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Protein Overview: INS2_RAT

General Information:
Name(s) found: INS2_RAT [Swiss-Prot]
Description(s) found:
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  • gi|9506817|ref|NP_062003.1| insulin 2 [Rattus norvegicus] [NCBI NR]
  • pir||IPRT2 insulin 2 precursor - rat [NCBI NR]
  • gi|56490|emb|CAA24560.1| preproinsulin [Rattus norvegicus] [NCBI NR]
  • gi|204959|gb|AAA41443.1| preproinsulin II [NCBI NR]
  • gi|204952|gb|AAA41440.1| insulin 2 [NCBI NR]
  • gi|149061739|gb|EDM12162.1| rCG48472 [Rattus norvegicus] [NCBI NR]
  • gi|124520|sp|P01323.1|INS2_RAT RecName: Full=Insulin-2; Contains: RecName: Full=Insulin-2 B chain; Contains: RecName: Full=Insulin-2 A chain; Flags: Precursor [NCBI NR]
  • Insulin-2 OS=Rattus norvegicus GN=Ins2 PE=1 SV=1 [Swiss-Prot]
  • Ensembl_locations(Chr-bp):1-202582827 Insulin 2 precursor [hmr_yeast5_DM3-1_pombe.fasta]
  • insulin 2 [HMR_022704-rand.fasta]
  • insulin 2 [Rattus norvegicus]gi|56490|emb|CAA24560.1| preproinsulin [Rattus norvegicus]gi|124520|sp|P01323|INS2_RAT Insulin 2 precursorgi|69315|pir||IPRT2 insulin 2 precursor - ratgi|204959|gb|AAA41443.1| preproinsulin IIgi|204952|gb|AAA41440.1| insu [nrdb_11152004_Chlamydomonas]
  • Tax_Id=10116 Insulin-2 precursor [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta]
  • (NM_019130) insulin 2 [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • Tax_Id=10116 Insulin 2 precursor [EBI-IPI_rat_3.05_04-04-2005_origrev.fasta]
  • Insulin-2 precursor [Contains: Insulin-2 B chain; Insulin-2 A chain] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • insulin 2 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • rCG48472 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • preproinsulin [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • preproinsulin II [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10116 INSULIN 2 PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=10116 Gene_Symbol=Ins2 Insulin-2 [rat-ipi-250309-contam.fasta]
  • Insulin-2 OS=Rattus norvegicus GN=Ins2 [011711_HMR.fasta]
    • Organism: Rattus norvegicus
    Length: 110 amino acids

    Gene Ontology:
    Cellular Component: nucleus [UNKNOWN][IEA]
    extracellular space [UNKNOWN][IDA]
    soluble fraction [IDA]
    cytoplasm [UNKNOWN][IEA]
    secretory granule [UNKNOWN][IDA]
    extracellular region [UNKNOWN][IEA]
    small nucleolar ribonucleoprotein complex [UNKNOWN][IEA]
    Biological Process: positive regulation of cellular protein metabolic process [UNKNOWN]
    positive regulation of phosphoinositide 3-kinase cascade [UNKNOWN]
    negative regulation of respiratory burst involved in inflammatory response [UNKNOWN]
    insulin receptor signaling pathway [UNKNOWN][IEA]
    positive regulation of cell proliferation [UNKNOWN]
    [NOT]activation of JUN kinase activity [UNKNOWN]
    negative regulation of protein catabolic process [UNKNOWN]
    positive regulation of DNA replication [UNKNOWN]
    negative regulation of proteolysis [UNKNOWN]
    alpha-beta T cell activation [UNKNOWN]
    positive regulation of mitosis [UNKNOWN]
    glucose metabolic process [UNKNOWN][IEA]
    negative regulation of fatty acid metabolic process [UNKNOWN]
    positive regulation of glycogen biosynthetic process [UNKNOWN]
    positive regulation of NF-kappaB transcription factor activity [UNKNOWN]
    regulation of cellular amino acid metabolic process [UNKNOWN]
    ER overload response [UNKNOWN][IEA]
    positive regulation of glycolysis [UNKNOWN]
    negative regulation of transcription from RNA polymerase II promoter [UNKNOWN][IEA]
    MAPKKK cascade [UNKNOWN]
    activation of MAPK activity [UNKNOWN]
    wound healing [UNKNOWN]
    positive regulation of cytokine secretion [UNKNOWN]
    activation of protein kinase B activity [UNKNOWN]
    positive regulation of peptidyl-tyrosine phosphorylation [UNKNOWN]
    biological_process [ND]
    positive regulation of insulin receptor signaling pathway [UNKNOWN]
    G-protein coupled receptor protein signaling pathway [UNKNOWN]
    regulation of protein secretion [UNKNOWN]
    regulation of protein localization [UNKNOWN]
    negative regulation of protein secretion [UNKNOWN]
    negative regulation of glycogen catabolic process [UNKNOWN]
    fatty acid homeostasis [UNKNOWN]
    regulation of transmembrane transporter activity [UNKNOWN]
    positive regulation of glucose import [UNKNOWN]
    regulation of apoptosis [UNKNOWN][IEA]
    positive regulation of MAPKKK cascade [UNKNOWN]
    respiratory burst [UNKNOWN]
    acute-phase response [UNKNOWN]
    regulation of phosphorylation [UNKNOWN][IEA]
    negative regulation of acute inflammatory response [UNKNOWN]
    carbohydrate metabolic process [IEA]
    lipid catabolic process [UNKNOWN][IEA]
    glucose homeostasis [UNKNOWN]
    negative regulation of NAD(P)H oxidase activity [UNKNOWN]
    glucose transport [UNKNOWN]
    positive regulation of protein kinase B signaling cascade [UNKNOWN]
    Molecular Function: protein binding [UNKNOWN]
    protease binding [IPI]
    insulin receptor binding [UNKNOWN]
    protein complex binding [IPI]
    hormone activity [UNKNOWN][IEA]
    insulin-like growth factor receptor binding [UNKNOWN]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALWIRFLPL LALLILWEPR PAQAFVKQHL CGSHLVEALY LVCGERGFFY TPMSRREVED  60
   61 PQVAQLELGG GPGAGDLQTL ALEVARQKRG IVDQCCTSIC SLYQLENYCN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..110] PSI-BLAST 15.30103 Insulin


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle