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Protein Overview: HMGB1_RAT

General Information:
Name(s) found: HMGB1_RAT [Swiss-Prot]
Description(s) found:
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  • gi|9082303|gb|AAF82799.1|AF275734_1 amphoterin [Rattus norvegicus] [NCBI NR]
  • pir||NSRTH1 nonhistone chromosomal protein HMG-1 - rat [NCBI NR]
  • gi|6981026|ref|NP_037095.1| high mobility group box 1 [Rattus norvegicus] [NCBI NR]
  • gi|56788766|gb|AAH88402.1| High mobility group box 1 [Rattus norvegicus] [NCBI NR]
  • gi|56365|emb|CAA68526.1| unnamed protein product [Rattus norvegicus] [NCBI NR]
  • gi|52783618|sp|P63159.2|HMGB1_RAT RecName: Full=High mobility group protein B1; AltName: Full=High mobility group protein 1; Short=HMG-1; AltName: Full=Amphoterin; AltName: Full=Heparin-binding protein p30 [NCBI NR]
  • gi|51859468|gb|AAH81839.1| High mobility group box 1 [Rattus norvegicus] [NCBI NR]
  • gi|38512146|gb|AAH61779.1| High mobility group box 1 [Rattus norvegicus] [NCBI NR]
  • gi|202885|gb|AAA40729.1| Amphoterin [NCBI NR]
  • gi|195539712|gb|AAI68143.1| High mobility group box 1 [Rattus norvegicus] [NCBI NR]
  • gi|149034813|gb|EDL89533.1| rCG42800, isoform CRA_a [Rattus norvegicus] [NCBI NR]
  • gi|149034812|gb|EDL89532.1| rCG42800, isoform CRA_a [Rattus norvegicus] [NCBI NR]
  • gi|149034811|gb|EDL89531.1| rCG42800, isoform CRA_a [Rattus norvegicus] [NCBI NR]
  • High mobility group protein B1 OS=Rattus norvegicus GN=Hmgb1 PE=1 SV=2 [Swiss-Prot]
  • Ensembl_locations(Chr-bp):7-136546290;1-172014620;1-249219463;1-249240507 high mobility group box 1 [hmr_yeast5_DM3-1_pombe.fasta]
  • high mobility group box 1; high mobility group 1 [HMR_022704-rand.fasta]
  • High mobility group box 1 [Mus musculus]gi|54648288|gb|AAH85090.1| High mobility group box 1 [Mus musculus]gi|6981026|ref|NP_037095.1| high mobility group box 1 [Rattus norvegicus]gi|6754208|ref|NP_034569.1| high mobility group box 1 [Mus musculus]gi| [nrdb_11152004_Chlamydomonas]
  • (NM_012963) high mobility group 1; High mobility group box 1 [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • High mobility group protein B1 (High mobility group protein 1) (HMG-1) (Amphoterin) (Heparin-binding protein p30) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • high mobility group box 1 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • rCG42800, isoform CRA_a [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • High mobility group box 1 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • amphoterin [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • unnamed protein product [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Amphoterin [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10116 HIGH MOBILITY GROUP BOX 1 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=10116 Gene_Symbol=Hmgb1 High mobility group protein B1 [rat-ipi-250309-contam.fasta]
  • High mobility group protein B1 OS=Rattus norvegicus GN=Hmgb1 [011711_HMR.fasta]
  • High mobility group box 1 OS=Rattus norvegicus GN=Hmgb1 [011711_HMR.fasta]
    • Organism: Rattus norvegicus
    Length: 215 amino acids

    Gene Ontology:
    Cellular Component: condensed chromosome [UNKNOWN]
    nucleus [UNKNOWN][IDA][IEA]
    extracellular space [UNKNOWN][IDA]
    soluble fraction [UNKNOWN]
    cytoplasm [UNKNOWN][IDA]
    transcriptional repressor complex [UNKNOWN]
    nucleolus [UNKNOWN]
    neuron projection [UNKNOWN]
    nucleoplasm [UNKNOWN]
    cell surface [UNKNOWN]
    Biological Process: positive regulation of cell proliferation [IDA]
    base-excision repair, DNA ligation [UNKNOWN]
    nervous system development [IMP]
    positive regulation of myoblast differentiation [IMP]
    positive regulation of DNA binding [UNKNOWN]
    positive regulation of transcription from RNA polymerase II promoter [UNKNOWN]
    negative regulation of transcription from RNA polymerase II promoter [UNKNOWN]
    chemotaxis [IDA]
    response to heat [IEP]
    response to glucose stimulus [IEP]
    response to insulin stimulus [IEP]
    inflammatory response to antigenic stimulus [UNKNOWN]
    response to glucocorticoid stimulus [UNKNOWN]
    positive regulation of neuron projection development [IMP]
    positive regulation of smooth muscle cell migration [IMP]
    positive regulation of gene-specific transcription from RNA polymerase II promoter [UNKNOWN]
    actin cytoskeleton reorganization [IMP]
    lung development [UNKNOWN]
    male-specific defense response to bacterium [IDA]
    V(D)J recombination [UNKNOWN]
    positive regulation of myeloid cell differentiation [UNKNOWN]
    positive regulation of myeloid cell apoptosis [IDA]
    cell morphogenesis [IMP]
    response to interferon-gamma [IMP]
    positive regulation of glycogen catabolic process [UNKNOWN]
    negative regulation of DNA replication [IDA]
    circadian rhythm [IEP]
    regulation of transcription from RNA polymerase II promoter [UNKNOWN]
    positive regulation of caspase activity [UNKNOWN]
    eye development [UNKNOWN]
    response to drug [IEP]
    positive regulation of protein amino acid phosphorylation [UNKNOWN]
    positive regulation of apoptosis [UNKNOWN][IMP]
    myoblast proliferation [IMP]
    negative regulation of RNA polymerase II transcriptional preinitiation complex assembly [UNKNOWN]
    cellular response to interleukin-1 [IEP]
    regulation of inflammatory response [IDA]
    response to lipopolysaccharide [IEP]
    positive regulation of cell death [IMP]
    Molecular Function: protein kinase activator activity [UNKNOWN]
    5S rRNA binding [IDA]
    double-stranded DNA binding [IDA]
    DNA bending activity [UNKNOWN][IDA]
    heparin binding [IDA][TAS]
    protein dimerization activity [IDA]
    transcription factor binding [UNKNOWN]
    cytokine activity [UNKNOWN]
    four-way junction DNA binding [IDA]
    single-stranded DNA binding [IDA]
    DNA binding [IEA]
    transcription factor activity [UNKNOWN]
    protein binding [UNKNOWN][IDA][IPI]
    glycolipid binding [IDA]
    transcription repressor binding [UNKNOWN]
    calcium-dependent protein kinase regulator activity [UNKNOWN]
    RAGE receptor binding [IMP]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGKGDPKKPR GKMSSYAFFV QTCREEHKKK HPDASVNFSE FSKKCSERWK TMSAKEKGKF  60
   61 EDMAKADKAR YEREMKTYIP PKGETKKKFK DPNAPKRPPS AFFLFCSEYR PKIKGEHPGL 120
  121 SIGDVAKKLG EMWNNTAADD KQPYEKKAAK LKEKYEKDIA AYRAKGKPDA AKKGVVKAEK 180
  181 SKKKKEEEDD EEDEEDEEEE EEEEDEDEEE DDDDE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..215] PSI-BLAST 26.522879 No description for 2gzkA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  0.927928103499335 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.38664561645052 bayes_pls_golite062009
  • DNA binding
    		•  0.37554038880732 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle