| Protein: | mle-PA |
| Organism: | Drosophila melanogaster |
| Length: | 1293 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for mle-PA.
| Description | E-value | Query Range |
Subject Range |
|
|
1095.0 | [0..1] | [1200..1] |
|
Region A: Residues: [1-132] |
1 11 21 31 41 51
| | | | | |
1 MDIKSFLYQF CAKSQIEPKF DIRQTGPKNR QRFLCEVRVE PNTYIGVGNS TNKKDAEKNA 60
61 CRDFVNYLVR VGKLNTNDVP ADAGASGGGP RTGLEGAGMA GGSGQQKRVF DGQSGPQDLG 120
121 EAYRPLNHDG GD
|
| Detection Method: |  |
| Confidence: | 48.0 |
| Match: | 1whqA |
| Description: | Solution structure of the N-terminal dsRBD from hypothetical protein BAB28848 |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| RNA binding | 5.76714029049862 | bayes_pls_golite062009 |
| binding | 3.86679248145104 | bayes_pls_golite062009 |
| nucleic acid binding | 3.65107032334139 | bayes_pls_golite062009 |
| structural constituent of ribosome | 2.92231310035944 | bayes_pls_golite062009 |
| structural molecule activity | 2.39325095233158 | bayes_pls_golite062009 |
| DNA binding | 2.1200214740272 | bayes_pls_golite062009 |
| transcription regulator activity | 1.90221544752436 | bayes_pls_golite062009 |
| transcription repressor activity | 1.67466835456592 | bayes_pls_golite062009 |
| DNA strand annealing activity | 1.60999740955835 | bayes_pls_golite062009 |
| mRNA binding | 1.40322121628626 | bayes_pls_golite062009 |
| protein binding | 1.33336414936007 | bayes_pls_golite062009 |
| single-stranded RNA binding | 0.96883475184011 | bayes_pls_golite062009 |
| double-stranded RNA binding | 0.967560318725736 | bayes_pls_golite062009 |
| transcription factor activity | 0.94870998048449 | bayes_pls_golite062009 |
| cytoskeletal protein binding | 0.935558208370217 | bayes_pls_golite062009 |
| tubulin binding | 0.509012132412818 | bayes_pls_golite062009 |
| DNA-dependent ATPase activity | 0.442767995580506 | bayes_pls_golite062009 |
| microtubule binding | 0.421623912265908 | bayes_pls_golite062009 |
| transcription activator activity | 0.270384165279764 | bayes_pls_golite062009 |
| structure-specific DNA binding | 0.151565749543333 | bayes_pls_golite062009 |
|
Region A: Residues: [133-262] |
1 11 21 31 41 51
| | | | | |
1 GGNRYSVIDR IQEQRDMNEA EAFDVNAAIH GNWTIENAKE RLNIYKQTNN IRDDYKYTPV 60
61 GPEHARSFLA ELSIYVPALN RTVTARESGS NKKSASKSCA LSLVRQLFHL NVIEPFSGTL 120
121 KKKKDEQLKP
|
| Detection Method: | |
| Confidence: | 18.39794 |
| Match: | 1uilA |
| Description: | Double-stranded RNA-binding motif of Hypothetical protein BAB28848 |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| RNA binding | 5.76714029049862 | bayes_pls_golite062009 |
| binding | 3.86679248145104 | bayes_pls_golite062009 |
| nucleic acid binding | 3.65107032334139 | bayes_pls_golite062009 |
| structural constituent of ribosome | 2.92231310035944 | bayes_pls_golite062009 |
| structural molecule activity | 2.39325095233158 | bayes_pls_golite062009 |
| DNA binding | 2.1200214740272 | bayes_pls_golite062009 |
| transcription regulator activity | 1.90221544752436 | bayes_pls_golite062009 |
| transcription repressor activity | 1.67466835456592 | bayes_pls_golite062009 |
| DNA strand annealing activity | 1.60999740955835 | bayes_pls_golite062009 |
| mRNA binding | 1.40322121628626 | bayes_pls_golite062009 |
| protein binding | 1.33336414936007 | bayes_pls_golite062009 |
| single-stranded RNA binding | 0.96883475184011 | bayes_pls_golite062009 |
| double-stranded RNA binding | 0.967560318725736 | bayes_pls_golite062009 |
| transcription factor activity | 0.94870998048449 | bayes_pls_golite062009 |
| cytoskeletal protein binding | 0.935558208370217 | bayes_pls_golite062009 |
| tubulin binding | 0.509012132412818 | bayes_pls_golite062009 |
| DNA-dependent ATPase activity | 0.442767995580506 | bayes_pls_golite062009 |
| microtubule binding | 0.421623912265908 | bayes_pls_golite062009 |
| transcription activator activity | 0.270384165279764 | bayes_pls_golite062009 |
| structure-specific DNA binding | 0.151565749543333 | bayes_pls_golite062009 |
|
Region A: Residues: [263-384] |
1 11 21 31 41 51
| | | | | |
1 YPVKLSPNLI NKIDEVIKGL DLPVVNPRNI KIELDGPPIP LIVNLSRIDS SQQDGEKRQE 60
61 SSVIPWAPPQ ANWNTWHACN IDEGELATTS IDDLSMDYER SLRDRRQNDN EYRQFLEFRE 120
121 KL
|
| Detection Method: | |
| Confidence: | 8.0 |
| Match: | 1gm5A |
| Description: | RecG, N-terminal domain; RecG "wedge" domain; RecG helicase domain |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [385-993] |
1 11 21 31 41 51
| | | | | |
1 PIAAMRSEIL TAINDNPVVI IRGNTGCGKT TQIAQYILDD YICSGQGGYA NIYVTQPRRI 60
61 SAISVAERVA RERCEQLGDT VGYSVRFESV FPRPYGAILF CTVGVLLRKL EAGLRGVSHI 120
121 IVDEIHERDV NSDFLLVILR DMVDTYPDLH VILMSATIDT TKFSKYFGIC PVLEVPGRAF 180
181 PVQQFFLEDI IQMTDFVPSA ESRRKRKEVE DEEQLLSEDK DEAEINYNKV CEDKYSQKTR 240
241 NAMAMLSESD VSFELLEALL MHIKSKNIPG AILVFLPGWN LIFALMKFLQ NTNIFGDTSQ 300
301 YQILPCHSQI PRDEQRKVFE PVPEGVTKII LSTNIAETSI TIDDIVFVID ICKARMKLFT 360
361 SHNNLTSYAT VWASKTNLEQ RKGRAGRVRP GFCFTLCSRA RFQALEDNLT PEMFRTPLHE 420
421 MALTIKLLRL GSIHHFLSKA LEPPPVDAVI EAEVLLREMR CLDANDELTP LGRLLARLPI 480
481 EPRLGKMMVL GAVFGCADLM AIMASYSSTF SEVFSLDIGQ RRLANHQKAL SGTKCSDHVA 540
541 MIVASQMWRR EKQRGEHMEA RFCDWKGLQM STMNVIWDAK QQLLDLLQQA GFPEECMISH 600
601 EVDERIDGD
|
| Detection Method: | |
| Confidence: | 19.0 |
| Match: | 2p6rA |
| Description: | No description for 2p6rA was found. |
| Term | Confidence | Notes |
| binding | 3.21663307302451 | bayes_pls_golite062009 |
| 2.75349474762373 | bayes_pls_golite062009 | |
| RNA binding | 2.29590582680214 | bayes_pls_golite062009 |
| DNA-dependent ATPase activity | 2.26294907429933 | bayes_pls_golite062009 |
| nucleic acid binding | 2.11222585187695 | bayes_pls_golite062009 |
| general RNA polymerase II transcription factor activity | 1.90956653286519 | bayes_pls_golite062009 |
| motor activity | 1.87236631251486 | bayes_pls_golite062009 |
| microtubule motor activity | 1.73373045248316 | bayes_pls_golite062009 |
| DNA binding | 1.72568209621547 | bayes_pls_golite062009 |
| transcription regulator activity | 1.63193306273479 | bayes_pls_golite062009 |
| structural constituent of ribosome | 1.57653963868443 | bayes_pls_golite062009 |
| RNA helicase activity | 1.42791449104435 | bayes_pls_golite062009 |
| RNA-dependent ATPase activity | 1.39335733374328 | bayes_pls_golite062009 |
| ATP-dependent RNA helicase activity | 1.36724390116598 | bayes_pls_golite062009 |
| hydrolase activity | 1.35992428696151 | bayes_pls_golite062009 |
| protein-DNA loading ATPase activity | 1.13453756785987 | bayes_pls_golite062009 |
| cytoskeletal protein binding | 1.03255157977314 | bayes_pls_golite062009 |
| catalytic activity | 1.00104173493322 | bayes_pls_golite062009 |
| DNA clamp loader activity | 0.901695948462601 | bayes_pls_golite062009 |
| mRNA binding | 0.76699944561918 | bayes_pls_golite062009 |
| structure-specific DNA binding | 0.762584163889896 | bayes_pls_golite062009 |
| DNA helicase activity | 0.75415390146713 | bayes_pls_golite062009 |
| transcription repressor activity | 0.720765886383727 | bayes_pls_golite062009 |
| helicase activity | 0.6191010101321 | bayes_pls_golite062009 |
| structural molecule activity | 0.596382945962261 | bayes_pls_golite062009 |
| transcription factor activity | 0.567932466447757 | bayes_pls_golite062009 |
| tubulin binding | 0.542033490752996 | bayes_pls_golite062009 |
| double-stranded DNA binding | 0.49000746592281 | bayes_pls_golite062009 |
| hydrolase activity, acting on acid anhydrides | 0.461763181659193 | bayes_pls_golite062009 |
| hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 0.458831409927227 | bayes_pls_golite062009 |
| pyrophosphatase activity | 0.455976987338331 | bayes_pls_golite062009 |
| microtubule binding | 0.444074831514397 | bayes_pls_golite062009 |
| nucleoside-triphosphatase activity | 0.422944846459286 | bayes_pls_golite062009 |
| ATP-dependent DNA helicase activity | 0.41398614759796 | bayes_pls_golite062009 |
| actin binding | 0.351722091343607 | bayes_pls_golite062009 |
| purine NTP-dependent helicase activity | 0.29664013896754 | bayes_pls_golite062009 |
| ATP-dependent helicase activity | 0.29664013896754 | bayes_pls_golite062009 |
| microfilament motor activity | 0.26523838851913 | bayes_pls_golite062009 |
| nucleotide binding | 0.114848452385726 | bayes_pls_golite062009 |
| purine nucleotide binding | 0.10713474095071 | bayes_pls_golite062009 |
| purine ribonucleotide binding | 0.0916519414118148 | bayes_pls_golite062009 |
| ribonucleotide binding | 0.0915913646217636 | bayes_pls_golite062009 |
| protein binding | 0.071010918255742 | bayes_pls_golite062009 |
| histone methyltransferase activity (H3-K9 specific) | 0.0383107114295358 | bayes_pls_golite062009 |
|
Region A: Residues: [994-1141] |
1 11 21 31 41 51
| | | | | |
1 DPVLDVSLAL LCLGLYPNIC VHKEKRKVLT TESKAALLHK TSVNCSNLAV TFPYPFFVFG 60
61 EKIRTRAVSC KQLSMVSPLQ VILFGSRKID LAANNIVRVD NWLNFDIEPE LAAKIGALKP 120
121 ALEDLITVAC DNPSDILRLE EPYAQLVK
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [1142-1293] |
1 11 21 31 41 51
| | | | | |
1 VVKDLCVKSA GDFGLQRESG ILPHQSRQFS DGGGPPKRGR FETGRFTNSS FGRRGNGRTF 60
61 GGGYGNNGGG YGNNGGGYGN IGGGYGNNAG GYGNNGGYGN NGGGYRNNGG GYGNNGGGYG 120
121 NKRGGFGDSF ESNRGSGGGF RNGDQGGRWG NF
|
| Detection Method: | |
| Confidence: | 16.30103 |
| Match: | 1y0fB |
| Description: | No description for 1y0fB was found. |
