Protein Overview: PAR1_RAT

General Information:
Name(s) found:	PAR1_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	ref\|NP_037082.1\| coagulation factor II receptor [Rattus norvegicus] [NCBI NR] pir\|\|A43448 thrombin receptor - rat [NCBI NR] gi\|207466\|gb\|AAA42274.1\| thrombin receptor [NCBI NR] gi\|135818\|sp\|P26824.1\|PAR1_RAT RecName: Full=Proteinase-activated receptor 1; Short=PAR-1; AltName: Full=Thrombin receptor; Flags: Precursor [NCBI NR] Proteinase-activated receptor 1 OS=Rattus norvegicus GN=F2r PE=2 SV=1 [Swiss-Prot] Ensembl_locations(Chr-bp):2-24050960 Proteinase activated receptor 1 precursor [hmr_yeast5_DM3-1_pombe.fasta] coagulation factor II receptor; Thrombin receptor; protease-activated receptor 1; Coagulation factor II (thrombin) receptor [HMR_022704-rand.fasta] coagulation factor II receptor [Rattus norvegicus]gi\|285442\|pir\|\|A43448 thrombin receptor - ratgi\|135818\|sp\|P26824\|PAR1_RAT Proteinase activated receptor 1 precursor (PAR-1) (Thrombin receptor)gi\|207466\|gb\|AAA42274.1\| thrombin receptor [nrdb_11152004_Chlamydomonas] Tax_Id=10116 Proteinase-activated receptor 1 precursor [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] (NM_012950) Coagulation factor II (thrombin) receptor; Thrombin receptor; protease-activated receptor 1 [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] Tax_Id=10116 Proteinase activated receptor 1 precursor [EBI-IPI_rat_3.08_07-12-2005_origrev_con.fasta] Proteinase-activated receptor 1 precursor (PAR-1) (Thrombin receptor) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] thrombin receptor [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 PROTEINASE ACTIVATED RECEPTOR 1 PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Tax_Id=10116 Gene_Symbol=F2r Proteinase-activated receptor 1 [rat-ipi-250309-contam.fasta] Proteinase-activated receptor 1 OS=Rattus norvegicus GN=F2r [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	432 amino acids
Gene Ontology:
Cellular Component:	platelet dense tubular network [UNKNOWN][IEA] caveola [UNKNOWN][IEA] postsynaptic membrane [IDA] integral to membrane [IEA] neuromuscular junction [IDA] plasma membrane [UNKNOWN][IDA]
Biological Process:	positive regulation of phosphoinositide 3-kinase cascade [UNKNOWN] positive regulation of blood coagulation [UNKNOWN][IEA] regulation of blood coagulation [UNKNOWN] negative regulation of cell proliferation [UNKNOWN][IEA] positive regulation of cell proliferation [IDA] positive regulation of vasoconstriction [IDA] positive regulation of calcium ion transport [IMP] response to wounding [UNKNOWN] positive regulation of I-kappaB kinase/NF-kappaB cascade [UNKNOWN][IEA] blood coagulation [TAS] negative regulation of neuron apoptosis [IMP] positive regulation of smooth muscle contraction [IDA] establishment of synaptic specificity at neuromuscular junction [IDA] activation of MAPKK activity [IMP] inflammatory response [UNKNOWN][IEA] positive regulation of collagen biosynthetic process [UNKNOWN][IEA] positive regulation of transcription, DNA-dependent [UNKNOWN][IEA] elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger [IMP] activation of caspase activity [UNKNOWN][IEA] release of sequestered calcium ion into cytosol [UNKNOWN][IMP] platelet activation [UNKNOWN][IEA] tyrosine phosphorylation of STAT protein [UNKNOWN][IEA] G-protein coupled receptor protein signaling pathway [IDA] signal transduction [IEA] STAT protein nuclear translocation [UNKNOWN][IEA] positive regulation of MAPKKK cascade [UNKNOWN][IEA] activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway [IMP] positive regulation of JAK-STAT cascade [UNKNOWN][IEA] positive regulation of caspase activity [UNKNOWN] thrombin receptor signaling pathway [UNKNOWN] connective tissue replacement during inflammatory response [UNKNOWN][IEA] homeostasis of number of cells within a tissue [UNKNOWN][IEA] death [UNKNOWN][IEA] response to lipopolysaccharide [UNKNOWN][IEA] regulation of interleukin-1 beta production [UNKNOWN][IEA] regulation of sensory perception of pain [IDA] positive regulation of cell migration [UNKNOWN][IEA]
Molecular Function:	G-protein coupled receptor activity [UNKNOWN][IEA] protein binding [UNKNOWN] thrombin receptor activity [UNKNOWN][TAS] receptor activity [IEA] receptor binding [UNKNOWN][IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGPRRLLLVA VGLSLCGPLL SSRVPMRQPE SERMYATPYA TPNPRSFFLR NPSEDTFEQF  60
   61 PLGDEEEKNE SIPLEGRAVY LNKSRFPPMP PPPFISEDAS GYLTSPWLTL FIPSVYTFVF 120
  121 IVSLPLNILA IAVFVFRMKV KKPAVVYMLH LAMADVLFVS VLPFKISYYF SGTDWQFGSG 180
  181 MCRFATAACY CNMYASIMLM TVISIDRFLA VVYPIQSLSW RTLGRANFTC VVIWVMAIMG 240
  241 VVPLLLKEQT TQVPGLNITT CHDVLNETLL HGFYSYYFSA FSAIFFLVPL IISTVCYTSI 300
  301 IRCLSSSAVA NRSKKSRALF LSAAVFCIFI VCFGPTNVLL IVHYLLLSDS PGTETAYFAY 360
  361 LLCVCVTSVA SCIDPLIYYY ASSECQKHLY SILCCRESSD SNSCNSTGQL MPSKMDTCSS 420
  421 HLNNSIYKKL LA

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: PAR1_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: