Protein Overview: MCM7

General Information:
Name(s) found:	MCM7 [HGNC (HUGO)]
Description(s) found: SHOW ONLY BEST	gi\|51094603\|gb\|EAL23855.1\| MCM7 minichromosome maintenance deficient 7 (S. cerevisiae) [Homo sapiens] [NCBI NR] gi\|33469968\|ref\|NP_005907.3\| minichromosome maintenance complex component 7 isoform 1 [Homo sapiens] [NCBI NR] gi\|20981696\|sp\|P33993.4\|MCM7_HUMAN RecName: Full=DNA replication licensing factor MCM7; AltName: Full=CDC47 homolog; AltName: Full=P1.1-MCM3 [NCBI NR] gi\|15426528\|gb\|AAH13375.1\| Minichromosome maintenance complex component 7 [Homo sapiens] [NCBI NR] gi\|119597005\|gb\|EAW76599.1\| MCM7 minichromosome maintenance deficient 7 (S. cerevisiae), isoform CRA_b [Homo sapiens] [NCBI NR] minichromosome maintenance complex component 7 [HGNC (HUGO)] DNA replication licensing factor MCM7 OS=Homo sapiens GN=MCM7 PE=1 SV=4 [Swiss-Prot] Splice isoform 1 of P33993 [hmr_yeast5_DM3-1_pombe.fasta] minichromosome maintenance protein 7 isoform 1; DNA replication licensing factor MCM7; homolog of S. cerevisiae Cdc47 [HMR_022704.fasta] minichromosome maintenance protein 7 isoform 1; DNA replication licensing factor MCM7; homolog of S. cerevisiae Cdc47; minichromosome maintenance deficient (S. cerevisiae) 7 [071204_hmrz_cont.fasta] minichromosome maintenance protein 7 isoform 1 [Homo sapiens]gi\|51094603\|gb\|EAL23855.1\| MCM7 minichromosome maintenance deficient 7 (S. cerevisiae) [Homo sapiens]gi\|15426528\|gb\|AAH13375.1\| Minichromosome maintenance protein 7, isoform 1 [Homo sapiens]g [nrdb_11152004_Chlamydomonas] DNA replication licensing factor MCM7 (CDC47 homolog) (P1.1-MCM3) [Yateslab_human_na_07-28-2006_reversed.fasta] Tax_Id=9606 Splice Isoform 1 of DNA replication licensing factor MCM7 [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta] minichromosome maintenance protein 7 isoform 1 [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta] minichromosome maintenance protein 7 isoform 1; DNA replication licensing factor MCM7; homolog of S. cerevisiae Cdc47; minichromosome maintenance deficient (S. cerevisiae) 7 [Homo sapiens] [HumanGallus06162005.fasta] minichromosome maintenance protein 7 isoform 1; DNA replication licensing factor MCM7; homolog of S. cerevisiae Cdc47 [Homo sapiens] [human-NCBI-042104-rand.fasta] minichromosome maintenance complex component 7 isoform 1 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] Minichromosome maintenance complex component 7 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] MCM7 minichromosome maintenance deficient 7 (S. cerevisiae), isoform CRA_b [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] MCM7 minichromosome maintenance deficient 7 (S. cerevisiae) [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] Tax_Id=9606 Isoform 1 of DNA replication licensing factor MCM7 [EBI-IPI_human_3.23_11-02-2006_con_reversed.fasta] Tax_Id=9606 SPLICE ISOFORM 1 OF DNA REPLICATION LICENSING FACTOR MCM7 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Tax_Id=9606 Gene_Symbol=MCM7 Isoform 1 of DNA replication licensing factor MCM7 [human-ipi-250309-contam.fasta] IPI:IPI00299904.3\|SWISS-PROT:P33993-1\|TREMBL:A4D2A1;B2RBA6;B3KUD7;B4DDF5\|ENSEMBL:ENSP00000307288\|REFSEQ:NP_005907\|H-INV:HIT000021814\|VEGA:OTTHUMP00000024926;OTTHUMP00000206385 Tax_Id=9606 Gene_Symbol=MCM7 Isoform 1 of DNA replication licensing factor MCM7 [ipi.HUMAN.fasta.20090807] [human_BMb_040710_contam.fasta] Tax_Id=9606 Gene_Symbol=MCM7 Isoform 1 of DNA replication licensing factor MCM7 ENSG00000166508 IPI00299904 IPI00376143 IPI00219740 IPI00387004 [drosphohumanreversed.fasta] P33993;A4D2A1;Q15076;Q96D34;Q96GL1; RecName: Full=DNA replication licensing factor MCM7; AltName: Full=CDC47 homolog; AltName: Full=P1.1-MCM3; [UniProt_Human_2010_06_06-01-2010_reversed.fasta] Isoform 1 of DNA replication licensing factor MCM7 OS=Homo sapiens GN=MCM7 [011711_HMR.fasta] IPI:IPI00299904.3\|SWISS-PROT:P33993-1\|TREMBL:B2RBA6;B3KUD7;B4DDF5;C6EMX8\|ENSEMBL:ENSP00000307288\|REFSEQ:NP_005907\|H-INV:HIT000021814\|VEGA:OTTHUMP00000024926;OTTHUMP00000206385 Tax_Id=9606 Gene_Symbol=MCM7 Isoform 1 of DNA replication licensing factor MCM7 [ipi.HUMAN.fasta.20100406] GeneSymbol=MCM7 Synonyms=CDC47\|MCM2\|P1.1-MCM3\|P1CDC47\|P85MCM\|PNAS146 DNA replication licensing factor MCM7 isoform 1 [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta] IPI:IPI00299904.3\|SWISS-PROT:P33993-1\|TREMBL:B2RBA6;C6EMX8\|ENSEMBL:ENSP00000307288\|REFSEQ:NP_005907\|VEGA:OTTHUMP00000206385 Tax_Id=9606 Gene_Symbol=MCM7 Isoform 1 of DNA replication licensing factor MCM7 [ipi.HUMAN.20110912.fasta] DNA replication licensing factor MCM7 GN=MCM7 [Doctor+uniprot-HUMAN-120911.fasta]
Organism:	Homo sapiens
Length:	719 amino acids
Gene Ontology:
Cellular Component:	NONE FOUND
Biological Process:	NONE FOUND
Molecular Function:	NONE FOUND

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALKDYALEK EKVKKFLQEF YQDDELGKKQ FKYGNQLVRL AHREQVALYV DLDDVAEDDP  60
   61 ELVDSICENA RRYAKLFADA VQELLPQYKE REVVNKDVLD VYIEHRLMME QRSRDPGMVR 120
  121 SPQNQYPAEL MRRFELYFQG PSSNKPRVIR EVRADSVGKL VTVRGIVTRV SEVKPKMVVA 180
  181 TYTCDQCGAE TYQPIQSPTF MPLIMCPSQE CQTNRSGGRL YLQTRGSRFI KFQEMKMQEH 240
  241 SDQVPVGNIP RSITVLVEGE NTRIAQPGDH VSVTGIFLPI LRTGFRQVVQ GLLSETYLEA 300
  301 HRIVKMNKSE DDESGAGELT REELRQIAEE DFYEKLAASI APEIYGHEDV KKALLLLLVG 360
  361 GVDQSPRGMK IRGNINICLM GDPGVAKSQL LSYIDRLAPR SQYTTGRGSS GVGLTAAVLR 420
  421 DSVSGELTLE GGALVLADQG VCCIDEFDKM AEADRTAIHE VMEQQTISIA KAGILTTLNA 480
  481 RCSILAAANP AYGRYNPRRS LEQNIQLPAA LLSRFDLLWL IQDRPDRDND LRLAQHITYV 540
  541 HQHSRQPPSQ FEPLDMKLMR RYIAMCREKQ PMVPESLADY ITAAYVEMRR EAWASKDATY 600
  601 TSARTLLAIL RLSTALARLR MVDVVEKEDV NEAIRLMEMS KDSLLGDKGQ TARTQRPADV 660
  661 IFATVRELVS GGRSVRFSEA EQRCVSRGFT PAQFQAALDE YEELNVWQVN ASRTRITFV

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

No functions predicted.

Term	Confidence	Notes
DNA clamp loader activity	4.91429252297969	bayes_pls_golite062009
protein-DNA loading ATPase activity	4.80695929076807	bayes_pls_golite062009
DNA-dependent ATPase activity	2.72462789867829	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	2.66107861968804	bayes_pls_golite062009
binding	2.64537357529343	bayes_pls_golite062009
nucleic acid binding	2.51683451033161	bayes_pls_golite062009
DNA helicase activity	2.2817164193758	bayes_pls_golite062009
pyrophosphatase activity	2.13284212711072	bayes_pls_golite062009
DNA binding	2.12258000781149	bayes_pls_golite062009
transcription regulator activity	2.09345198747025	bayes_pls_golite062009
telomeric DNA binding	2.0142766759353	bayes_pls_golite062009
ATP-dependent DNA helicase activity	1.88455339138556	bayes_pls_golite062009
helicase activity	1.70242731830224	bayes_pls_golite062009
microtubule motor activity	1.6537049553461	bayes_pls_golite062009
RNA helicase activity	1.63960194106079	bayes_pls_golite062009
DNA replication origin binding	1.62491387774159	bayes_pls_golite062009
ATP-dependent RNA helicase activity	1.61735400124552	bayes_pls_golite062009
RNA-dependent ATPase activity	1.60404584546501	bayes_pls_golite062009
ribonucleotide binding	1.53142082854758	bayes_pls_golite062009
purine nucleotide binding	1.52938239070386	bayes_pls_golite062009
purine ribonucleotide binding	1.52887308780164	bayes_pls_golite062009
nucleotide binding	1.52746968836881	bayes_pls_golite062009
structural constituent of ribosome	1.47858140861683	bayes_pls_golite062009
ATP binding	1.23942044024113	bayes_pls_golite062009
protein binding	1.22129154759482	bayes_pls_golite062009
adenyl ribonucleotide binding	1.21044170258803	bayes_pls_golite062009
structure-specific DNA binding	1.20315703345493	bayes_pls_golite062009
adenyl nucleotide binding	1.19481945569892	bayes_pls_golite062009
ATP-dependent helicase activity	1.19311444180077	bayes_pls_golite062009
purine NTP-dependent helicase activity	1.19311444180077	bayes_pls_golite062009
motor activity	1.14667913749579	bayes_pls_golite062009
lysine N-acetyltransferase activity	1.05990253628867	bayes_pls_golite062009
histone acetyltransferase activity	1.05990253628867	bayes_pls_golite062009
double-stranded DNA binding	1.05408274676326	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
DNA-directed DNA polymerase activity	0.971476020912368	bayes_pls_golite062009
DNA polymerase activity	0.928091843881235	bayes_pls_golite062009
transcription activator activity	0.889929694023098	bayes_pls_golite062009
transcription factor activity	0.887108427603557	bayes_pls_golite062009
structural molecule activity	0.86514677273731	bayes_pls_golite062009
transcription repressor activity	0.862685397469217	bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism	0.8469248456592	bayes_pls_golite062009
single-stranded telomeric DNA binding	0.700780808446722	bayes_pls_golite062009
kinase activity	0.641541011250583	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.584453361662212	bayes_pls_golite062009
sequence-specific DNA binding	0.543891899378373	bayes_pls_golite062009
cytoskeletal protein binding	0.500462538667228	bayes_pls_golite062009
single-stranded DNA binding	0.406600732518248	bayes_pls_golite062009
protein kinase activity	0.351308564667977	bayes_pls_golite062009
translation regulator activity	0.29096092258568	bayes_pls_golite062009
translation factor activity, nucleic acid binding	0.274994961137851	bayes_pls_golite062009
four-way junction helicase activity	0.26252931460003	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.243902356228423	bayes_pls_golite062009
exodeoxyribonuclease V activity	0.185603938981231	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	0.156278588350022	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.147579541298736	bayes_pls_golite062009
mismatched DNA binding	0.13366911641814	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.113504049290503	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.111293884322157	bayes_pls_golite062009
3'-5' DNA helicase activity	0.0769112340058804	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	0.0223627159838333	bayes_pls_golite062009
actin binding	0.00482938540552702	bayes_pls_golite062009

No functions predicted.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..172]	PSI-BLAST	35.39794	DNA replication initiator (cdc21/cdc54) N-terminal domain
2	View Details	[173..590]	PSI-BLAST	33.69897	N-terminal, ClpS-binding domain of ClpA, an Hsp100 chaperone; ClpA, an Hsp100 chaperone, AAA+ modules
3	View Details	[591..719]	PSI-BLAST	47.69897	Crystal structure of a sigma54-activator suggests the mechanism for the conformational switch necessary for sigma54 binding

Protein Overview: MCM7

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: