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View Structure Prediction Details

Protein: FLC1
Organism: Saccharomyces cerevisiae
Length: 793 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FLC1.

Description E-value Query
Range
Subject
Range
FLC1 - Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wa...
FLC1_YEAST - Flavin carrier protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FLC1 PE=1 SV=1
0.0 [1..793] [1..793]
gi|85104026 - gi|85104026|ref|XP_961648.1| hypothetical protein ( (AF294883) calcium-related spray protein [Neuros...
gi|32412097, gi|... - gi|9945012|gb|AAG03077.1| calcium-related spray protein [Neurospora crassa], gi|32412097|ref|XP_3265...
0.0 [6..600] [387..1008]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [6..600] [9..630]
PKD2_SCHPO - TRP-like ion channel pkd2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=pkd2 PE=1 SV=1
pkd2 - TRP-like ion channel
0.0 [6..601] [8..610]

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Predicted Domain #1
Region A:
Residues: [1-216]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQVLVTLWCL ICTCLVLPVA AKKRTLTASS LVTCMENSQL SANSFDVSFS PDDRSLHYDL  60
   61 DMTTQIDSYI YAYVDVYAYG FKIITENFDV CSMGWKQFCP VHPGNIQIDS IEYIAQKYVK 120
  121 MIPGIAYQVP DIDAYVRLNI YNNVSENLAC IQVFFSNGKT VSQIGVKWVT AVIAGIGLLT 180
  181 SAVLSTFGNS TAASHISANT MSLFLYFQSV AVVAMQ

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
voltage-gated cation channel activity 2.66540214971227 bayes_pls_golite062009
substrate-specific channel activity 2.66283817406605 bayes_pls_golite062009
passive transmembrane transporter activity 2.65916906094646 bayes_pls_golite062009
channel activity 2.65916906094646 bayes_pls_golite062009
cation channel activity 2.62747969257897 bayes_pls_golite062009
potassium channel activity 2.61371256192732 bayes_pls_golite062009
voltage-gated ion channel activity 2.60719363833593 bayes_pls_golite062009
ion channel activity 2.60082350471123 bayes_pls_golite062009
voltage-gated channel activity 2.58448165457823 bayes_pls_golite062009
voltage-gated potassium channel activity 2.57450407680312 bayes_pls_golite062009
gated channel activity 2.51455369837435 bayes_pls_golite062009
metal ion transmembrane transporter activity 2.48447488950861 bayes_pls_golite062009
transporter activity 2.35657262831396 bayes_pls_golite062009
transmembrane transporter activity 2.25147059981728 bayes_pls_golite062009
substrate-specific transporter activity 2.22751878261824 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 2.14804562881998 bayes_pls_golite062009
ion transmembrane transporter activity 2.08500207462933 bayes_pls_golite062009
ligand-gated ion channel activity 2.07445794288256 bayes_pls_golite062009
ligand-gated channel activity 2.07445794288256 bayes_pls_golite062009
cation transmembrane transporter activity 2.02275538762334 bayes_pls_golite062009
binding 2.01341910518392 bayes_pls_golite062009
inward rectifier potassium channel activity 1.9397436784802 bayes_pls_golite062009
hydrolase activity 1.63153428386052 bayes_pls_golite062009
protein binding 1.42362322632607 bayes_pls_golite062009
cytoskeletal protein binding 0.0852462445742306 bayes_pls_golite062009
signal transducer activity 0.0433671294560209 bayes_pls_golite062009
molecular transducer activity 0.0433671294560209 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [217-294]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HVDSVPPIAA AWSENLAWSM GLIRITFMQK IFRWYVEATG GSASLYLTAT TMSVLTQRGL  60
   61 DYLKNTSVYK RAENVLYG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [295-601]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSNTLIFRGI KRMGYRMKIE NTAIVCTGFT FFVLCGYFLA GFIMACKYSI ELCIRCGWMR  60
   61 SDRFYQFRKN WRSVLKGSLL RYIYIGFTQL TILSFWEFTE RDSAGVIVIA CLFIVLSCGL 120
  121 MAWAAYRTIF FASKSVEMYN NPAALLYGDE YVLNKYGFFY TMFNAKHYWW NALLTTYILV 180
  181 KALFVGFAQA SGKTQALAIF IIDLAYFVAI IRYKPYLDRP TNIVNIFICT VTLVNSFLFM 240
  241 FFSNLFNQKY AVSAIMGWVF FIMNAAFSLL LLLMILAFTT IILFSKNPDS RFKPAKDDRA 300
  301 SFQKHAI

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [602-793]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PHEGALNKSV ANELMALGNV AKDHTENWEY ELKSQEGKSE DNLFGVEYDD EKTGTNSENA  60
   61 ESSSKETTRP TFSEKVLRSL SIKRNKSKLG SFKRSAPDKI TQQEVSPDRA SSSPNSKSYP 120
  121 GVSHTRQESE ANNGLINAYE DEQFSLMEPS ILEDAASSTQ MHAMPARDLS LSSVANAQDV 180
  181 TKKANILDPD YL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle