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Protein Overview: APOE_RAT

General Information:
Name(s) found: APOE_RAT [Swiss-Prot]
Description(s) found:
Found 22 descriptions.
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  • Apolipoprotein E OS=Rattus norvegicus GN=Apoe PE=1 SV=2 [Swiss-Prot]
    • Organism: Rattus norvegicus
    Length: 312 amino acids

    Gene Ontology:
    Cellular Component: very-low-density lipoprotein particle [UNKNOWN]
    chylomicron [UNKNOWN]
    high-density lipoprotein particle [UNKNOWN]
    intermediate-density lipoprotein particle [UNKNOWN]
    low-density lipoprotein particle [UNKNOWN]
    late endosome [IDA]
    Golgi apparatus [IDA]
    neuronal cell body [IDA]
    extracellular region [UNKNOWN]
    plasma membrane [UNKNOWN]
    microtubule [IDA]
    dendrite [IDA]
    extracellular space [UNKNOWN][IDA]
    early endosome [IDA]
    cytoplasm [IDA]
    extrinsic to external side of plasma membrane [IDA]
    Biological Process: negative regulation of blood coagulation [UNKNOWN]
    [NOT]protein localization [UNKNOWN]
    triglyceride metabolic process [UNKNOWN]
    anti-apoptosis [UNKNOWN]
    positive regulation of nitric-oxide synthase activity [UNKNOWN]
    positive regulation of membrane protein ectodomain proteolysis [UNKNOWN]
    induction of apoptosis [UNKNOWN]
    positive regulation of cGMP biosynthetic process [UNKNOWN]
    positive regulation of low-density lipoprotein receptor catabolic process [UNKNOWN]
    Cdc42 protein signal transduction [UNKNOWN]
    chylomicron remnant clearance [UNKNOWN]
    high-density lipoprotein particle assembly [UNKNOWN]
    G-protein coupled receptor protein signaling pathway [UNKNOWN]
    nitric oxide mediated signal transduction [UNKNOWN]
    high-density lipoprotein particle clearance [UNKNOWN]
    artery morphogenesis [UNKNOWN]
    receptor-mediated endocytosis [UNKNOWN]
    maintenance of location in cell [UNKNOWN]
    negative regulation of cholesterol biosynthetic process [UNKNOWN]
    cellular response to growth factor stimulus [IEP]
    regulation of gene expression [UNKNOWN]
    negative regulation of platelet activation [UNKNOWN]
    neuron projection regeneration [TAS]
    [NOT]axon regeneration [UNKNOWN]
    very-low-density lipoprotein particle remodeling [UNKNOWN]
    cGMP-mediated signaling [UNKNOWN]
    negative regulation of MAP kinase activity [UNKNOWN]
    high-density lipoprotein particle remodeling [UNKNOWN]
    cholesterol metabolic process [UNKNOWN]
    response to dietary excess [UNKNOWN]
    lipoprotein metabolic process [UNKNOWN][IDA]
    vasodilation [UNKNOWN]
    lipoprotein biosynthetic process [UNKNOWN]
    lipoprotein catabolic process [UNKNOWN]
    cholesterol homeostasis [UNKNOWN]
    response to oxidative stress [UNKNOWN]
    response to ethanol [IDA]
    reverse cholesterol transport [UNKNOWN]
    positive regulation of cholesterol efflux [UNKNOWN]
    positive regulation of cholesterol esterification [UNKNOWN]
    very-low-density lipoprotein particle clearance [UNKNOWN]
    negative regulation of blood vessel endothelial cell migration [UNKNOWN]
    axon regeneration in the peripheral nervous system [IEP]
    lipid homeostasis [UNKNOWN]
    aging [IDA]
    cellular calcium ion homeostasis [UNKNOWN]
    lipid transport [IDA]
    cholesterol catabolic process [UNKNOWN]
    lipid metabolic process [UNKNOWN]
    negative regulation of endothelial cell proliferation [UNKNOWN]
    cholesterol efflux [UNKNOWN]
    phospholipid efflux [UNKNOWN]
    Molecular Function: identical protein binding [UNKNOWN]
    protein homodimerization activity [UNKNOWN]
    lipoprotein binding [UNKNOWN]
    antioxidant activity [UNKNOWN]
    phosphatidylcholine-sterol O-acyltransferase activator activity [UNKNOWN]
    heparin binding [UNKNOWN]
    lipid binding [UNKNOWN]
    phospholipid binding [UNKNOWN][IDA]
    beta-amyloid binding [UNKNOWN]
    metal chelating activity [UNKNOWN]
    protein binding [UNKNOWN]
    low-density lipoprotein receptor binding [UNKNOWN]
    lipid transporter activity [UNKNOWN][IDA]
    protein heterodimerization activity [UNKNOWN]
    tau protein binding [UNKNOWN]
    cholesterol transporter activity [UNKNOWN]
    very-low-density lipoprotein receptor binding [UNKNOWN]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKALWALLLV PLLTGCLAEG ELEVTDQLPG QSDQPWEQAL NRFWDYLRWV QTLSDQVQEE  60
   61 LQSSQVTQEL TVLMEDTMTE VKAYKKELEE QLGPVAEETR ARLAKEVQAA QARLGADMED 120
  121 LRNRLGQYRN EVNTMLGQST EELRSRLSTH LRKMRKRLMR DADDLQKRLA VYKAGAQEGA 180
  181 ERGVSAIRER LGPLVEQGRQ RTANLGAGAA QPLRDRAQAL SDRIRGRLEE VGNQARDRLE 240
  241 EVREQMEEVR SKMEEQTQQI RLQAEIFQAR IKGWFEPLVE DMQRQWANLM EKIQASVATN 300
  301 SIASTTVPLE NQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle