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The process whereby a relatively unspecialized thymocyte acquires specialized features of a T-helper cell. The process whereby a relatively unspecialized T cell acquires the specialized features of a Th1 cell. The process whereby a relatively unspecialized T cell acquires specialized features of a Th2 cell. The process whereby an antigenically nave alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell during an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells. The process whereby a relatively unspecialized T cell acquires specialized features of a mature CD4-positive, alpha-beta T cell. The process whereby an antigenically nave CD4-positive, alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell during an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells. Any process that activates or increases the frequency, rate or extent of T-helper cell differentiation. The process whereby a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper cell, a CD4-positive, alpha-beta T cell specialized to promote various immunological processes. Any process that stops, prevents or reduces the frequency, rate or extent of T-helper cell differentiation. Any process that modulates the frequency, rate or extent of T-helper cell differentiation.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: T-helper cell differentiation
Acc: GO:0042093
Aspect: Biological Process
Desc: The process whereby a relatively unspecialized thymocyte acquires specialized features of a T-helper cell.
Proteins in PDR annotated with:
   This term: 5 [Search]
   Term or descendants: 20 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0042093 - T-helper cell differentiation (interactive image map)
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