Protein Overview: KPCA_RAT

General Information:
Name(s) found:	KPCA_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	pir\|\|KIRTC protein kinase C (EC 2.7.1.-) alpha - rat [NCBI NR] gi\|197246473\|gb\|AAI69007.1\| Prkca protein [Rattus norvegicus] [NCBI NR] gi\|125552\|sp\|P05696.3\|KPCA_RAT RecName: Full=Protein kinase C alpha type; Short=PKC-alpha; Short=PKC-A [NCBI NR] gi\|109492115\|ref\|XP_001081588.1\| PREDICTED: similar to Protein kinase C alpha type (PKC-alpha) (PKC-A) [Rattus norvegicus] [NCBI NR] Protein kinase C alpha type OS=Rattus norvegicus GN=Prkca PE=1 SV=3 [Swiss-Prot] Ensembl_locations(Chr-bp):10-95597876 Protein kinase C, alpha type [hmr_yeast5_DM3-1_pombe.fasta] unnamed protein product [Rattus rattus]gi\|66716\|pir\|\|KIRTC protein kinase C (EC 2.7.1.-) alpha - ratgi\|125552\|sp\|P05696\|KPCA_RAT Protein kinase C, alpha type (PKC-alpha) (PKC-A) [nrdb_11152004_Chlamydomonas] Protein kinase C alpha type (PKC-alpha) (PKC-A) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 PROTEIN KINASE C, ALPHA TYPE [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] PREDICTED: similar to Protein kinase C alpha type (PKC-alpha) (PKC-A) [Rattus norvegicus] [nr-271106-contam.fasta] Tax_Id=10116 Gene_Symbol=Prkca Protein kinase C alpha type [rat-ipi-250309-contam.fasta] Protein kinase C alpha type OS=Rattus norvegicus GN=Prkca [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	672 amino acids
Gene Ontology:
Cellular Component:	membrane fraction [UNKNOWN][IDA] nucleus [UNKNOWN][IEA] synaptosome [IDA] cytoplasm [UNKNOWN][IEA] mitochondrion [UNKNOWN][IDA] membrane raft [IDA] cytosol [UNKNOWN][IDA] protein complex [IDA] plasma membrane [UNKNOWN][IDA]
Biological Process:	central nervous system neuron axonogenesis [IMP] negative regulation of cell proliferation [UNKNOWN][IEA] chondrocyte differentiation [UNKNOWN][IEA] response to antibiotic [IEP] regulation of receptor-mediated endocytosis [IMP] protein amino acid phosphorylation [UNKNOWN][IEA] negative regulation of protein kinase activity [UNKNOWN][IEA] response to toxin [IEP] learning or memory [IMP] response to mechanical stimulus [IEP] negative regulation of heart contraction [IMP] positive regulation of exocytosis [IMP] inactivation of MAPK activity [UNKNOWN][IEA] positive regulation of smooth muscle cell proliferation [IMP] response to ethanol [IMP] regulation of peptidyl-tyrosine phosphorylation [UNKNOWN][IEA] regulation of muscle contraction [UNKNOWN][IEA] positive regulation of synaptogenesis [IMP] negative regulation of translation [IMP] induction of positive chemotaxis [UNKNOWN][IEA] positive regulation of inflammatory response [UNKNOWN][IEA] negative regulation of glucose import [UNKNOWN][IEA] response to organic cyclic substance [IEP] response to reactive oxygen species [IMP] aging [IEP] response to peptide hormone stimulus [IEP] negative regulation of insulin receptor signaling pathway [UNKNOWN][IEA] cellular calcium ion homeostasis [UNKNOWN][IEA] regulation of the force of heart contraction [UNKNOWN][IEA] induction of apoptosis by intracellular signals [UNKNOWN][IEA] establishment of protein localization [TAS] response to corticosterone stimulus [IEP] intracellular signaling pathway [IDA] histone H3-T6 phosphorylation [UNKNOWN] negative regulation of protein amino acid phosphorylation [UNKNOWN][IEA] positive regulation of protein amino acid phosphorylation [UNKNOWN][IEA] response to estradiol stimulus [IMP] response to interleukin-1 [UNKNOWN][IEA] neutrophil chemotaxis [UNKNOWN][IEA] peptidyl-serine phosphorylation [IDA] peptidyl-threonine phosphorylation [IDA]
Molecular Function:	nucleotide binding [IEA] ATP binding [IEA] zinc ion binding [IEA] protein binding [UNKNOWN][IPI] metal ion binding [IEA] protein serine/threonine kinase activity [UNKNOWN] transferase activity [IEA] calcium-dependent protein kinase C activity [UNKNOWN][IDA] protein kinase C activity [UNKNOWN][IDA][IEA] histone kinase activity (H3-T6 specific) [UNKNOWN]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADVYPANDS TASQDVANRF ARKGALRQKN VHEVKDHKFI ARFFKQPTFC SHCTDFIWGF  60
   61 GKQGFQCQVC CFVVHKRCHE FVTFSCPGAD KGPDTDDPRS KHKFKIHTYG SPTFCDHCGS 120
  121 LLYGLIHQGM KCDTCDMNVH KQCVINVPSL CGMDHTEKRG RIYLKAEVTD EKLHVTVRDA 180
  181 KNLIPMDPNG LSDPYVKLKL IPDPKNESKQ KTKTIRSTLN PQWNESFTFK LKPSDKDRRL 240
  241 SVEIWDWDRT TRNDFMGSLS FGVSELMKMP ASGWYKLLNQ EEGEYYNVPI PEGDEEGNVE 300
  301 LRQKFEKAKL GPAGNKVISP SEDRKQPSNN LDRVKLTDFN FLMVLGKGSF GKVMLADRKG 360
  361 TEELYAIKIL KKDVVIQDDD VECTMVEKRV LALLDKPPFL TQLHSCFQTV DRLYFVMEYV 420
  421 NGGDLMYHIQ QVGKFKEPQA VFYAAEISIG LFFLHKRGII YRDLKLDNVM LDSEGHIKIA 480
  481 DFGMCKEHMM DGVTTRTFCG TPDYIAPEII AYQPYGKSVD WWAYGVLLYE MLAGQPPFDG 540
  541 EDEDELFQSI MEHNVSYPKS LSKEAVSICK GLMTKHPAKR LGCGPEGERD VREHAFFRRI 600
  601 DWEKLENREI QPPFKPKVCG KGAENFDKFF TRGQPVLTPP DQLVIANIDQ SDFEGFSYVN 660
  661 PQFVHPILQS AV

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.97

Protein Overview: KPCA_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: