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The process by which immune receptor genes are diversified through recombination of the germline genetic elements within a single genetic locus. The process by which immune receptor V, D, and J, or V and J gene segments, depending on the specific receptor, are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS). The process by which immunoglobulin gene segments are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS). For immunoglobulin heavy chains V, D, and J gene segments are joined, and for immunoglobulin light chains V and J gene segments are joined. The process by which T cell receptor V, D, and J, or V and J gene segments, depending on the specific locus, are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS). Recombination occurring within or between DNA molecules in somatic cells. The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: V(D)J recombination
Acc: GO:0033151
Aspect: Biological Process
Desc: The process by which immune receptor V, D, and J, or V and J gene segments, depending on the specific receptor, are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS).
Synonyms:
  • V-J recombination
  • V(D)J joining
  • V-D-J joining
  • V-D-J recombination
  • V-J joining
Proteins in PDR annotated with:
   This term: 16 [Search]
   Term or descendants: 26 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0033151 - V(D)J recombination (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle