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Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. Catalysis of the transfer of protons from mitochondrial intermembrane space into mitochondrial matrix, dissipating the proton gradient across the mitochondrial inner membrane established by the electron transport chain during the oxidative phosphorylation (proton leak). Proton leak uncouples the processes of electron transport/proton generation and ATP synthesis. Enables the transfer of a substance from one side of a membrane to the other. Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hydrophobic uncoupler(in) + H+(out) = hydrophobic uncoupler(out) + H+(in). Hydrophobic uncouplers include CCCP, benzalkonium and SDS.

View Gene Ontology (GO) Term

GO TERM SUMMARY

Name: oxidative phosphorylation uncoupler activity
Acc: GO:0017077
Aspect: Molecular Function
Desc: Catalysis of the transfer of protons from mitochondrial intermembrane space into mitochondrial matrix, dissipating the proton gradient across the mitochondrial inner membrane established by the electron transport chain during the oxidative phosphorylation (proton leak). Proton leak uncouples the processes of electron transport/proton generation and ATP synthesis.
Synonyms:
  • GO:0015302
  • uncoupling protein activity
  • mitochondrial uncoupling protein activity
Proteins in PDR annotated with:
   This term: 13 [Search]
   Term or descendants: 13 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0017077 - oxidative phosphorylation uncoupler activity (interactive image map)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle