Protein Overview: ATP7A_RAT

General Information:
Name(s) found:	ATP7A_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|16258817\|ref\|NP_434690.1\| ATPase, Cu++ transporting, alpha polypeptide [Rattus norvegicus] [NCBI NR] gi\|1498322\|gb\|AAB06393.1\| Menkes protein [Rattus norvegicus] [NCBI NR] gi\|149055556\|gb\|EDM07140.1\| ATPase, Cu++ transporting, alpha polypeptide, isoform CRA_b [Rattus norvegicus] [NCBI NR] gi\|12229551\|sp\|P70705.1\|ATP7A_RAT RecName: Full=Copper-transporting ATPase 1; AltName: Full=Copper pump 1; AltName: Full=Menkes disease-associated protein homolog [NCBI NR] Copper-transporting ATPase 1 OS=Rattus norvegicus GN=Atp7a PE=1 SV=1 [Swiss-Prot] (P70705) Copper-transporting ATPase 1 (EC 3.6.3.4) (Copper pump 1) (Menkes disease-associated protein homolog) [Swiss-Prot] Ensembl_locations(Chr-bp):X-24609396 Copper-transporting ATPase 1 [hmr_yeast5_DM3-1_pombe.fasta] ATPase, Cu++ transporting, alpha polypeptide; ATPase, Cu++ transporting, alpha polypeptide (Menkes syndrome); ATPase Cu++ transporting alpha polypeptide (Menkes syndrome) [HMR_022704-rand.fasta] ATPase, Cu++ transporting, alpha polypeptide [Rattus norvegicus]gi\|1498322\|gb\|AAB06393.1\| Menkes protein [Rattus norvegicus]gi\|12229551\|sp\|P70705\|AT7A_RAT Copper-transporting ATPase 1 (Copper pump 1) (Menkes disease-associated protein homolog) [nrdb_11152004_Chlamydomonas] Tax_Id=10116 Copper-transporting ATPase 1 [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] (NM_052803) ATPase, Cu++ transporting, alpha polypeptide (Menkes syndrome) [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] Copper-transporting ATPase 1 (Copper pump 1) (Menkes disease-associated protein homolog) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] ATPase, Cu++ transporting, alpha polypeptide [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] ATPase, Cu++ transporting, alpha polypeptide, isoform CRA_b [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Menkes protein [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 COPPER-TRANSPORTING ATPASE 1 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Tax_Id=10116 Gene_Symbol=Atp7a Copper-transporting ATPase 1 [rat-ipi-250309-contam.fasta] Copper-transporting ATPase 1 OS=Rattus norvegicus GN=Atp7a [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	1492 amino acids
Gene Ontology:
Cellular Component:	secretory granule [IDA] trans-Golgi network transport vesicle [UNKNOWN] late endosome [UNKNOWN] endoplasmic reticulum [UNKNOWN] Golgi apparatus [UNKNOWN][IDA] neuronal cell body [UNKNOWN][IEA] neuron projection [UNKNOWN][IEA] plasma membrane [UNKNOWN][IEA] integral to membrane of membrane fraction [IDA] membrane fraction [UNKNOWN] trans-Golgi network [UNKNOWN][IDA] brush border membrane [IDA] perinuclear region of cytoplasm [UNKNOWN][IDA] membrane [UNKNOWN] integral to membrane [IEA] cytoplasmic vesicle [UNKNOWN][IEA] basolateral plasma membrane [UNKNOWN][IDA]
Biological Process:	norepinephrine metabolic process [UNKNOWN] dopamine metabolic process [UNKNOWN][IEA] copper ion export [UNKNOWN][IEA] regulation of oxidative phosphorylation [UNKNOWN][IEA] central nervous system neuron development [UNKNOWN][IEA] tryptophan metabolic process [UNKNOWN][IEA] skin development [UNKNOWN][IEA] epinephrine metabolic process [UNKNOWN][IEA] lung alveolus development [UNKNOWN][IEA] cellular copper ion homeostasis [UNKNOWN][IEA] in utero embryonic development [IEP] pigmentation [UNKNOWN][IEA] detoxification of copper ion [UNKNOWN][IEA] serotonin metabolic process [UNKNOWN][IEA] tyrosine metabolic process [UNKNOWN][IEA] cerebellar Purkinje cell differentiation [UNKNOWN][IEA] metabolic process [IEA] norepinephrine biosynthetic process [UNKNOWN][IEA] pyramidal neuron development [UNKNOWN][IEA] elastic fiber assembly [UNKNOWN][IEA] positive regulation of catalytic activity [UNKNOWN] removal of superoxide radicals [UNKNOWN][IEA] ATP metabolic process [UNKNOWN] release of cytochrome c from mitochondria [UNKNOWN][IEA] regulation of gene expression [UNKNOWN][IEA] hair follicle morphogenesis [UNKNOWN][IEA] copper ion import [UNKNOWN][IEA] cartilage development [UNKNOWN][IEA] response to iron(III) ion [IEP] neuroprotection [UNKNOWN][IEA] response to zinc ion [IEP] neuron projection morphogenesis [UNKNOWN] lactation [IEP] catecholamine metabolic process [UNKNOWN] dendrite morphogenesis [UNKNOWN][IEA] ion transport [IEA] locomotory behavior [UNKNOWN][IEA] elastin biosynthetic process [UNKNOWN][IEA] blood vessel development [UNKNOWN][IEA] metal ion transport [IEA] hindlimb morphogenesis [UNKNOWN] response to copper ion [IDA] ATP biosynthetic process [IEA] mitochondrion organization [UNKNOWN][IEA] copper ion transport [UNKNOWN][IEA] T-helper cell differentiation [UNKNOWN][IEA] blood vessel remodeling [UNKNOWN][IEA] positive regulation of metalloenzyme activity [UNKNOWN][IEA] positive regulation of oxidoreductase activity [UNKNOWN] negative regulation of metalloenzyme activity [UNKNOWN][IEA] extracellular matrix organization [UNKNOWN] collagen fibril organization [UNKNOWN][IEA] peptidyl-lysine modification [UNKNOWN][IEA]
Molecular Function:	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism [IEA] metal ion transmembrane transporter activity [IEA] copper ion transmembrane transporter activity [UNKNOWN][IEA] molecular_function [ND] nucleotide binding [IEA] ATP binding [IEA] copper-exporting ATPase activity [UNKNOWN][IEA] protein binding [UNKNOWN][IEA] copper ion binding [UNKNOWN][IEA] metal ion binding [IEA] superoxide dismutase copper chaperone activity [UNKNOWN][IEA] copper-dependent protein binding [UNKNOWN] hydrolase activity [IEA] hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
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    1 MEPNMDANSI TITVEGMTCI SCVRTIEQQI GKVNGVHHIK VSLEEKSATV IYNPKLQTPK  60
   61 TLQEAIDDMG FDALLHNANP LPVLTNTVFL TVTAPLALPW DHIQSTLLKT KGVTGVKISP 120
  121 QQRSAVVTII PSVVSANQIV ELVPDLSLDM GTQEKKSGTS EEHSTPQAGE VLLKMRVEGM 180
  181 TCHSCTSTIE GKVGKLQGVQ RIKVSLDNQE ATIVYQPHLI TAEEIKKQIE AVGFPAFIKK 240
  241 QPKYLKLGAI DVERLKSTPV KSSEGSQQKS PAYPSDSAIT FTIDGMHCKS CVSNIESALS 300
  301 TLQYVSSIVV SLENRSAIVK YNASLVTPEI LRKAIEAVSP GQYRVSISSE VESPTSSPSS 360
  361 SSLQKMPLNL VSQPLTQEVV ININGMTCNS CVQSIEGVIS KKPGVKSIHV SLTNSTGTIE 420
  421 YDPLLTSPEP LREAIEDMGF DAVLPADMKE PLVVIAQPSL ETPLLPSTTE PENVMTPVQN 480
  481 KCYIQVSGMT CASCVANIER NLRREEGIYS VLVALMAGKA EVRYNPAVIQ PRVIAELIRE 540
  541 LGFGAVVMEN AGEGNGILEL VVRGMTCASC VHKIESTLTK HKGIFYCSVA LATNKAHIKY 600
  601 DPEIIGPRDI IHTIGNLGFE ASLVKKDRSA NHLDHKREIK QWRGSFLVSL FFCIPVMGLM 660
  661 IYMMVMDHHL ATLNHNQNMS NEEMINMHSS MFLERQILPG LSIMNLLSLL LCLPVQFCGG 720
  721 WYFYIQAYKA LRHKTANMDV LIVLATTIAF AYSLVILLVA MYERAKVNPI TFFDTPPMLF 780
  781 VFIALGRWLE HIAKGKTSEA LAKLISLQAT EATIVTLNSE NLLLSEEQVD VELVQRGDII 840
  841 KVVPGGKFPV DGRVIEGHSM VDESLITGEA MPVAKKPGST VIAGSINQNG SLLIRATHVG 900
  901 ADTTLSQIVK LVEEAQTSKA PIQQFADKLS GYFVPFIVLV SIVTLLVWII IGFQNFEIVE 960
  961 AYFPGYNRSI SRTETIIRFA FQASITVLCI ACPCSLGLAT PTAVMVGTGV GAQNGILIKG1020
 1021 GEPLEMAHKV KVVVFDKTGT ITHGTPVVNQ VKVLVESNKI SRNKILAIVG TAESNSEHPL1080
 1081 GAAVTKYCKQ ELDTETLGTC TDFQVVPGCG ISCKVTNIEG LLHKSNLKIE ENNIKNASLV1140
 1141 QIDAINEQSS PSSSMIIDAH LSNAVNTQQY KVLIGNREWM IRNGLVISND VDESMIEHER1200
 1201 RGRTAVLVTI DDELCGLIAI ADTVKPEAEL AVHILKSMGL EVVLMTGDNS KTARSIASQV1260
 1261 GITKVFAEVL PSHKVAKVKQ LQEEGKRVAM VGDGINDSPA LAMASVGIAI GTGTDVAIEA1320
 1321 ADVVLIRNDL LDVVASIDLS RKTVKRIRIN FVFALIYNLI GIPIAAGVFL PIGLVLQPWM1380
 1381 GSAAMAASSV SVVLSSLFLK LYRKPTYDNY ELRPRSHTGQ RSPSEISVHV GIDDTSRNSP1440
 1441 RLGLLDRIVN YSRASINSLL SDKRSLNSVV TSEPDKHSLL VGDFREDDDT TL

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: ATP7A_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: