Protein Overview: M3K1_RAT

General Information:
Name(s) found:	M3K1_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	pir\|\|T10757 MAP kinase kinase (EC 2.7.1.-) 1 - rat [NCBI NR] gi\|2499638\|sp\|Q62925.1\|M3K1_RAT RecName: Full=Mitogen-activated protein kinase kinase kinase 1; AltName: Full=MAPK/ERK kinase kinase 1; Short=MEK kinase 1; Short=MEKK 1 [NCBI NR] gi\|16758760\|ref\|NP_446339.1\| mitogen-activated protein kinase kinase kinase 1 [Rattus norvegicus] [NCBI NR] gi\|1354137\|gb\|AAC52596.1\| MAP kinase kinase kinase 1 [NCBI NR] Mitogen-activated protein kinase kinase kinase 1 OS=Rattus norvegicus GN=Map3k1 PE=1 SV=1 [Swiss-Prot] Ensembl_locations(Chr-bp):2-39091878 Mitogen-activated protein kinase kinase kinase 1 [hmr_yeast5_DM3-1_pombe.fasta] mitogen activated protein kinase kinase kinase 1 [HMR_022704-rand.fasta] mitogen activated protein kinase kinase kinase 1 [Rattus norvegicus]gi\|1354137\|gb\|AAC52596.1\| MAP kinase kinase kinase 1gi\|7514007\|pir\|\|T10757 MAP kinase kinase (EC 2.7.1.-) 1 - ratgi\|2499638\|sp\|Q62925\|M3K1_RAT Mitogen-activated protein kinase kinase k [nrdb_11152004_Chlamydomonas] Tax_Id=10116 Mitogen-activated protein kinase kinase kinase 1 [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] (NM_053887) mitogen activated protein kinase kinase kinase 1 [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] mitogen activated protein kinase kinase kinase 1 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Mitogen-activated protein kinase kinase kinase 1 (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] MAP kinase kinase kinase 1 [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] mitogen-activated protein kinase kinase kinase 1 [Rattus norvegicus] [NCBI-RefSeq_human-rat_na_04-07-2009_con_reversed.fasta] Tax_Id=10116 Gene_Symbol=Map3k1 Mitogen-activated protein kinase kinase kinase 1 [rat-ipi-250309-contam.fasta] Mitogen-activated protein kinase kinase kinase 1 OS=Rattus norvegicus GN=Map3k1 [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	1493 amino acids
Gene Ontology:
Cellular Component:	membrane fraction [IDA] cytoskeleton [IDA] cytoplasm [IDA] membrane [IEA] cytosol [UNKNOWN]
Biological Process:	positive regulation of MAP kinase activity [IDA] positive regulation of JUN kinase activity [IDA] transforming growth factor beta receptor signaling pathway [UNKNOWN][IEA] activation of JNKK activity [IDA] activation of JUN kinase activity [UNKNOWN][IEA] protein amino acid autophosphorylation [IDA][IMP] JNK cascade [UNKNOWN] protein amino acid phosphorylation [IDA][IEA] MAPKKK cascade [IDA][IEA] activation of MAPKK activity [IDA] wound healing [UNKNOWN][IEA] apoptotic mitochondrial changes [UNKNOWN][IEA] camera-type eye development [UNKNOWN][IEA] positive regulation of gene-specific transcription from RNA polymerase II promoter [IDA] positive regulation of viral transcription [IDA] protein polyubiquitination [IMP] response to osmotic stress [IMP] I-kappaB kinase/NF-kappaB cascade [UNKNOWN] protein ubiquitination during ubiquitin-dependent protein catabolic process [IGI] positive regulation of actin filament polymerization [UNKNOWN][IEA] positive regulation of apoptosis [IMP] negative regulation of actin filament bundle assembly [IDA] peptidyl-serine phosphorylation [IDA] regulation of cell migration [UNKNOWN][IEA] protein oligomerization [IDA]
Molecular Function:	protein kinase binding [UNKNOWN] zinc ion binding [IEA] identical protein binding [IPI] protein kinase activity [UNKNOWN] JUN kinase binding [IPI] protein serine/threonine kinase activity [IEA] JUN kinase kinase activity [UNKNOWN][IEA] sphingolipid binding [IPI] nucleotide binding [IEA] magnesium ion binding [IEA] MAP/ERK kinase kinase activity [IDA] ubiquitin-protein ligase activity [IMP] ATP binding [IEA] protein binding [UNKNOWN][IEA][IPI] JUN kinase kinase kinase activity [IDA] MAP kinase kinase kinase activity [IEA] transferase activity [IEA] mitogen-activated protein kinase binding [IPI] mitogen-activated protein kinase kinase binding [IPI]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAAAGDRAS SSGFPGAAAA SPEAGGGGGA LQGSGAPAAG AGLLRETGSA GRERADWRRQ  60
   61 QLRKVRSVEL DQLPEQPLFL TASPPCPSTS PSPEPADAAA GASGFQPAAG PPPPGAASRC 120
  121 GSHSAELAAA RDSGARSPAG AEPPSAAAPS GREMENKETL KGLHKMDDRP EERMIREKLK 180
  181 ATCMPAWKHE WLERRNRRGP VVVKPIPIKG DGSEMSNLAA ELQGEGQAGS AAPAPKGRRS 240
  241 PSPGSSPSGR SGKPESPGVR RKRVSPVPFQ SGRITPPRRA PSPDGFSPYS PEETSRRVNK 300
  301 VMRARLYLLQ QIGPNSFLIG GDSPDNKYRV FIGPQNCSCG RGTFCIHLLF VMLRVFQLEP 360
  361 SDPMLWRKTL KNFEVESLFQ KYHSRRSSRI KAPSRNTIQK FVSRMSNCHT LSSSSTSTSS 420
  421 SENSIKDEEE QMCPICLLGM LDEESLTVCE DGCRNKLHHH CMSIWAEECR RNREPLICPL 480
  481 CRSKWRSHDF YSHELSSPVD SPTSLRGVQQ PSSPQQPVAG SQRRNQESNF NLTHYGTQQI 540
  541 PPAYKDLAEP WIQAFGMELV GCLFSRNWNV REMALRRLSH DVSGALLLAN GESTGTSGGG 600
  601 SGGSLSAGAA SGSSQPSISG DVVEAFCSVL SIVCADPVYK VYVAALKTLR AMLVYTPCHS 660
  661 LAERIKLQRL LRPVVDTILV KCADANSRTS QLSISTLLEL CKGQAGELAV GREILKAGSI 720
  721 GVGGVDYVLS CILGNQAESN NWQELLGRLC LIDRLLLEIS AEFYPHIVST DVSQAEPVEI 780
  781 RYKKLLSLLA FALQSIDNSH SMVGKLSRRI YLSSARMVTT VPPLFSKLVT MLSASGSSHF 840
  841 ARMRRRLMAI ADEVEIAEVI QLGSEDTLDG QQDSSQALAP PRYPESSSLE HTAHVEKTGK 900
  901 GLKATRLSAS SEDISDRLAG VSVGLPSSAT TEQPKPTVQT KGRPHSQCLN SSPLSPPQLM 960
  961 FPAISAPCSS APSVPAGSVT DASKHRPRAF VPCKIPSASP QTQRKFSLQF QRTCSENRDS1020
 1021 EKLSPVFTQS RPPPSSNIHR AKASRPVPGS TSKLGDASKN SMTLDLNSAS QCDDSFGSGS1080
 1081 NSGSAVIPSE ETAFTPAEDK CRLDVNPELN SSIEDLLEAS MPSSDTTVTF KSEVAVLSPE1140
 1141 KAESDDTYKD DVNHNQKCKE KMEAEEEEAL AIAMAMSASQ DALPIVPQLQ VENGEDIIII1200
 1201 QQDTPETLPG HTKANEPYRE DTEWLKGQQI GLGAFSSCYQ AQDVGTGTLM AVKQVTYVRN1260
 1261 TSSEQEEVVE ALREEIRMMS HLNHPNIIRM LGATCEKSNY NLFIEWMAGA SVAHLLSKYG1320
 1321 AFKESVVINY TEQLLRGLSY LHENQIIHRD VKGANLLIDS TGQRLRIADF GAAARLASKG1380
 1381 TGAGEFQGQL LGTIAFMAPE VLRGQQYGRS CDVWSVGCAI IEMACAKPPW NAEKHSNHLA1440
 1441 LIFKIASATT APSIPSHLSP GLRDVALRCL ELQPQDRPPS RELLKHPVFR TTW

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.53

Protein Overview: M3K1_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: