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Protein Overview: FCERA_MOUSE, FCE...

General Information:
Name(s) found: FCERA_MOUSE [Swiss-Prot]
FCEA_MOUSE [Swiss-Prot]
Description(s) found:
Found 28 descriptions.
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  • High affinity immunoglobulin epsilon receptor subunit alpha OS=Mus musculus GN=Fcer1a PE=2 SV=1 [Swiss-Prot]
  • (P20489) High affinity immunoglobulin epsilon receptor alpha-subunit precursor (FCERI) (IGE FC receptor, alpha-subunit) (FC-epsilon RI-alpha) [Swiss-Prot]
    • Organism: Mus musculus
    Length: 250 amino acids

    Gene Ontology:
    Cellular Component: integral to plasma membrane [IDA]
    membrane [IEA]
    membrane raft [TAS]
    integral to membrane [IEA]
    external side of plasma membrane [IDA]
    plasma membrane [IEA]
    Biological Process: positive regulation of calcium-mediated signaling [IDA]
    activation of MAPK activity [IDA]
    positive regulation of mast cell degranulation [IDA]
    leukotriene biosynthetic process [IDA]
    serotonin secretion [IDA][IMP]
    signal transduction [IDA]
    positive regulation of type I hypersensitivity [IMP]
    positive regulation of interleukin-3 biosynthetic process [IDA]
    activation of JUN kinase activity [IDA]
    cell surface receptor linked signaling pathway [IDA][IMP]
    positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process [IDA]
    positive regulation of peptidyl-tyrosine phosphorylation [IDA]
    Molecular Function: IgE binding [IDA][IMP]
    receptor activity [IEA]
    IgE receptor activity [IDA][IMP]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVTGRSAQLC LALLFMSLDV ILTATEKSVL TLDPPWIRIF TGEKVTLSCY GNNHLQMNST  60
   61 TKWIHNGTVS EVNSSHLVIV SATVQDSGKY ICQKQGLFKS KPVYLNVTQD WLLLQTSADM 120
  121 ILVHGSFDIR CHGWKNWNVR KVIYYRNDHA FNYSYESPVS IREATLNDSG TYHCKGYLRQ 180
  181 VEYESDKFRI AVVKAYKCKY YWLQLIFPLL VAILFAVDTG LLLSTEEQFK SVLEIQKTGK 240
  241 YKKVETELLT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..197] PSI-BLAST 33.522879 IgE high affinity receptor alpha subunit
    2 View Details [198..250] PSI-BLAST 4.0 Immunoglobulin heavy chain variable domain, VH; Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • peptide antigen binding
    		•  6.88465387482513 bayes_pls_golite062009
  • antigen binding
    		•  5.9176308851452 bayes_pls_golite062009
  • IgG binding
    		•  5.54284971652486 bayes_pls_golite062009
  • immunoglobulin receptor activity
    		•  5.14639405668399 bayes_pls_golite062009
  • IgG receptor activity
    		•  4.31132706608247 bayes_pls_golite062009
  • immunoglobulin binding
    		•  4.25751339132775 bayes_pls_golite062009
  • IgE receptor activity
    		•  4.06997198366234 bayes_pls_golite062009
  • IgE binding
    		•  4.06997198366234 bayes_pls_golite062009
  • receptor activity
    		•  4.00123250685257 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  3.81769911097805 bayes_pls_golite062009
  • binding
    		•  3.17641566810715 bayes_pls_golite062009
  • signal transducer activity
    		•  3.10913345555941 bayes_pls_golite062009
  • molecular transducer activity
    		•  3.10913345555941 bayes_pls_golite062009
  • olfactory receptor activity
    		•  2.99663023419676 bayes_pls_golite062009
  • protein binding
    		•  2.22855404705168 bayes_pls_golite062009
  • fibroblast growth factor 1 binding
    		•  2.19552124689493 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.73930160869963 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.69371027304398 bayes_pls_golite062009
  • DNA binding
    		•  1.61538654384419 bayes_pls_golite062009
  • growth factor binding
    		•  1.60826091835429 bayes_pls_golite062009
  • high affinity IgE receptor activity
    		•  1.55195842406798 bayes_pls_golite062009
  • protein kinase activity
    		•  1.36635494500222 bayes_pls_golite062009
  • fibroblast growth factor binding
    		•  1.27793818082552 bayes_pls_golite062009
  • G-protein coupled receptor activity
    		•  1.02428106476324 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.02286631988334 bayes_pls_golite062009
  • transcription activator activity
    		•  0.935229148203189 bayes_pls_golite062009
  • kinase activity
    		•  0.929878054374821 bayes_pls_golite062009
  • transcription factor activity
    		•  0.91425111006527 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.878595022643164 bayes_pls_golite062009
  • protein complex binding
    		•  0.83543827718565 bayes_pls_golite062009
  • peptide binding
    		•  0.729048089532569 bayes_pls_golite062009
  • coreceptor activity
    		•  0.661209696849389 bayes_pls_golite062009
  • receptor binding
    		•  0.632627479346393 bayes_pls_golite062009
  • cytokine binding
    		•  0.631436442105379 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.564762108830441 bayes_pls_golite062009
  • cell surface binding
    		•  0.477483205369537 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.447829399094714 bayes_pls_golite062009
  • cytokine receptor activity
    		•  0.34165331857492 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  0.318890055375093 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  0.28309679787333 bayes_pls_golite062009
  • MHC class II receptor activity
    		•  0.251167772391909 bayes_pls_golite062009
  • transferase activity
    		•  0.053007146193305 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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