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Protein Overview: gi|209863018, gi...

General Information:
Name(s) found: gi|209863018 [NCBI NR]
gi|171847215 [NCBI NR]
gi|149058117 [NCBI NR]
Description(s) found:
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  • gi|209863018|ref|NP_001094151.1| pre-B-cell leukemia homeobox 1 isoform b [Rattus norvegicus] [NCBI NR]
  • gi|171847215|gb|AAI61983.1| Pbx1 protein [Rattus norvegicus] [NCBI NR]
  • gi|149058117|gb|EDM09274.1| pre-B-cell leukemia transcription factor 1 (predicted), isoform CRA_a [Rattus norvegicus] [NCBI NR]
  • Tax_Id=10116 38 kDa protein [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta]
  • Pbx1 protein [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • pre-B-cell leukemia transcription factor 1 (predicted), isoform CRA_a [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • pre-B-cell leukemia homeobox 1 isoform b [Rattus norvegicus] [NCBI-RefSeq_human-rat_na_04-07-2009_con_reversed.fasta]
  • Tax_Id=10116 Gene_Symbol=Pbx1 Pbx1 protein [rat-ipi-250309-contam.fasta]
  • Pbx1 protein OS=Rattus norvegicus GN=Pbx1 [011711_HMR.fasta]
  • Pbx1 protein OS=Rattus norvegicus GN=Pbx1 PE=2 SV=1 [UNIPROT_RAT_07-21-2011_reversed.fasta]
    • Organism: Rattus norvegicus
    Length: 347 amino acids

    Gene Ontology:
    Cellular Component: nucleus [UNKNOWN][IEA]
    transcription factor complex [UNKNOWN]
    cytoplasm [UNKNOWN]
    [NOT]nucleolus [UNKNOWN]
    cellular_component [ND]
    Biological Process: biological_process [ND]
    embryonic hemopoiesis [UNKNOWN]
    positive regulation of cell proliferation [UNKNOWN]
    anterior/posterior pattern formation [UNKNOWN]
    negative regulation of neuron differentiation [UNKNOWN]
    regulation of transcription, DNA-dependent [IEA]
    spleen development [UNKNOWN]
    negative regulation of transcription factor activity [UNKNOWN]
    embryonic organ development [UNKNOWN]
    positive regulation of transcription from RNA polymerase II promoter [UNKNOWN]
    embryonic skeletal system development [UNKNOWN]
    proximal/distal pattern formation [UNKNOWN]
    regulation of cell proliferation [UNKNOWN]
    organ morphogenesis [UNKNOWN]
    thymus development [UNKNOWN]
    embryonic limb morphogenesis [UNKNOWN]
    urogenital system development [UNKNOWN]
    branching involved in ureteric bud morphogenesis [UNKNOWN]
    regulation of ossification [UNKNOWN]
    adrenal gland development [UNKNOWN]
    Molecular Function: DNA binding [UNKNOWN]
    transcription factor activity [IEA]
    protein binding [UNKNOWN]
    protein heterodimerization activity [UNKNOWN]
    sequence-specific DNA binding [UNKNOWN][IEA]
    transcription factor binding [UNKNOWN]
    molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDEQPRLMHS HAGVGMAGHP GLSQHLQDGA GGTEGEGGRK QDIGDILQQI MTITDQSLDE  60
   61 AQARKHALNC HRMKPALFNV LCEIKEKTVL SIRGAQEEEP TDPQLMRLDN MLLAEGVAGP 120
  121 EKGGGSAAAA AAAAASGGAG SDNSVEHSDY RAKLSQIRQI YHTELEKYEQ ACNEFTTHVM 180
  181 NLLREQSRTR PISPKEIERM VSIIHRKFSS IQMQLKQSTC EAVMILRSRF LDARRKRRNF 240
  241 NKQATEILNE YFYSHLSNPY PSEEAKEELA KKCGITVSQV SNWFGNKRIR YKKNIGKFQE 300
  301 EANIYAAKTA VTATNVSAHG SQANSPSTPN SAGGYPSPCY QPDRRIQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..93] deduced N/A No confident structure predictions are available.
    2 View Details [94..235] FFAS03 0.975 No description for 2h8rA was found.
    3 View Details [236..347] PSI-BLAST 21.522879 pbx1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • transcription regulator activity
    		•  5.13863038737912 bayes_pls_golite062009
  • DNA binding
    		•  4.66369707598026 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.51452285155271 bayes_pls_golite062009
  • transcription factor activity
    		•  4.06706589695599 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  3.5139760613123 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.16896789933192 bayes_pls_golite062009
  • transcription activator activity
    		•  3.10621734076555 bayes_pls_golite062009
  • binding
    		•  3.02779747447702 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.91962622287073 bayes_pls_golite062009
  • protein binding
    		•  1.88087411289001 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.73068440195944 bayes_pls_golite062009
  • chromatin binding
    		•  1.68956710349366 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.62096064323298 bayes_pls_golite062009
  • transcription factor binding
    		•  1.40653841901929 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.84983974758882 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.2679415219517 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.25931464844298 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle