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Protein Overview: PXA1

General Information:
Name(s) found: PXA1 / YPL147W [SGD]
Description(s) found:
Found 27 descriptions.
SHOW ALL
  • Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter and ALD-related proteins [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 870 amino acids

    Gene Ontology:
    Cellular Component: integral to peroxisomal membrane [IDALink to PubMed article]
    Biological Process: fatty acid transport [IMPLink to PubMed article]
    Molecular Function: ATPase activity, coupled to transmembrane movement of substances [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTTLAAPAK LKSLLLNLHT HCIGLHVNDV TPKVYFKLLI RHLLQISRSN AAHPKLRRRA  60
   61 QILLVSLFLS GVTLFSGVTY STFKIILKCY KFYKFPWKRR NRRPLIRRTR SQMQLDSGAR 120
  121 IMYIPEVELV DRQSPDDNKF MNATDKKKRK RIFIPPKDND VYEHDKFLFK NVELERAKNS 180
  181 QLFYSKFLNQ MNVLSKILIP TVFDKNFLLL TAQIFFLVMR TWLSLFVAKL DGQIVKNIIA 240
  241 GRGRSFLWDL GCWFLIAVPA SYTNSAIKLL QRKLSLNFRV NLTRYIHDMY LDKRLTFYKL 300
  301 IFDAKASNSV IKNIDNSITN DVAKFCDATC SVFANIAKPV IDLIFFSVYL RDNLGTVGVA 360
  361 GIFVNYFITG FILRKYTPPL GKLAGERSAS DGDYYNYHLN MINNSEEIAF YQGTAVERTK 420
  421 VKELYDVLME KMLLVDKVKF GYNMLEDYVL KYTWSGLGYV FASIPIVMST LATGINSEEK 480
  481 NMKEFIVNKR LMLSLADAGS RLMHSIKDIS QLTGYTNRIF TLLSVLHRVH SLNFNYGAVP 540
  541 SILSIRTEDA SRNSNLLPTT DNSQDAIRGT IQRNFNGIRL ENIDVIIPSV RASEGIKLIN 600
  601 KLTFQIPLHI DPITSKSNSI QDLSKANDIK LPFLQGSGSS LLILGPNGCG KSSIQRIIAE 660
  661 IWPVYNKNGL LSIPSENNIF FIPQKPYFSR GGTLRDQIIY PMSSDEFFDR GFRDKELVQI 720
  721 LVEVKLDYLL KRGVGLTYLD AIADWKDLLS GGEKQRVNFA RIMFHKPLYV VLDEATNAIS 780
  781 VDMEDYLFNL LKRYRFNFIS ISQRPTLIKY HEMLLEIGEN RDGKWQLQAV GTDEAITSID 840
  841 NEIEELERKL ERVKGWEDER TKLREKLEII

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) PXA1 PXA2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #14 Mitotic Prep2-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen HMT1 PXA1 1 Unpublished Fields Lab Data
    View Screen CAB2 PXA1 1 Unpublished Fields Lab Data
    View Screen PRP16 PXA1 1 Unpublished Fields Lab Data
    View Screen SPO21 PXA1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..302] deduced N/A No confident structure predictions are available.
    2 View Details [303..396]
    [415..588]    		 PSI-BLAST 179.0 MsbA
    3 View Details [397..414]
    [589..870]    		 PSI-BLAST 179.0 MsbA

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • ATPase activity, coupled to transmembrane movement of substances
    		•  5.57844095962502 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  5.57813579764186 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  5.57813579764186 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  5.5689620139321 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  5.55992639965745 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  5.50005167063544 bayes_pls_golite062009
  • lipid transporter activity
    		•  5.43964691043504 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  4.98276715440477 bayes_pls_golite062009
  • ATPase activity
    		•  4.69795387297193 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  4.45923622153365 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  4.39781350157199 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  4.38133275795019 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  4.38085303582726 bayes_pls_golite062009
  • transporter activity
    		•  3.71239480053329 bayes_pls_golite062009
  • hydrolase activity
    		•  3.14498892233323 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  3.13960906549884 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  3.1318898376276 bayes_pls_golite062009
  • ATP binding
    		•  3.01346604299372 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  2.96271391116269 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  2.91131545957759 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  2.70262534541085 bayes_pls_golite062009
  • ribonucleotide binding
    		•  2.70178191749524 bayes_pls_golite062009
  • purine nucleotide binding
    		•  2.6583477492092 bayes_pls_golite062009
  • nucleotide binding
    		•  2.62374702628143 bayes_pls_golite062009
  • binding
    		•  1.69327117652379 bayes_pls_golite062009
  • peptide-transporting ATPase activity
    		•  1.37783759788533 bayes_pls_golite062009
  • peptide transporter activity
    		•  1.19353064661766 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.08692822631118 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.977237423302079 bayes_pls_golite062009
  • motor activity
    		•  0.87979065815418 bayes_pls_golite062009
  • GTPase activity
    		•  0.83849854735032 bayes_pls_golite062009
  • cholesterol transporter activity
    		•  0.644421039250979 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.557919489256916 bayes_pls_golite062009
  • sterol transporter activity
    		•  0.51525091036229 bayes_pls_golite062009
  • drug transmembrane transporter activity
    		•  0.38711726712063 bayes_pls_golite062009
  • protein binding
    		•  0.378225828131122 bayes_pls_golite062009
  • catalytic activity
    		•  0.368034275052766 bayes_pls_golite062009
  • fatty acid transporter activity
    		•  0.278494397068437 bayes_pls_golite062009
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
    		•  0.213018989352421 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  0.123304946374679 bayes_pls_golite062009
  • microtubule motor activity
    		•  0.11674780318211 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  0.0775601177068852 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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