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A cell-cell junction that contains the transmembrane protein N-cadherin, which interacts with identical molecules from neighboring cells to form a tight mechanical intercellular link; forms a large portion of the intercalated disc, the structure at which myofibrils terminate in cardiomyocytes. A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells. A cell junction that forms a connection between two cells; excludes direct cytoplasmic junctions such as ring canals. Extended zone of intimate apposition between two cells containing one or more types of intercellular junctions, e.g., the intercalated disk of muscle.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: intercalated disc
Acc: GO:0014704
Aspect: Cellular Component
Desc: A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells.
Synonyms:
  • intercalated disk
Proteins in PDR annotated with:
   This term: 24 [Search]
   Term or descendants: 40 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0014704 - intercalated disc (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle