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Protein Overview: Dscam-PAX

General Information:
Name(s) found: Dscam-PAX / FBpp0110364 [FlyBase]
Description(s) found:
Found 16 descriptions.
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  • The gene Down syndrome cell adhesion molecule is referred to in FlyBase by the symbol Dmel\Dscam (CG17800, FBgn0033159). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:3207059..3269374. It has the cytological map location 43A4-43B1. There is experimental evidence that it has the molecular function</span>: protein binding; bacterial binding; protein homodimerization activity; axon guidance receptor activity. There is experimental evidence that it is involved in the biological process</span>: dendrite self-avoidance; axon extension involved in axon guidance; axon guidance; phagocytosis; central nervous system morphogenesis; neuron development; axonal fasciculation; mushroom body development; peripheral nervous system development. 120 alleles are reported. The phenotypes of these alleles are annotated with 18 unique terms, many of which group under: nervous system; multi-cell-component structure; organ system; adult segment; embryonic nervous system; commissure; antennal segment; adult brain; peripheral nervous system; mushroom body. It has 59 annotated transcripts and 59 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 2019 amino acids

    Gene Ontology:
    Cellular Component: integral to plasma membrane [ISS]
    dendrite [IDA]
    neuronal cell body [IDA]
    axon [IDA]
    Biological Process: mushroom body development [IMP]
    dendrite self-avoidance [IDA][IMP]
    phagocytosis [IMP]
    axon guidance [IGI][IMP][TAS]
    peripheral nervous system development [IMP]
    neuron development [IMP]
    central nervous system morphogenesis [IMP]
    axonal fasciculation [IMP]
    axon extension involved in axon guidance [IMP]
    Molecular Function: protein binding [IDA]
    protein homodimerization activity [IPI]
    axon guidance receptor activity [IMP][NAS]
    bacterial cell surface binding [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNMPNERLKW LMLFAAVALI ACGSQTLAAN PPDADQKGPV FLKEPTNRID FSNSTGAEIE  60
   61 CKASGNPMPE IIWIRSDGTA VGDVPGLRQI SSDGKLVFPP FRAEDYRQEV HAQVYACLAR 120
  121 NQFGSIISRD VHVRAVVHQF YQTRVIDEFV LRGNSATLKC LVPSFVADFI DVEGWIDEEG 180
  181 VEILRPLPDD SVDGKYLVLP SGELHIREVG PEDGYKSYQC RTKHRLTGET RLSATKGRLV 240
  241 ITEPIGARAP TFSTDSNSFS YTRSVGQSFA LLCQAQAYPV PIMRWYKFIE GTTRKQAVVL 300
  301 NDRVKQVSGT LIIKDAVVED SGKYLCVVNN SVGGESVETV LTVTAPLSAK IDPPTQTVDF 360
  361 GRPAVFTCQY TGNPIKTVSW MKDGKAIGHS EPVLRIESVK KEDKGMYQCF VRNDQESAEA 420
  421 SAELKLGGRF DPPVIRQAFQ EETMEPGPSV FLKCVAGGNP TPEISWELDG KKIANNDRYQ 480
  481 VGQYVTVNGD VVSYLNITSV HANDGGLYKC IAKSKVGVAE HSAKLNVYGL PYIRQMEKKA 540
  541 IVAGETLIVT CPVAGYPIDS IVWERDNRAL PINRKQKVFP NGTLIIENVE RNSDQATYTC 600
  601 VAKNQEGYSA RGSLEVQVMV PPKITPFDFG DAPTNVEDSV SVMCLISNGD LPIDIEWFFN 660
  661 DYGISSYSGI NVVKGGKRNS MLSIDSVQAR HAGKYSCRAK NHAAAVNYTT ELIVNVPPRW 720
  721 ILEPTDKAFA QGSDAKVECK ADGFPKPQVT WKKAVGDTPG EYKDLKKSDN IRVEEGTLHV 780
  781 DNIQKTNEGY YLCEAINGIG SGLSAVIMIS VQAPPEFTEK LRNQTARRGE PAVLQCEAKG 840
  841 EKPIGILWNM NNMRLDPKND NRYTIREEIL STGVMSSLSI KRTERSDSAL FTCVATNAFG 900
  901 SDDASINMIV QEVPEMPYAL KVLDKSGRSV QLSWAQPYDG NSPLDRYIIE FKRSRASWSE 960
  961 IDRVIVPGHT TEAQVQKLSP ATTYNIRIVA ENAIGTSQSS EAVTIITAEE APSGKPQNIK1020
 1021 VEPVNQTTMR VTWKPPPRTE WNGEILGYYV GYKLSNTNSS YVFETINFIT EEGKEHNLEL1080
 1081 QNLRVYTQYS VVIQAFNKIG AGPLSEEEKQ FTAEGTPSQP PSDTACTTLT SQTIRVGWVS1140
 1141 PPLESANGVI KTYKVVYAPS DEWYDETKRH YKKTASSDTV LHGLKKYTNY TMQVLATTAG1200
 1201 GDGVRSVPIH CQTEPDVPEA PTDVKALVMG NAAILVSWRP PAQPNGIITQ YTVYSKAEGA1260
 1261 ETETKTQKVP HYQMSFEATE LEKNKPYEFW VTASTTIGEG QQSKSIVAMP SDQVPAKIAS1320
 1321 FDDTFTATFK EDAKMPCLAV GAPQPEITWK IKGVEFSAND RMRVLPDGSL LIKSVNRQDA1380
 1381 GDYSCHAENS IAKDSITHKL IVLAPPQSPH VTLSATTTDA LTVKLKPHEG DTAPLHGYTL1440
 1441 HYKPEFGEWE TSEVSVDSQK HNIEGLLCGS RYQVYATGFN NIGAGEASDI LNTRTKGQKP1500
 1501 KLPEKPRFIE VSSNSVSLHF KAWKDGGCPM SHFVVESKKR DQIEWNQISN NVKPDNNYVV1560
 1561 LDLEPATWYN LRITAHNSAG FTVAEYDFAT LTVTGGTIAP SRDLPELSAE DTIRIILSNL1620
 1621 NLVVPVVAAL LVIIIAIIVI CILRSKGNHH KDDVVYNQTM GPGATLDKRR PDLRDELGYI1680
 1681 APPNRKLPPV PGSNYNTCDR IKRGRGGLRS NHSTWDPRRN PNLYEELKAP PVPMHGNHYG1740
 1741 HAHGNAECHY RHPGMEDEIC PYATFHLLGF REEMDPTKAM NFQTFPHQNG HAGPVPGHAG1800
 1801 TMLPPGHPGH VHSRSGSQSM PRANRYQRKN SQGGQSSIYT PAPEYDDPAN CAEEDQYRRY1860
 1861 TRVNSQGGSL YSGPGPEYDD PANCAPEEDQ YGSQYGGPYG QPYDHYGSRG SMGRRSIGSA1920
 1921 RNPGNGSPEP PPPPPRNHDM SNSSFNDSKE SNEISEAECD RDHGPRGNYG AVKRSPQPKD1980
 1981 QRTTEEMRKL IERNETGPKQ LQLQQANGAG FTAYDTMAV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..143] PSI-BLAST 79.69897 No description for 2v5sA was found.
    2 View Details [144..242] PSI-BLAST 13.09691 Immunoglobulin light chain kappa variable domain, VL-kappa; Immunoglobulin heavy chain variable domain, VH
    3 View Details [243..898] PSI-BLAST 58.522879 Model of human carcinoembryonic antigen by homology modelling and curve-fitting to experimental solution scattering data
    4 View Details [899..1374] PSI-BLAST 27.69897 No description for 2v5yA was found.
    5 View Details [1375..1595] PSI-BLAST 23.30103 Fibronectin, different Fn3 modules
    6 View Details [1596..1843] deduced N/A No confident structure predictions are available.
    7 View Details [1844..2019] MSA 2.125995 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • telethonin binding
    		•  6.64811984458494 bayes_pls_golite062009
  • alpha-actinin binding
    		•  5.77350124471385 bayes_pls_golite062009
  • actinin binding
    		•  5.69539760434923 bayes_pls_golite062009
  • structural constituent of muscle
    		•  4.93896503565413 bayes_pls_golite062009
  • olfactory receptor activity
    		•  4.21057154107121 bayes_pls_golite062009
  • receptor activity
    		•  4.00123250685257 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  3.81769911097805 bayes_pls_golite062009
  • binding
    		•  3.17641566810715 bayes_pls_golite062009
  • molecular transducer activity
    		•  3.10913345555941 bayes_pls_golite062009
  • signal transducer activity
    		•  3.10913345555941 bayes_pls_golite062009
  • peptide antigen binding
    		•  2.94721224577771 bayes_pls_golite062009
  • fibroblast growth factor 1 binding
    		•  2.83860944503193 bayes_pls_golite062009
  • growth factor binding
    		•  2.28613301180608 bayes_pls_golite062009
  • protein binding
    		•  2.22855404705168 bayes_pls_golite062009
  • IgG binding
    		•  1.92633562075074 bayes_pls_golite062009
  • antigen binding
    		•  1.63189745559168 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.58610597245454 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  1.52958974617075 bayes_pls_golite062009
  • actin binding
    		•  1.42681407553255 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  1.36789541796983 bayes_pls_golite062009
  • protein kinase activity
    		•  1.36635494500222 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.32330470851159 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  1.30657787244536 bayes_pls_golite062009
  • fibroblast growth factor binding
    		•  1.27793818082552 bayes_pls_golite062009
  • fibroblast growth factor receptor activity
    		•  1.24730237107473 bayes_pls_golite062009
  • DNA binding
    		•  1.19412627500732 bayes_pls_golite062009
  • myosin light chain kinase activity
    		•  1.17845072849922 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.16252234499274 bayes_pls_golite062009
  • G-protein coupled receptor activity
    		•  1.02428106476324 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.02286631988334 bayes_pls_golite062009
  • kinase activity
    		•  0.929878054374821 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.878595022643164 bayes_pls_golite062009
  • protein complex binding
    		•  0.83543827718565 bayes_pls_golite062009
  • actin filament binding
    		•  0.760856470721016 bayes_pls_golite062009
  • collagen binding
    		•  0.729893120256353 bayes_pls_golite062009
  • peptide binding
    		•  0.729048089532569 bayes_pls_golite062009
  • receptor binding
    		•  0.632627479346393 bayes_pls_golite062009
  • cytokine binding
    		•  0.631436442105379 bayes_pls_golite062009
  • titin binding
    		•  0.599892148302011 bayes_pls_golite062009
  • integrin binding
    		•  0.599569390248921 bayes_pls_golite062009
  • structural molecule activity
    		•  0.567620977360967 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.564762108830441 bayes_pls_golite062009
  • transcription factor activity
    		•  0.54549168007511 bayes_pls_golite062009
  • myosin heavy chain binding
    		•  0.49788128784685 bayes_pls_golite062009
  • cytokine receptor activity
    		•  0.34165331857492 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  0.318890055375093 bayes_pls_golite062009
  • cell surface binding
    		•  0.213817211551667 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.0579247757286607 bayes_pls_golite062009
  • transferase activity
    		•  0.053007146193305 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • telethonin binding
    		•  5.81747667416248 bayes_pls_golite062009
  • structural constituent of muscle
    		•  5.71979489668015 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  4.81256300373074 bayes_pls_golite062009
  • ankyrin binding
    		•  4.69755754047169 bayes_pls_golite062009
  • receptor activity
    		•  4.66147271961356 bayes_pls_golite062009
  • alpha-actinin binding
    		•  4.57951951779666 bayes_pls_golite062009
  • actinin binding
    		•  4.57900103206288 bayes_pls_golite062009
  • cytokine binding
    		•  4.43581512268554 bayes_pls_golite062009
  • cytokine receptor activity
    		•  4.08668869714207 bayes_pls_golite062009
  • growth factor binding
    		•  4.06808996928726 bayes_pls_golite062009
  • molecular transducer activity
    		•  3.69234048247377 bayes_pls_golite062009
  • signal transducer activity
    		•  3.69234048247377 bayes_pls_golite062009
  • protein binding
    		•  3.24522318184038 bayes_pls_golite062009
  • binding
    		•  3.12471204223368 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  2.32179186005318 bayes_pls_golite062009
  • peptide hormone binding
    		•  2.12033076929638 bayes_pls_golite062009
  • axon guidance receptor activity
    		•  2.01367445237355 bayes_pls_golite062009
  • prolactin receptor activity
    		•  1.9556649101819 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.85720106085239 bayes_pls_golite062009
  • interleukin-2 binding
    		•  1.67132604890013 bayes_pls_golite062009
  • myosin light chain kinase activity
    		•  1.49217960276915 bayes_pls_golite062009
  • protein kinase activity
    		•  1.42856560840953 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.32813363771214 bayes_pls_golite062009
  • receptor binding
    		•  1.31676259534833 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.31663344632755 bayes_pls_golite062009
  • actin binding
    		•  1.21472460452555 bayes_pls_golite062009
  • DNA binding
    		•  1.2006039770643 bayes_pls_golite062009
  • growth hormone receptor activity
    		•  1.15929762138929 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.15899955607967 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.12142142875217 bayes_pls_golite062009
  • kinase activity
    		•  1.11027658115625 bayes_pls_golite062009
  • ciliary neurotrophic factor receptor activity
    		•  1.07748328484506 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  0.99058387466784 bayes_pls_golite062009
  • structural molecule activity
    		•  0.94240190391222 bayes_pls_golite062009
  • peptide binding
    		•  0.92031154055894 bayes_pls_golite062009
  • interleukin-6 receptor activity
    		•  0.888638861691021 bayes_pls_golite062009
  • interleukin-6 binding
    		•  0.888638861691021 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.86564366658585 bayes_pls_golite062009
  • cell surface binding
    		•  0.792329562040096 bayes_pls_golite062009
  • heparin binding
    		•  0.7054081997714 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.703490254739121 bayes_pls_golite062009
  • collagen binding
    		•  0.688581536921572 bayes_pls_golite062009
  • kinase binding
    		•  0.65927255037265 bayes_pls_golite062009
  • oncostatin-M receptor activity
    		•  0.628488391922279 bayes_pls_golite062009
  • leukemia inhibitory factor receptor activity
    		•  0.628488391922279 bayes_pls_golite062009
  • enzyme binding
    		•  0.60195860585095 bayes_pls_golite062009
  • identical protein binding
    		•  0.564711394496051 bayes_pls_golite062009
  • transcription factor activity
    		•  0.557290274937694 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  0.554350228628563 bayes_pls_golite062009
  • hormone binding
    		•  0.49524185948356 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.46168925186147 bayes_pls_golite062009
  • transferase activity
    		•  0.432850266451294 bayes_pls_golite062009
  • polysaccharide binding
    		•  0.4326581122899 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.40600177052491 bayes_pls_golite062009
  • protein kinase binding
    		•  0.405060010394646 bayes_pls_golite062009
  • interleukin-7 binding
    		•  0.301052531308189 bayes_pls_golite062009
  • pattern binding
    		•  0.30071837231983 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.1430595594485 bayes_pls_golite062009
  • transcription activator activity
    		•  0.135753557343301 bayes_pls_golite062009
  • actin filament binding
    		•  0.135484838710405 bayes_pls_golite062009
  • protein homodimerization activity
    		•  0.116391819218123 bayes_pls_golite062009
  • interleukin-2 receptor activity
    		•  0.115337814289139 bayes_pls_golite062009
  • integrin binding
    		•  0.0873424694168858 bayes_pls_golite062009
  • transcription factor binding
    		•  0.075900818564989 bayes_pls_golite062009
    6 No functions predicted.
    7 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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