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Protein Overview: Dscam-PAW

General Information:
Name(s) found: Dscam-PAW / FBpp0110363 [FlyBase]
Description(s) found:
Found 16 descriptions.
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  • The gene Down syndrome cell adhesion molecule is referred to in FlyBase by the symbol Dmel\Dscam (CG17800, FBgn0033159). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:3207059..3269374. It has the cytological map location 43A4-43B1. There is experimental evidence that it has the molecular function</span>: protein binding; bacterial binding; protein homodimerization activity; axon guidance receptor activity. There is experimental evidence that it is involved in the biological process</span>: dendrite self-avoidance; axon extension involved in axon guidance; axon guidance; phagocytosis; central nervous system morphogenesis; neuron development; axonal fasciculation; mushroom body development; peripheral nervous system development. 120 alleles are reported. The phenotypes of these alleles are annotated with 18 unique terms, many of which group under: nervous system; multi-cell-component structure; organ system; adult segment; embryonic nervous system; commissure; antennal segment; adult brain; peripheral nervous system; mushroom body. It has 59 annotated transcripts and 59 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 2034 amino acids

    Gene Ontology:
    Cellular Component: integral to plasma membrane [ISS]
    dendrite [IDA]
    neuronal cell body [IDA]
    axon [IDA]
    Biological Process: mushroom body development [IMP]
    dendrite self-avoidance [IDA][IMP]
    phagocytosis [IMP]
    axon guidance [IGI][IMP][TAS]
    peripheral nervous system development [IMP]
    neuron development [IMP]
    central nervous system morphogenesis [IMP]
    axonal fasciculation [IMP]
    axon extension involved in axon guidance [IMP]
    Molecular Function: protein binding [IDA]
    protein homodimerization activity [IPI]
    axon guidance receptor activity [IMP][NAS]
    bacterial cell surface binding [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNMPNERLKW LMLFAAVALI ACGSQTLAAN PPDADQKGPV FLKEPTNRID FSNSTGAEIE  60
   61 CKASGNPMPE IIWIRSDGTA VGDVPGLRQI SSDGKLVFPP FRAEDYRQEV HAQVYACLAR 120
  121 NQFGSIISRD VHVRAVVHQF YQTRVIDEFV LRGNSATLKC LVPSFVADFI DVEGWIDEEG 180
  181 VEILRPLPDD SVDGKYLVLP SGELHIREVG PEDGYKSYQC RTKHRLTGET RLSATKGRLV 240
  241 ITEPIGSKAP SVPTGVMVFQ QQVPLLSTFA MLCQAQAFPV PVFRWYKFIE GTTRKQAVVL 300
  301 NDRVKQVSGT LIIKDAVVED SGKYLCVVNN SVGGESVETV LTVTAPLSAK IDPPTQTVDF 360
  361 GRPAVFTCQY TGNPIKTVSW MKDGKAIGHS EPVLRIESVK KEDKGMYQCF VRNDQESAEA 420
  421 SAELKLGGRF DPPVIRQAFQ EETMEPGPSV FLKCVAGGNP TPEISWELDG KKIANNDRYQ 480
  481 VGQYVTVNGD VVSYLNITSV HANDGGLYKC IAKSKVGVAE HSAKLNVYGL PYIRQMEKKA 540
  541 IVAGETLIVT CPVAGYPIDS IVWERDNRAL PINRKQKVFP NGTLIIENVE RNSDQATYTC 600
  601 VAKNQEGYSA RGSLEVQVMV APKIASFDFG EEPLNYGEPA SVQCTILGGD LPMNVTWLLN 660
  661 NATIDSFHDI SFSRIGKRIN VLSIESVSAH HAGFYSCHAQ NKAGITAHSA RLIVNVPPRW 720
  721 ILEPTDKAFA QGSDAKVECK ADGFPKPQVT WKKAVGDTPG EYKDLKKSDN IRVEEGTLHV 780
  781 DNIQKTNEGY YLCEAINGIG SGLSAVIMIS VQAPPEFTEK LRNQTARRGE PAVLQCEAKG 840
  841 EKPIGILWNM NNMRLDPKND NRYTIREEIL STGVMSSLSI KRTERSDSAL FTCVATNAFG 900
  901 SDDASINMIV QEVPEMPYAL KVLDKSGRSV QLSWAQPYDG NSPLDRYIIE FKRSRASWSE 960
  961 IDRVIVPGHT TEAQVQKLSP ATTYNIRIVA ENAIGTSQSS EAVTIITAEE APSGKPQNIK1020
 1021 VEPVNQTTMR VTWKPPPRTE WNGEILGYYV GYKLSNTNSS YVFETINFIT EEGKEHNLEL1080
 1081 QNLRVYTQYS VVIQAFNKIG AGPLSEEEKQ FTAEGTPSQP PSDTACTTLT SQTIRVGWVS1140
 1141 PPLESANGVI KTYKVVYAPS DEWYDETKRH YKKTASSDTV LHGLKKYTNY TMQVLATTAG1200
 1201 GDGVRSVPIH CQTEPDVPEA PTDVKALVMG NAAILVSWRP PAQPNGIITQ YTVYSKAEGA1260
 1261 ETETKTQKVP HYQMSFEATE LEKNKPYEFW VTASTTIGEG QQSKSIVAMP SDQVPAKIAS1320
 1321 FDDTFTATFK EDAKMPCLAV GAPQPEITWK IKGVEFSAND RMRVLPDGSL LIKSVNRQDA1380
 1381 GDYSCHAENS IAKDSITHKL IVLAPPQSPH VTLSATTTDA LTVKLKPHEG DTAPLHGYTL1440
 1441 HYKPEFGEWE TSEVSVDSQK HNIEGLLCGS RYQVYATGFN NIGAGEASDI LNTRTKGQKP1500
 1501 KLPEKPRFIE VSSNSVSLHF KAWKDGGCPM SHFVVESKKR DQIEWNQISN NVKPDNNYVV1560
 1561 LDLEPATWYN LRITAHNSAG FTVAEYDFAT LTVTGGTIAP LDDGSGHGNV HTRIRLPAWM1620
 1621 PEWLDLNFMV PLIATVVVVA VGICVVCVAL SRRRADDMRG GQKDVYYDVV YNQTMGPGAT1680
 1681 LDKRRPDLRD ELGYIAPPNR KLPPVPGSNY NTCDRIKRGR GGLRSNHSTW DPRRNPNLYE1740
 1741 ELKAPPVPMH GNHYGHAHGN AECHYRHPGM EDEICPYATF HLLGFREEMD PTKAMNFQTF1800
 1801 PHQNGHAGPV PGHAGTMLPP GHPGHVHSRS GSQSMPRANR YQRKNSQGGQ SSIYTPAPEY1860
 1861 DDPANCAEED QYRRYTRVNS QGGSLYSGPG PEYDDPANCA PEEDQYGSQY GGPYGQPYDH1920
 1921 YGSRGSMGRR SIGSARNPGN GSPEPPPPPP RNHDMSNSSF NDSKESNEIS EAECDRDHGP1980
 1981 RGNYGAVKRS PQPKDQRTTE EMRKLIERNE TGPKQLQLQQ ANGAGFTAYD TMAV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..246] PSI-BLAST 76.154902 No description for 2v5sA was found.
    2 View Details [247..897] PSI-BLAST 56.0 Model of human carcinoembryonic antigen by homology modelling and curve-fitting to experimental solution scattering data
    3 View Details [898..999] PSI-BLAST 35.221849 No description for 2nziA was found.
    4 View Details [1000..1105] FFAS03 6.22 Solution Structure of The Third Fibronectin III Domain of Human KIAA0343 Protein
    5 View Details [1106..1217] PSI-BLAST 19.69897 Integin beta-4 subunit
    6 View Details [1218..1726] PSI-BLAST 23.0 No description for 2v5yA was found.
    7 View Details [1727..1868] deduced N/A No confident structure predictions are available.
    8 View Details [1869..2034] MSA 4.099995 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • telethonin binding
    		•  5.64191752950322 bayes_pls_golite062009
  • structural constituent of muscle
    		•  5.48327952154215 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  4.5103765150253 bayes_pls_golite062009
  • actinin binding
    		•  4.48149264004887 bayes_pls_golite062009
  • alpha-actinin binding
    		•  4.45867823077829 bayes_pls_golite062009
  • receptor activity
    		•  4.37793227341148 bayes_pls_golite062009
  • ankyrin binding
    		•  4.3701493214749 bayes_pls_golite062009
  • cytokine binding
    		•  3.96036354316187 bayes_pls_golite062009
  • growth factor binding
    		•  3.72927884588092 bayes_pls_golite062009
  • cytokine receptor activity
    		•  3.56710042152924 bayes_pls_golite062009
  • molecular transducer activity
    		•  3.48919490776358 bayes_pls_golite062009
  • signal transducer activity
    		•  3.48919490776358 bayes_pls_golite062009
  • extracellular matrix structural constituent
    		•  3.42134839153875 bayes_pls_golite062009
  • protein binding
    		•  3.07386271831775 bayes_pls_golite062009
  • binding
    		•  3.01297199434173 bayes_pls_golite062009
  • receptor binding
    		•  2.24607683514744 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  2.10516556578644 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.79394027888496 bayes_pls_golite062009
  • peptide hormone binding
    		•  1.75574680918945 bayes_pls_golite062009
  • axon guidance receptor activity
    		•  1.63462880446774 bayes_pls_golite062009
  • mercury ion binding
    		•  1.51606310151325 bayes_pls_golite062009
  • prolactin receptor activity
    		•  1.50469234952074 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  1.44108205374377 bayes_pls_golite062009
  • protein kinase activity
    		•  1.43845497070856 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.33776468784285 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.33202923701908 bayes_pls_golite062009
  • myosin light chain kinase activity
    		•  1.31623717161573 bayes_pls_golite062009
  • interleukin-2 binding
    		•  1.23418025988474 bayes_pls_golite062009
  • actin binding
    		•  1.2168514525128 bayes_pls_golite062009
  • DNA binding
    		•  1.20974701505243 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.17433712680111 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.14375759905113 bayes_pls_golite062009
  • kinase activity
    		•  1.1286195376114 bayes_pls_golite062009
  • heparin binding
    		•  1.00503605071474 bayes_pls_golite062009
  • cytokine activity
    		•  0.961912275787352 bayes_pls_golite062009
  • structural molecule activity
    		•  0.891799491886048 bayes_pls_golite062009
  • ciliary neurotrophic factor receptor activity
    		•  0.799335410052588 bayes_pls_golite062009
  • peptide binding
    		•  0.758731415132682 bayes_pls_golite062009
  • growth hormone receptor activity
    		•  0.745160473538126 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.705756302293137 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.674567146312744 bayes_pls_golite062009
  • transcription factor activity
    		•  0.565342916629949 bayes_pls_golite062009
  • kinase binding
    		•  0.557489547407687 bayes_pls_golite062009
  • collagen binding
    		•  0.552918322648406 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  0.541677628277769 bayes_pls_golite062009
  • enzyme binding
    		•  0.473046788409936 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.452957099078474 bayes_pls_golite062009
  • interleukin-6 binding
    		•  0.42567751386992 bayes_pls_golite062009
  • interleukin-6 receptor activity
    		•  0.42567751386992 bayes_pls_golite062009
  • polysaccharide binding
    		•  0.411488590314852 bayes_pls_golite062009
  • growth factor activity
    		•  0.39892291470381 bayes_pls_golite062009
  • identical protein binding
    		•  0.368517091723107 bayes_pls_golite062009
  • pattern binding
    		•  0.326372030550655 bayes_pls_golite062009
  • protein kinase binding
    		•  0.316279870541718 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.284349891897882 bayes_pls_golite062009
  • cytokine receptor binding
    		•  0.277412437701811 bayes_pls_golite062009
  • cell surface binding
    		•  0.276299257835729 bayes_pls_golite062009
  • leukemia inhibitory factor receptor activity
    		•  0.214351244071116 bayes_pls_golite062009
  • oncostatin-M receptor activity
    		•  0.214351244071116 bayes_pls_golite062009
  • hormone binding
    		•  0.19211161691603 bayes_pls_golite062009
  • actin filament binding
    		•  0.121647948863501 bayes_pls_golite062009
  • transcription activator activity
    		•  0.0790192907314051 bayes_pls_golite062009
  • transcription factor binding
    		•  0.013959055851287 bayes_pls_golite062009
  • integrin binding
    		•  0.013361887492048 bayes_pls_golite062009
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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