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Protein Overview: MK08_RAT

General Information:
Name(s) found: MK08_RAT [Swiss-Prot]
Description(s) found:
Found 14 descriptions.
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  • Mitogen-activated protein kinase 8 OS=Rattus norvegicus GN=Mapk8 PE=1 SV=1 [Swiss-Prot]
    • Organism: Rattus norvegicus
    Length: 411 amino acids

    Gene Ontology:
    Cellular Component: nucleus [UNKNOWN][IDA]
    cytoplasm [UNKNOWN][IDA]
    mitochondrion [IDA]
    dendrite cytoplasm [IDA]
    cytosol [UNKNOWN]
    vesicle [IDA]
    axon part [IDA]
    perikaryon [IDA]
    nucleoplasm [UNKNOWN]
    Biological Process: signal transduction [IDA]
    neuron projection development [IMP]
    response to osmotic stress [IDA]
    regulation of transcription, DNA-dependent [IDA]
    JNK cascade [UNKNOWN][ISS]
    response to UV [UNKNOWN]
    positive regulation of DNA replication [IMP]
    response to cadmium ion [UNKNOWN]
    response to hydrogen peroxide [IDA]
    response to steroid hormone stimulus [IEP]
    protein amino acid phosphorylation [UNKNOWN][IEA]
    induction of apoptosis by extracellular signals [UNKNOWN]
    JUN phosphorylation [UNKNOWN]
    activation of pro-apoptotic gene products [UNKNOWN]
    inflammatory response [IDA]
    response to heat [IDA]
    induction of apoptosis in response to chemical stimulus [UNKNOWN]
    ossification [UNKNOWN]
    negative regulation of apoptosis [IDA]
    apoptosis [UNKNOWN]
    positive regulation of apoptosis [IEP]
    positive regulation of microtubule polymerization [IMP]
    peptidyl-threonine phosphorylation [UNKNOWN]
    positive regulation of cell migration [IDA]
    Molecular Function: nucleotide binding [IEA]
    ATP binding [IEA]
    protein binding [UNKNOWN][IPI]
    JUN kinase activity [UNKNOWN][IDA][ISS][TAS]
    MAP kinase activity [IEA]
    protein serine/threonine kinase activity [UNKNOWN][IEA]
    transferase activity [IEA]
    kinase activity [UNKNOWN]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRSKRDNNF YSVEIADSTF TVLKRYQNLK PIGSGAQGIV CAAYDAILER NVAIKKLSRP  60
   61 FQNQTHAKRA YRELVLMKCV NHKNIIGLLN VFTPQKSLEE FQDVYIVMEL MDANLCQVIQ 120
  121 MELDHERMSY LLYQMLCGIK HLHSAGIIHR DLKPSNIVVK SDCTLKILDF GLARTAGTSF 180
  181 MMTPYVVTRY YRAPEVILGM GYKENVDLWS VGCIMGEMVC LKILFPGRDY IDQWNKVIEQ 240
  241 LGTPCPEFMK KLQPTVRTYV ENRPKYAGYS FEKLFPDVLF PADSEHNKLK ASQARDLLSK 300
  301 MLVIDASKRI SVDEALQHPY INVWYDPSEA EAPPPKIPDK QLDEREHTIE EWKELIYKEV 360
  361 MDLEERTKNG VIRGQPSPLG AAVINGSQHP VSSPSVNDMS SMSTDPTLAS D

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle