Protein Overview: PAK1_RAT

General Information:
Name(s) found:	PAK1_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|8393901\|ref\|NP_058894.1\| p21-activated kinase 1 [Rattus norvegicus] [NCBI NR] gi\|3915789\|sp\|P35465.3\|PAK1_RAT RecName: Full=Serine/threonine-protein kinase PAK 1; AltName: Full=p21-activated kinase 1; Short=PAK-1; AltName: Full=p68-PAK; AltName: Full=Alpha-PAK; AltName: Full=Protein kinase MUK2 [NCBI NR] gi\|2772514\|gb\|AAB95646.1\| serine/threonine protein kinase [Rattus norvegicus] [NCBI NR] gi\|149068910\|gb\|EDM18462.1\| p21 (CDKN1A)-activated kinase 1, isoform CRA_a [Rattus norvegicus] [NCBI NR] gi\|149068909\|gb\|EDM18461.1\| p21 (CDKN1A)-activated kinase 1, isoform CRA_a [Rattus norvegicus] [NCBI NR] gi\|149068908\|gb\|EDM18460.1\| p21 (CDKN1A)-activated kinase 1, isoform CRA_a [Rattus norvegicus] [NCBI NR] gi\|149068907\|gb\|EDM18459.1\| p21 (CDKN1A)-activated kinase 1, isoform CRA_a [Rattus norvegicus] [NCBI NR] gi\|149068906\|gb\|EDM18458.1\| p21 (CDKN1A)-activated kinase 1, isoform CRA_a [Rattus norvegicus] [NCBI NR] gi\|1399508\|gb\|AAB61533.1\| protein kinase MUK2 [Rattus norvegicus] [NCBI NR] Serine/threonine-protein kinase PAK 1 OS=Rattus norvegicus GN=Pak1 PE=1 SV=3 [Swiss-Prot] Ensembl_locations(Chr-bp):1-152510981 Serine/threonine-protein kinase PAK 1 [hmr_yeast5_DM3-1_pombe.fasta] p21 (CDKN1A)-activated kinase 1; p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related) [HMR_022704-rand.fasta] p21 (CDKN1A)-activated kinase 1 [Rattus norvegicus]gi\|2772514\|gb\|AAB95646.1\| serine/threonine protein kinase [Rattus norvegicus]gi\|1399508\|gb\|AAB61533.1\| protein kinase MUK2 [Rattus norvegicus]gi\|3915789\|sp\|P35465\|PAK1_RAT Serine/threonine-protein kina [nrdb_11152004_Chlamydomonas] Tax_Id=10116 Serine/threonine-protein kinase PAK 1 [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] (NM_017198) p21 (CDKN1A)-activated kinase 1 [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] p21 (CDKN1A)-activated kinase 1 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Serine/threonine-protein kinase PAK 1 (p21-activated kinase 1) (PAK-1) (p68-PAK) (Alpha-PAK) (Protein kinase MUK2) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] p21 (CDKN1A)-activated kinase 1, isoform CRA_a [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] serine/threonine protein kinase [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] protein kinase MUK2 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 SERINE/THREONINE-PROTEIN KINASE PAK 1 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Serine/threonine-protein kinase PAK 1 (p21-activated kinase 1) (PAK-1) (P68-PAK) (Alpha-PAK) (Protein kinase MUK2) [nr-271106-contam.fasta] Tax_Id=10116 Gene_Symbol=Pak1 Serine/threonine-protein kinase PAK 1 [rat-ipi-250309-contam.fasta] p21-activated kinase 1 [Rattus norvegicus] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta] Serine/threonine-protein kinase PAK 1 OS=Rattus norvegicus GN=Pak1 [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	544 amino acids
Gene Ontology:
Cellular Component:	membrane fraction [IDA] growth cone [UNKNOWN][IEA] nucleus [UNKNOWN][IEA] Z disc [IDA] dendrite [IDA] nuclear membrane [IDA] cytoplasm [UNKNOWN][ISS] cytosol [UNKNOWN][IDA] intercalated disc [IDA] Golgi apparatus [UNKNOWN] plasma membrane [UNKNOWN][IDA][ISS] axon [UNKNOWN][IDA]
Biological Process:	response to organic substance [IDA] positive regulation of JUN kinase activity [UNKNOWN][ISS] small GTPase mediated signal transduction [TAS] neuron projection morphogenesis [IMP] protein amino acid autophosphorylation [UNKNOWN][IDA][ISS] intracellular protein kinase cascade [TAS] receptor clustering [UNKNOWN][IEA] protein amino acid phosphorylation [UNKNOWN][IMP][ISS][TAS] neuromuscular junction development [UNKNOWN][IEA] cellular response to insulin stimulus [IDA] [NOT]MAPKKK cascade [UNKNOWN] response to hypoxia [IDA] regulation of actin cytoskeleton organization [IMP] cellular response to stress [IDA] dendrite development [UNKNOWN][IEA]
Molecular Function:	nucleotide binding [IEA] ATP binding [IEA] protein kinase binding [IPI] protein binding [UNKNOWN][IPI] collagen binding [UNKNOWN] protein kinase activity [UNKNOWN][IDA][ISS] MAP kinase kinase kinase activity [TAS] protein serine/threonine kinase activity [IDA][TAS] transferase activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNNGLDVQD KPPAPPMRNT STMIGAGSKD PGTLNHGSKP LPPNPEEKKK KDRFYRSILA  60
   61 GDKTNKKKEK ERPEISLPSD FEHTIHVGFD AVTGEFTGMP EQWARLLQTS NITKSEQKKN 120
  121 PQAVLDVLEF YNSKKTSNSQ KYMSFTDKSA EDYNSSNTLN VKTVSETPAV PPVSEDEDDD 180
  181 DDATPPPVIA PRPEHTKSVY TRSVIEPLPV TPTRDVATSP ISPTENNTTP PDALTRNTEK 240
  241 QKKKPKMSDE EILEKLRSIV SVGDPKKKYT RFEKIGQGAS GTVYTAMDVA TGQEVAIKQM 300
  301 NLQQQPKKEL IINEILVMRE NKNPNIVNYL DSYLVGDELW VVMEYLAGGS LTDVVTETCM 360
  361 DEGQIAAVCR ECLQALEFLH SNQVIHRDIK SDNILLGMDG SVKLTDFGFC AQITPEQSKR 420
  421 STMVGTPYWM APEVVTRKAY GPKVDIWSLG IMAIEMIEGE PPYLNENPLR ALYLIATNGT 480
  481 PELQNPEKLS AIFRDFLNRC LEMDVEKRGS AKELLQHQFL KIAKPLSSLT PLIAAAKEAT 540
  541 KNNH

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: PAK1_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: