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Protein Overview: HST2

General Information:
Name(s) found: HST2 / YPL015C [SGD]
Description(s) found:
Found 28 descriptions.
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  • Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 357 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: chromatin silencing at rDNA [IMPLink to PubMed articleLink to PubMed article]
    negative regulation of chromatin silencing at telomere [IMPLink to PubMed article]
    negative regulation of mitotic recombination [IGILink to PubMed article][IMPLink to PubMed article]
    chronological cell aging [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: NAD-dependent histone deacetylase activity [IDALink to PubMed articleLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVSTASTEM SVRKIAAHMK SNPNAKVIFM VGAGISTSCG IPDFRSPGTG LYHNLARLKL  60
   61 PYPEAVFDVD FFQSDPLPFY TLAKELYPGN FRPSKFHYLL KLFQDKDVLK RVYTQNIDTL 120
  121 ERQAGVKDDL IIEAHGSFAH CHCIGCGKVY PPQVFKSKLA EHPIKDFVKC DVCGELVKPA 180
  181 IVFFGEDLPD SFSETWLNDS EWLREKITTS GKHPQQPLVI VVGTSLAVYP FASLPEEIPR 240
  241 KVKRVLCNLE TVGDFKANKR PTDLIVHQYS DEFAEQLVEE LGWQEDFEKI LTAQGGMGDN 300
  301 SKEQLLEIVH DLENLSLDQS EHESADKKDK KLQRLNGHDS DEDGASNSSS SQKAAKE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RBA50 No Comments Hazbun TR, et al. (2003)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data HST2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..43]
    [88..137]
    [189..357]    		 PSI-BLAST 662.9897 Sirt2 histone deacetylase
    2 View Details [44..87]
    [138..188]    		 PSI-BLAST 662.9897 Sirt2 histone deacetylase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein deacetylase activity
    		•  9.15022242957651 bayes_pls_golite062009
  • histone deacetylase activity
    		•  9.04876491350231 bayes_pls_golite062009
  • NAD-dependent protein deacetylase activity
    		•  8.13038616303736 bayes_pls_golite062009
  • NAD-dependent histone deacetylase activity
    		•  8.13038616303736 bayes_pls_golite062009
  • deacetylase activity
    		•  8.11496387956068 bayes_pls_golite062009
  • histone deacetylase activity (H3-K14 specific)
    		•  6.02509672218091 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
    		•  5.83127897351395 bayes_pls_golite062009
  • NAD-dependent histone deacetylase activity (H3-K9 specific)
    		•  5.29340754009793 bayes_pls_golite062009
  • NAD-dependent histone deacetylase activity (H3-K14 specific)
    		•  5.29340754009793 bayes_pls_golite062009
  • NAD-dependent histone deacetylase activity (H4-K16 specific)
    		•  4.51070381823692 bayes_pls_golite062009
  • histone deacetylase activity (H3-K9 specific)
    		•  3.4896257195243 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.9155913558118 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    		•  2.82468859281133 bayes_pls_golite062009
  • DNA binding
    		•  2.43141001866996 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.41433477472968 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.24657784428979 bayes_pls_golite062009
  • binding
    		•  2.06552694538163 bayes_pls_golite062009
  • histone binding
    		•  1.71445510915336 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.64212790017753 bayes_pls_golite062009
  • protein binding
    		•  1.52593340148652 bayes_pls_golite062009
  • nucleosome binding
    		•  1.5125174755597 bayes_pls_golite062009
  • hydrolase activity
    		•  1.43067365161346 bayes_pls_golite062009
  • transcription factor activity
    		•  1.30143289828088 bayes_pls_golite062009
  • transcription factor binding
    		•  1.14766678956419 bayes_pls_golite062009
  • tubulin deacetylase activity
    		•  1.11434618720209 bayes_pls_golite062009
  • catalytic activity
    		•  0.739210399081789 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.54005617175343 bayes_pls_golite062009
  • transferase activity
    		•  0.483523935618287 bayes_pls_golite062009
  • NAD+ ADP-ribosyltransferase activity
    		•  0.0099486881187274 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.77

    Source: Reynolds et al. (2008)

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    Created and Maintained by: Michael Riffle