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Protein Overview: mle-PA

General Information:
Name(s) found: mle-PA / FBpp0085367 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene maleless is referred to in FlyBase by the symbol Dmel\mle (CG11680, FBgn0002774). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:1862243..1868277. It has the cytological map location 42A6. There is experimental evidence that it has the molecular function</span>: chromatin binding. There is experimental evidence that it is involved in the biological process</span>: male courtship behavior, veined wing generated song production; determination of adult lifespan; dosage compensation; axon extension. 48 alleles are reported. The phenotypes of these alleles are annotated with: NMJ bouton; polytene chromosome; larval neuromuscular junction; wing; adult brain; spermatozoon. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1293 amino acids

    Gene Ontology:
    Cellular Component: nucleus [NAS]
    X chromosome [IDA]
    chromosome [NAS]
    chromatin [IDA]
    X chromosome located dosage compensation complex, transcription activating [NAS][TAS]
    Biological Process: dosage compensation [IMP][NAS][TAS]
    axon extension [IMP]
    determination of adult lifespan [IMP]
    dosage compensation, by hyperactivation of X chromosome [NAS]
    male courtship behavior, veined wing generated song production [IGI]
    dosage compensation complex assembly involved in dosage compensation by hyperactivation of X chromosome [TAS]
    Molecular Function: ATP binding [IEA]
    RNA helicase activity [NAS]
    double-stranded RNA binding [IEA][ISS]
    ATP-dependent helicase activity [IEA][TAS]
    helicase activity [ISS]
    chromatin binding [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDIKSFLYQF CAKSQIEPKF DIRQTGPKNR QRFLCEVRVE PNTYIGVGNS TNKKDAEKNA  60
   61 CRDFVNYLVR VGKLNTNDVP ADAGASGGGP RTGLEGAGMA GGSGQQKRVF DGQSGPQDLG 120
  121 EAYRPLNHDG GDGGNRYSVI DRIQEQRDMN EAEAFDVNAA IHGNWTIENA KERLNIYKQT 180
  181 NNIRDDYKYT PVGPEHARSF LAELSIYVPA LNRTVTARES GSNKKSASKS CALSLVRQLF 240
  241 HLNVIEPFSG TLKKKKDEQL KPYPVKLSPN LINKIDEVIK GLDLPVVNPR NIKIELDGPP 300
  301 IPLIVNLSRI DSSQQDGEKR QESSVIPWAP PQANWNTWHA CNIDEGELAT TSIDDLSMDY 360
  361 ERSLRDRRQN DNEYRQFLEF REKLPIAAMR SEILTAINDN PVVIIRGNTG CGKTTQIAQY 420
  421 ILDDYICSGQ GGYANIYVTQ PRRISAISVA ERVARERCEQ LGDTVGYSVR FESVFPRPYG 480
  481 AILFCTVGVL LRKLEAGLRG VSHIIVDEIH ERDVNSDFLL VILRDMVDTY PDLHVILMSA 540
  541 TIDTTKFSKY FGICPVLEVP GRAFPVQQFF LEDIIQMTDF VPSAESRRKR KEVEDEEQLL 600
  601 SEDKDEAEIN YNKVCEDKYS QKTRNAMAML SESDVSFELL EALLMHIKSK NIPGAILVFL 660
  661 PGWNLIFALM KFLQNTNIFG DTSQYQILPC HSQIPRDEQR KVFEPVPEGV TKIILSTNIA 720
  721 ETSITIDDIV FVIDICKARM KLFTSHNNLT SYATVWASKT NLEQRKGRAG RVRPGFCFTL 780
  781 CSRARFQALE DNLTPEMFRT PLHEMALTIK LLRLGSIHHF LSKALEPPPV DAVIEAEVLL 840
  841 REMRCLDAND ELTPLGRLLA RLPIEPRLGK MMVLGAVFGC ADLMAIMASY SSTFSEVFSL 900
  901 DIGQRRLANH QKALSGTKCS DHVAMIVASQ MWRREKQRGE HMEARFCDWK GLQMSTMNVI 960
  961 WDAKQQLLDL LQQAGFPEEC MISHEVDERI DGDDPVLDVS LALLCLGLYP NICVHKEKRK1020
 1021 VLTTESKAAL LHKTSVNCSN LAVTFPYPFF VFGEKIRTRA VSCKQLSMVS PLQVILFGSR1080
 1081 KIDLAANNIV RVDNWLNFDI EPELAAKIGA LKPALEDLIT VACDNPSDIL RLEEPYAQLV1140
 1141 KVVKDLCVKS AGDFGLQRES GILPHQSRQF SDGGGPPKRG RFETGRFTNS SFGRRGNGRT1200
 1201 FGGGYGNNGG GYGNNGGGYG NIGGGYGNNA GGYGNNGGYG NNGGGYRNNG GGYGNNGGGY1260
 1261 GNKRGGFGDS FESNRGSGGG FRNGDQGGRW GNF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..132] PSI-BLAST 48.0 Solution structure of the N-terminal dsRBD from hypothetical protein BAB28848
    2 View Details [133..262] PSI-BLAST 18.39794 Double-stranded RNA-binding motif of Hypothetical protein BAB28848
    3 View Details [263..384] PSI-BLAST 8.0 RecG, N-terminal domain; RecG "wedge" domain; RecG helicase domain
    4 View Details [385..993] PSI-BLAST 19.0 No description for 2p6rA was found.
    5 View Details [994..1141] deduced N/A No confident structure predictions are available.
    6 View Details [1142..1293] PSI-BLAST 16.30103 No description for 1y0fB was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • RNA binding
    		•  5.76714029049862 bayes_pls_golite062009
  • binding
    		•  3.86679248145104 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.65107032334139 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  2.92231310035944 bayes_pls_golite062009
  • structural molecule activity
    		•  2.39325095233158 bayes_pls_golite062009
  • DNA binding
    		•  2.1200214740272 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.90221544752436 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.67466835456592 bayes_pls_golite062009
  • DNA strand annealing activity
    		•  1.60999740955835 bayes_pls_golite062009
  • mRNA binding
    		•  1.40322121628626 bayes_pls_golite062009
  • protein binding
    		•  1.33336414936007 bayes_pls_golite062009
  • single-stranded RNA binding
    		•  0.96883475184011 bayes_pls_golite062009
  • double-stranded RNA binding
    		•  0.967560318725736 bayes_pls_golite062009
  • transcription factor activity
    		•  0.94870998048449 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.935558208370217 bayes_pls_golite062009
  • tubulin binding
    		•  0.509012132412818 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.442767995580506 bayes_pls_golite062009
  • microtubule binding
    		•  0.421623912265908 bayes_pls_golite062009
  • transcription activator activity
    		•  0.270384165279764 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.151565749543333 bayes_pls_golite062009
    2
    Term Confidence Notes
  • RNA binding
    		•  5.76714029049862 bayes_pls_golite062009
  • binding
    		•  3.86679248145104 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.65107032334139 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  2.92231310035944 bayes_pls_golite062009
  • structural molecule activity
    		•  2.39325095233158 bayes_pls_golite062009
  • DNA binding
    		•  2.1200214740272 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.90221544752436 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.67466835456592 bayes_pls_golite062009
  • DNA strand annealing activity
    		•  1.60999740955835 bayes_pls_golite062009
  • mRNA binding
    		•  1.40322121628626 bayes_pls_golite062009
  • protein binding
    		•  1.33336414936007 bayes_pls_golite062009
  • single-stranded RNA binding
    		•  0.96883475184011 bayes_pls_golite062009
  • double-stranded RNA binding
    		•  0.967560318725736 bayes_pls_golite062009
  • transcription factor activity
    		•  0.94870998048449 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.935558208370217 bayes_pls_golite062009
  • tubulin binding
    		•  0.509012132412818 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.442767995580506 bayes_pls_golite062009
  • microtubule binding
    		•  0.421623912265908 bayes_pls_golite062009
  • transcription activator activity
    		•  0.270384165279764 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.151565749543333 bayes_pls_golite062009
    3 No functions predicted.
    4
    Term Confidence Notes
  • binding
    		•  3.21663307302451 bayes_pls_golite062009
    		• 2.75349474762373 bayes_pls_golite062009
  • RNA binding
    		•  2.29590582680214 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  2.26294907429933 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.11222585187695 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.90956653286519 bayes_pls_golite062009
  • motor activity
    		•  1.87236631251486 bayes_pls_golite062009
  • microtubule motor activity
    		•  1.73373045248316 bayes_pls_golite062009
  • DNA binding
    		•  1.72568209621547 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.63193306273479 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  1.57653963868443 bayes_pls_golite062009
  • RNA helicase activity
    		•  1.42791449104435 bayes_pls_golite062009
  • RNA-dependent ATPase activity
    		•  1.39335733374328 bayes_pls_golite062009
  • ATP-dependent RNA helicase activity
    		•  1.36724390116598 bayes_pls_golite062009
  • hydrolase activity
    		•  1.35992428696151 bayes_pls_golite062009
  • protein-DNA loading ATPase activity
    		•  1.13453756785987 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.03255157977314 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • DNA clamp loader activity
    		•  0.901695948462601 bayes_pls_golite062009
  • mRNA binding
    		•  0.76699944561918 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.762584163889896 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.75415390146713 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.720765886383727 bayes_pls_golite062009
  • helicase activity
    		•  0.6191010101321 bayes_pls_golite062009
  • structural molecule activity
    		•  0.596382945962261 bayes_pls_golite062009
  • transcription factor activity
    		•  0.567932466447757 bayes_pls_golite062009
  • tubulin binding
    		•  0.542033490752996 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.49000746592281 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.461763181659193 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.458831409927227 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.455976987338331 bayes_pls_golite062009
  • microtubule binding
    		•  0.444074831514397 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.422944846459286 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  0.41398614759796 bayes_pls_golite062009
  • actin binding
    		•  0.351722091343607 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  0.29664013896754 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  0.29664013896754 bayes_pls_golite062009
  • microfilament motor activity
    		•  0.26523838851913 bayes_pls_golite062009
  • nucleotide binding
    		•  0.114848452385726 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.10713474095071 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.0916519414118148 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.0915913646217636 bayes_pls_golite062009
  • protein binding
    		•  0.071010918255742 bayes_pls_golite062009
  • histone methyltransferase activity (H3-K9 specific)
    		•  0.0383107114295358 bayes_pls_golite062009
    5 No functions predicted.
    6 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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