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View Structure Prediction Details

Protein: UCP3
Organism: Homo sapiens
Length: 312 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for UCP3.

Description E-value Query
Range		 Subject
Range
gi|109107897 - gi|109107897|ref|XP_001115599.1| PREDICTED: uncoupling protein 3 [Macaca mulatta]
 4.0E-82 [1..312] [1..312]
UCP3_CANLF - Mitochondrial uncoupling protein 3 OS=Canis lupus familiaris GN=UCP3 PE=2 SV=1
 6.0E-82 [1..312] [1..311]
UCP3_BOVIN - Mitochondrial uncoupling protein 3 OS=Bos taurus GN=UCP3 PE=2 SV=1
 6.0E-82 [1..312] [1..311]
gi|53829363, gi|... - gi|53829363|gb|AAU94638.1| uncoupling protein 3 [Sus scrofa], gi|4928052|gb|AAD33396.1| uncoupling p...
 1.0E-81 [1..312] [1..311]
gi|3176760 - gi|3176760|gb|AAC18822.1| uncoupling protein 3 [Homo sapiens]
 1.0E-81 [1..312] [1..312]
gi|114639340, gi... - gi|114639340|ref|XP_001174875.1| PREDICTED: uncoupling protein 3 isoform 4 [Pan troglodytes], gi|114...
 5.0E-80 [1..312] [1..312]
gi|42742053 - gi|42742053|gb|AAS45212.1| mitochondrial uncoupling protein 3 [Antechinus flavipes]
 2.0E-79 [1..312] [1..311]

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Predicted Domain #1
Region A:
Residues: [1-312] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVGLKPSDVP PTMAVKFLGA GTAACFADLV TFPLDTAKVR LQIQGENQAV QTARLVQYRG  60
   61 VLGTILTMVR TEGPCSPYNG LVAGLQRQMS FASIRIGLYD SVKQVYTPKG ADNSSLTTRI 120
  121 LAGCTTGAMA VTCAQPTDVV KVRFQASIHL GPSRSDRKYS GTMDAYRTIA REEGVRGLWK 180
  181 GTLPNIMRNA IVNCAEVVTY DILKEKLLDY HLLTDNFPCH FVSAFGAGFC ATVVASPVDV 240
  241 VKTRYMNSPP GQYFSPLDCM IKMVAQEGPT AFYKGFTPSF LRLGSWNVVM FVTYEQLKRA 300
  301 LMKVQMLRES PF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 74.522879
Match: 1okcA
Description: structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ATP:ADP antiporter activity 8.2187613686669 bayes_pls_golite062009
cofactor transporter activity 7.95943961121366 bayes_pls_golite062009
nucleotide transmembrane transporter activity 7.56905103125996 bayes_pls_golite062009
coenzyme transporter activity 7.28560757075559 bayes_pls_golite062009
coenzyme A transmembrane transporter activity 7.28560757075559 bayes_pls_golite062009
vitamin transporter activity 6.71317302700612 bayes_pls_golite062009
oxoglutarate:malate antiporter activity 6.68782546722632 bayes_pls_golite062009
dicarboxylic acid transmembrane transporter activity 6.30725697950774 bayes_pls_golite062009
carnitine:acyl carnitine antiporter activity 6.21624015775577 bayes_pls_golite062009
folic acid transporter activity 5.8811731252653 bayes_pls_golite062009
NAD transporter activity 5.53453276501873 bayes_pls_golite062009
succinate transmembrane transporter activity 5.53453276501873 bayes_pls_golite062009
L-aspartate transmembrane transporter activity 5.44161267718598 bayes_pls_golite062009
adenine nucleotide transmembrane transporter activity 5.24071069508231 bayes_pls_golite062009
purine nucleotide transmembrane transporter activity 5.24071069508231 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 5.22388315120586 bayes_pls_golite062009
tricarboxylate secondary active transmembrane transporter activity 5.1674847744258 bayes_pls_golite062009
pyrimidine nucleotide transmembrane transporter activity 5.12006083109254 bayes_pls_golite062009
nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity 5.118402892479 bayes_pls_golite062009
transporter activity 4.89326331095268 bayes_pls_golite062009
adenine transmembrane transporter activity 4.83924735687092 bayes_pls_golite062009
sulfate transmembrane transporter activity 4.51079491235732 bayes_pls_golite062009
transmembrane transporter activity 4.42892693755356 bayes_pls_golite062009
organic acid transmembrane transporter activity 4.41254441726167 bayes_pls_golite062009
anion transmembrane transporter activity 4.3966395498876 bayes_pls_golite062009
ion transmembrane transporter activity 4.32921072480881 bayes_pls_golite062009
carboxylic acid transmembrane transporter activity 4.32475594578306 bayes_pls_golite062009
quaternary ammonium group transmembrane transporter activity 4.23740010613999 bayes_pls_golite062009
acyl carnitine transporter activity 4.23740010613999 bayes_pls_golite062009
carnitine transporter activity 4.23740010613999 bayes_pls_golite062009
oxaloacetate secondary active transmembrane transporter activity 4.12764886082077 bayes_pls_golite062009
secondary active sulfate transmembrane transporter activity 4.12764886082077 bayes_pls_golite062009
oxaloacetate transmembrane transporter activity 4.12764886082077 bayes_pls_golite062009
ATP transmembrane transporter activity 4.0113184039145 bayes_pls_golite062009
ADP transmembrane transporter activity 4.0113184039145 bayes_pls_golite062009
organic cation transmembrane transporter activity 3.96715292382728 bayes_pls_golite062009
inorganic anion transmembrane transporter activity 3.92244074242803 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 3.85693924451156 bayes_pls_golite062009
deoxynucleotide transmembrane transporter activity 3.68260258301559 bayes_pls_golite062009
isopropylmalate transmembrane transporter activity 3.68260258301559 bayes_pls_golite062009
oxidative phosphorylation uncoupler activity 3.48258668647635 bayes_pls_golite062009
cation transmembrane transporter activity 3.4762270931683 bayes_pls_golite062009
acidic amino acid transmembrane transporter activity 3.44338179030962 bayes_pls_golite062009
L-glutamate transmembrane transporter activity 3.44338179030962 bayes_pls_golite062009
antiporter activity 3.37961755872774 bayes_pls_golite062009
substrate-specific transporter activity 3.35045645260901 bayes_pls_golite062009
amine transmembrane transporter activity 3.34826241325069 bayes_pls_golite062009
solute:solute antiporter activity 3.12356777883639 bayes_pls_golite062009
thiosulfate transmembrane transporter activity 2.94358474593615 bayes_pls_golite062009
fumarate transmembrane transporter activity 2.94358474593615 bayes_pls_golite062009
pyruvate transmembrane transporter activity 2.94358474593615 bayes_pls_golite062009
succinate:fumarate antiporter activity 2.94358474593615 bayes_pls_golite062009
pyruvate secondary active transmembrane transporter activity 2.94358474593615 bayes_pls_golite062009
malate transmembrane transporter activity 2.94358474593615 bayes_pls_golite062009
phosphate transmembrane transporter activity 2.91773338653529 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 2.91298382599604 bayes_pls_golite062009
metal ion transmembrane transporter activity 2.85243863885516 bayes_pls_golite062009
active transmembrane transporter activity 2.61999622644439 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 2.23624614645688 bayes_pls_golite062009
L-amino acid transmembrane transporter activity 2.05701098131271 bayes_pls_golite062009
secondary active transmembrane transporter activity 2.04402290526471 bayes_pls_golite062009
amino acid transmembrane transporter activity 1.79011710526545 bayes_pls_golite062009
thiamin transmembrane transporter activity 1.78614074729949 bayes_pls_golite062009
transition metal ion transmembrane transporter activity 1.63679790939923 bayes_pls_golite062009
binding 1.2410456967979 bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity 0.689323439815548 bayes_pls_golite062009
iron ion transmembrane transporter activity 0.485322129024458 bayes_pls_golite062009
purine transmembrane transporter activity 0.32947646869018 bayes_pls_golite062009
nucleobase transmembrane transporter activity 0.32947646869018 bayes_pls_golite062009
anion:anion antiporter activity 0.290242584029341 bayes_pls_golite062009
protein binding 0.062534364616511 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle