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Protein Overview: FLC1

General Information:
Name(s) found: FLC1 / YPL221W [SGD]
Description(s) found:
Found 23 descriptions.
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  • Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 793 amino acids

    Gene Ontology:
    Cellular Component: cellular bud neck [IDALink to PubMed article]
    endoplasmic reticulum [IDALink to PubMed article]
    fungal-type vacuole [IDALink to PubMed article]
    Biological Process: fungal-type cell wall biogenesis [IMPLink to PubMed article]
    FAD transport [IMPLink to PubMed article]
    protein folding [IMPLink to PubMed article]
    Molecular Function: FAD transmembrane transporter activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQVLVTLWCL ICTCLVLPVA AKKRTLTASS LVTCMENSQL SANSFDVSFS PDDRSLHYDL  60
   61 DMTTQIDSYI YAYVDVYAYG FKIITENFDV CSMGWKQFCP VHPGNIQIDS IEYIAQKYVK 120
  121 MIPGIAYQVP DIDAYVRLNI YNNVSENLAC IQVFFSNGKT VSQIGVKWVT AVIAGIGLLT 180
  181 SAVLSTFGNS TAASHISANT MSLFLYFQSV AVVAMQHVDS VPPIAAAWSE NLAWSMGLIR 240
  241 ITFMQKIFRW YVEATGGSAS LYLTATTMSV LTQRGLDYLK NTSVYKRAEN VLYGNSNTLI 300
  301 FRGIKRMGYR MKIENTAIVC TGFTFFVLCG YFLAGFIMAC KYSIELCIRC GWMRSDRFYQ 360
  361 FRKNWRSVLK GSLLRYIYIG FTQLTILSFW EFTERDSAGV IVIACLFIVL SCGLMAWAAY 420
  421 RTIFFASKSV EMYNNPAALL YGDEYVLNKY GFFYTMFNAK HYWWNALLTT YILVKALFVG 480
  481 FAQASGKTQA LAIFIIDLAY FVAIIRYKPY LDRPTNIVNI FICTVTLVNS FLFMFFSNLF 540
  541 NQKYAVSAIM GWVFFIMNAA FSLLLLLMIL AFTTIILFSK NPDSRFKPAK DDRASFQKHA 600
  601 IPHEGALNKS VANELMALGN VAKDHTENWE YELKSQEGKS EDNLFGVEYD DEKTGTNSEN 660
  661 AESSSKETTR PTFSEKVLRS LSIKRNKSKL GSFKRSAPDK ITQQEVSPDR ASSSPNSKSY 720
  721 PGVSHTRQES EANNGLINAY EDEQFSLMEP SILEDAASST QMHAMPARDL SLSSVANAQD 780
  781 VTKKANILDP DYL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) FLC1 FLC2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data FLC1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..216] MSA 1.012955 View MSA. No confident structure predictions are available.
    2 View Details [217..294] deduced N/A No confident structure predictions are available.
    3 View Details [295..601] MSA 5.021993 View MSA. No confident structure predictions are available.
    4 View Details [602..793] MSA 1.00894 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • voltage-gated cation channel activity
    		•  2.66540214971227 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  2.66283817406605 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  2.65916906094646 bayes_pls_golite062009
  • channel activity
    		•  2.65916906094646 bayes_pls_golite062009
  • cation channel activity
    		•  2.62747969257897 bayes_pls_golite062009
  • potassium channel activity
    		•  2.61371256192732 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  2.60719363833593 bayes_pls_golite062009
  • ion channel activity
    		•  2.60082350471123 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  2.58448165457823 bayes_pls_golite062009
  • voltage-gated potassium channel activity
    		•  2.57450407680312 bayes_pls_golite062009
  • gated channel activity
    		•  2.51455369837435 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  2.48447488950861 bayes_pls_golite062009
  • transporter activity
    		•  2.35657262831396 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.25147059981728 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  2.22751878261824 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.14804562881998 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.08500207462933 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  2.07445794288256 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  2.07445794288256 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.02275538762334 bayes_pls_golite062009
  • binding
    		•  2.01341910518392 bayes_pls_golite062009
  • inward rectifier potassium channel activity
    		•  1.9397436784802 bayes_pls_golite062009
  • hydrolase activity
    		•  1.63153428386052 bayes_pls_golite062009
  • protein binding
    		•  1.42362322632607 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.0852462445742306 bayes_pls_golite062009
  • signal transducer activity
    		•  0.0433671294560209 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.0433671294560209 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle