLFGGT KKKHATLGRQ NFRSEIHLLL CGDPGTSKSQ MLQYVFNLVP RSQYTSGRGS 540
  541 SAVGLTAYVT KDPETRQLVL QTGALVLADN GVCCIDEFDK MNDSTRSVLH EVMEQQTLSI 600
  601 AKAGIICQLN ARTSILAAAN PAESQWNKRK NIIDNVQLPH TLLSRFDLIF LVLDPQDEIF 660
  661 DKRLASHLVS LYYVTRHEEE DTMFDMSVLR DYIAYAREHL SPTLSDEAQQ RLIQAYVDMR 720
  721 KVGAGRGQIS AYPRQLESLI RLSEAHAKVR LSNQVELLDV EEAWRLHREA LKQSATDPLS 780
  781 GKIDVGILTT GLSTAARKKR ADLVAAIKEN LKKKGKVLTV PYQKLFSDIK EGSQIMITRE 840
  841 QFEDALKEVQ DEGAIVVMGK NTIRIC

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..162] FFAS03 1.48 No description for 2j63A was found.
    2 View Details [163..276] PSI-BLAST 50.09691 DNA replication initiator (cdc21/cdc54) N-terminal domain
    3 View Details [277..382] FFAS03 5.05 DNA replication initiator (cdc21/cdc54) N-terminal domain
    4 View Details [383..468] PSI-BLAST 39.69897 Crystal structure of sigm54 activator (AAA+ ATPase) in the inactive state
    5 View Details [469..725] PSI-BLAST 8.69897 HslU
    6 View Details [726..866] PSI-BLAST 47.522879 No description for 2r44A was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • DNA clamp loader activity
    		•  4.91429252297969 bayes_pls_golite062009
  • protein-DNA loading ATPase activity
    		•  4.80695929076807 bayes_pls_golite062009
  • motor activity
    		•  2.79327761685782 bayes_pls_golite062009
  • microtubule motor activity
    		•  2.74365461017633 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  2.72462789867829 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  2.66107861968804 bayes_pls_golite062009
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.51683451033161 bayes_pls_golite062009
  • DNA helicase activity
    		•  2.2817164193758 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.13284212711072 bayes_pls_golite062009
  • DNA binding
    		•  2.12258000781149 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.09345198747025 bayes_pls_golite062009
  • telomeric DNA binding
    		•  2.0142766759353 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  1.88455339138556 bayes_pls_golite062009
  • helicase activity
    		•  1.70242731830224 bayes_pls_golite062009
  • DNA replication origin binding
    		•  1.62491387774159 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.53142082854758 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.52938239070386 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.52887308780164 bayes_pls_golite062009
  • nucleotide binding
    		•  1.52746968836881 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  1.47858140861683 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.40488517180956 bayes_pls_golite062009
  • ATP binding
    		•  1.23942044024113 bayes_pls_golite062009
  • protein binding
    		•  1.22129154759482 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.21044170258803 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.20315703345493 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.19481945569892 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  1.19311444180077 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  1.19311444180077 bayes_pls_golite062009
  • kinase activity
    		•  1.11120928120082 bayes_pls_golite062009
  • histone acetyltransferase activity
    		•  1.05990253628867 bayes_pls_golite062009
  • lysine N-acetyltransferase activity
    		•  1.05990253628867 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  1.05408274676326 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • tubulin binding
    		•  0.979946830272106 bayes_pls_golite062009
  • DNA-directed DNA polymerase activity
    		•  0.971476020912368 bayes_pls_golite062009
  • DNA polymerase activity
    		•  0.928091843881235 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.908046791062776 bayes_pls_golite062009
  • microtubule binding
    		•  0.907162506177187 bayes_pls_golite062009
  • transcription activator activity
    		•  0.889929694023098 bayes_pls_golite062009
  • transcription factor activity
    		•  0.887108427603557 bayes_pls_golite062009
  • actin binding
    		•  0.883285269827407 bayes_pls_golite062009
  • structural molecule activity
    		•  0.86514677273731 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.862685397469217 bayes_pls_golite062009
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
    		•  0.8469248456592 bayes_pls_golite062009
  • single-stranded telomeric DNA binding
    		•  0.700780808446722 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.543891899378373 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.421921195209539 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  0.406600732518248 bayes_pls_golite062009
  • protein kinase activity
    		•  0.351308564667977 bayes_pls_golite062009
  • translation regulator activity
    		•  0.29096092258568 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.274994961137851 bayes_pls_golite062009
  • four-way junction helicase activity
    		•  0.26252931460003 bayes_pls_golite062009
  • exodeoxyribonuclease V activity
    		•  0.185603938981231 bayes_pls_golite062009
  • RNA helicase activity
    		•  0.18426050934025 bayes_pls_golite062009
  • transferase activity
    		•  0.175269600441384 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  0.156278588350022 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.147579541298736 bayes_pls_golite062009
  • RNA-dependent ATPase activity
    		•  0.14606996093053 bayes_pls_golite062009
  • mismatched DNA binding
    		•  0.13366911641814 bayes_pls_golite062009
  • ATP-dependent RNA helicase activity
    		•  0.13050483816765 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.113504049290503 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.111293884322157 bayes_pls_golite062009
  • 3'-5' DNA helicase activity
    		•  0.0769112340058804 bayes_pls_golite062009
  • microfilament motor activity
    		•  0.0313060889304495 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  0.0223627159838333 bayes_pls_golite062009
    6 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle