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Any process that modulates the rate, frequency or extent of a series of reactions, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound. Any process that increases the rate, frequency or extent of a series of reactions, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound. Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein. Any process that activates or increases the frequency, rate or extent of a signaling pathway. Any process that modulates the frequency, rate or extent of the JAK-STAT signaling pathway. Any process by which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of cytokines to their cognate receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes. A series of reactions that occur within the cell, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound. Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: positive regulation of JAK-STAT cascade
Acc: GO:0046427
Aspect: Biological Process
Desc: Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity.
Synonyms:
  • activation of JAK-STAT cascade
  • up regulation of JAK-STAT cascade
  • up-regulation of JAK-STAT cascade
  • stimulation of JAK-STAT cascade
  • upregulation of JAK-STAT cascade
Proteins in PDR annotated with:
   This term: 24 [Search]
   Term or descendants: 54 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0046427 - positive regulation of JAK-STAT cascade (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle