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Protein Overview: UCP3

General Information:
Name(s) found: UCP3 [HGNC (HUGO)]
Description(s) found:
Found 34 descriptions.
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  • uncoupling protein 3 (mitochondrial, proton carrier) [HGNC (HUGO)]
    • Organism: Homo sapiens
    Length: 312 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVGLKPSDVP PTMAVKFLGA GTAACFADLV TFPLDTAKVR LQIQGENQAV QTARLVQYRG  60
   61 VLGTILTMVR TEGPCSPYNG LVAGLQRQMS FASIRIGLYD SVKQVYTPKG ADNSSLTTRI 120
  121 LAGCTTGAMA VTCAQPTDVV KVRFQASIHL GPSRSDRKYS GTMDAYRTIA REEGVRGLWK 180
  181 GTLPNIMRNA IVNCAEVVTY DILKEKLLDY HLLTDNFPCH FVSAFGAGFC ATVVASPVDV 240
  241 VKTRYMNSPP GQYFSPLDCM IKMVAQEGPT AFYKGFTPSF LRLGSWNVVM FVTYEQLKRA 300
  301 LMKVQMLRES PF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..312] PSI-BLAST 74.522879 structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ATP:ADP antiporter activity
    		•  8.2187613686669 bayes_pls_golite062009
  • cofactor transporter activity
    		•  7.95943961121366 bayes_pls_golite062009
  • nucleotide transmembrane transporter activity
    		•  7.56905103125996 bayes_pls_golite062009
  • coenzyme transporter activity
    		•  7.28560757075559 bayes_pls_golite062009
  • coenzyme A transmembrane transporter activity
    		•  7.28560757075559 bayes_pls_golite062009
  • vitamin transporter activity
    		•  6.71317302700612 bayes_pls_golite062009
  • oxoglutarate:malate antiporter activity
    		•  6.68782546722632 bayes_pls_golite062009
  • dicarboxylic acid transmembrane transporter activity
    		•  6.30725697950774 bayes_pls_golite062009
  • carnitine:acyl carnitine antiporter activity
    		•  6.21624015775577 bayes_pls_golite062009
  • folic acid transporter activity
    		•  5.8811731252653 bayes_pls_golite062009
  • NAD transporter activity
    		•  5.53453276501873 bayes_pls_golite062009
  • succinate transmembrane transporter activity
    		•  5.53453276501873 bayes_pls_golite062009
  • L-aspartate transmembrane transporter activity
    		•  5.44161267718598 bayes_pls_golite062009
  • adenine nucleotide transmembrane transporter activity
    		•  5.24071069508231 bayes_pls_golite062009
  • purine nucleotide transmembrane transporter activity
    		•  5.24071069508231 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  5.22388315120586 bayes_pls_golite062009
  • tricarboxylate secondary active transmembrane transporter activity
    		•  5.1674847744258 bayes_pls_golite062009
  • pyrimidine nucleotide transmembrane transporter activity
    		•  5.12006083109254 bayes_pls_golite062009
  • nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity
    		•  5.118402892479 bayes_pls_golite062009
  • transporter activity
    		•  4.89326331095268 bayes_pls_golite062009
  • adenine transmembrane transporter activity
    		•  4.83924735687092 bayes_pls_golite062009
  • sulfate transmembrane transporter activity
    		•  4.51079491235732 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  4.42892693755356 bayes_pls_golite062009
  • organic acid transmembrane transporter activity
    		•  4.41254441726167 bayes_pls_golite062009
  • anion transmembrane transporter activity
    		•  4.3966395498876 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  4.32921072480881 bayes_pls_golite062009
  • carboxylic acid transmembrane transporter activity
    		•  4.32475594578306 bayes_pls_golite062009
  • quaternary ammonium group transmembrane transporter activity
    		•  4.23740010613999 bayes_pls_golite062009
  • acyl carnitine transporter activity
    		•  4.23740010613999 bayes_pls_golite062009
  • carnitine transporter activity
    		•  4.23740010613999 bayes_pls_golite062009
  • oxaloacetate secondary active transmembrane transporter activity
    		•  4.12764886082077 bayes_pls_golite062009
  • secondary active sulfate transmembrane transporter activity
    		•  4.12764886082077 bayes_pls_golite062009
  • oxaloacetate transmembrane transporter activity
    		•  4.12764886082077 bayes_pls_golite062009
  • ATP transmembrane transporter activity
    		•  4.0113184039145 bayes_pls_golite062009
  • ADP transmembrane transporter activity
    		•  4.0113184039145 bayes_pls_golite062009
  • organic cation transmembrane transporter activity
    		•  3.96715292382728 bayes_pls_golite062009
  • inorganic anion transmembrane transporter activity
    		•  3.92244074242803 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  3.85693924451156 bayes_pls_golite062009
  • deoxynucleotide transmembrane transporter activity
    		•  3.68260258301559 bayes_pls_golite062009
  • isopropylmalate transmembrane transporter activity
    		•  3.68260258301559 bayes_pls_golite062009
  • oxidative phosphorylation uncoupler activity
    		•  3.48258668647635 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  3.4762270931683 bayes_pls_golite062009
  • acidic amino acid transmembrane transporter activity
    		•  3.44338179030962 bayes_pls_golite062009
  • L-glutamate transmembrane transporter activity
    		•  3.44338179030962 bayes_pls_golite062009
  • antiporter activity
    		•  3.37961755872774 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  3.35045645260901 bayes_pls_golite062009
  • amine transmembrane transporter activity
    		•  3.34826241325069 bayes_pls_golite062009
  • solute:solute antiporter activity
    		•  3.12356777883639 bayes_pls_golite062009
  • thiosulfate transmembrane transporter activity
    		•  2.94358474593615 bayes_pls_golite062009
  • fumarate transmembrane transporter activity
    		•  2.94358474593615 bayes_pls_golite062009
  • pyruvate transmembrane transporter activity
    		•  2.94358474593615 bayes_pls_golite062009
  • succinate:fumarate antiporter activity
    		•  2.94358474593615 bayes_pls_golite062009
  • pyruvate secondary active transmembrane transporter activity
    		•  2.94358474593615 bayes_pls_golite062009
  • malate transmembrane transporter activity
    		•  2.94358474593615 bayes_pls_golite062009
  • phosphate transmembrane transporter activity
    		•  2.91773338653529 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  2.91298382599604 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  2.85243863885516 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  2.61999622644439 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  2.23624614645688 bayes_pls_golite062009
  • L-amino acid transmembrane transporter activity
    		•  2.05701098131271 bayes_pls_golite062009
  • secondary active transmembrane transporter activity
    		•  2.04402290526471 bayes_pls_golite062009
  • amino acid transmembrane transporter activity
    		•  1.79011710526545 bayes_pls_golite062009
  • thiamin transmembrane transporter activity
    		•  1.78614074729949 bayes_pls_golite062009
  • transition metal ion transmembrane transporter activity
    		•  1.63679790939923 bayes_pls_golite062009
  • binding
    		•  1.2410456967979 bayes_pls_golite062009
  • di-, tri-valent inorganic cation transmembrane transporter activity
    		•  0.689323439815548 bayes_pls_golite062009
  • iron ion transmembrane transporter activity
    		•  0.485322129024458 bayes_pls_golite062009
  • purine transmembrane transporter activity
    		•  0.32947646869018 bayes_pls_golite062009
  • nucleobase transmembrane transporter activity
    		•  0.32947646869018 bayes_pls_golite062009
  • anion:anion antiporter activity
    		•  0.290242584029341 bayes_pls_golite062009
  • protein binding
    		•  0.062534364616511 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.46

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle