YRC Public Data Repository - Protein Structure Prediction

Protein:	HST2
Organism:	Saccharomyces cerevisiae
Length:	357 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HST2.

Description	E-value	Query Range	Subject Range
HST2_YEAST - NAD-dependent protein deacetylase HST2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=H... HST2 - Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protei...	2.0E-96	[1..357]	[1..357]
gi\|170650632, gi... - gi\|170650632\|ref\|NP_001116237.1\| sirtuin 2 isoform 2 [Mus musculus], gi\|148692165\|gb\|EDL24112.1\| sir...	2.0E-83	[7..334]	[22..352]
gi\|114677035, gi... - gi\|114677041\|ref\|XP_001168346.1\| PREDICTED: sirtuin 2 isoform 7 [Pan troglodytes], gi\|114677039\|ref\|... SIR2_PONAB - NAD-dependent protein deacetylase sirtuin-2 OS=Pongo abelii GN=SIRT2 PE=2 SV=1 SIRT2_PONPY - NAD-dependent deacetylase sirtuin-2 - Pongo pygmaeus (Orangutan) gi\|158254868, gi... - gi\|5668596\|gb\|AAD45971.1\|AF095714_1 silencing information regulator 2-like protein [Homo sapiens], g... SIRT2_RAT, SIR2_RAT - (Q924Y7) NAD-dependent deacetylase sirtuin-2 (EC 3.5.1.-) (SIR2-like protein 2), (Q924Y7) NAD-depend... gi\|224487801, gi... - gi\|224487801\|dbj\|BAH24135.1\| sirtuin (silent mating type information regulation 2 homolog) 2 [synthe...	4.0E-81	[7..334]	[22..352]
HST2_SCHPO - NAD-dependent protein deacetylase hst2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=hst... hst2 - Sir2 family histone deacetylase Hst2	9.0E-80	[2..347]	[5..322]

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Predicted Domain #1

Region A:
Residues: [1-43]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVSTASTEM SVRKIAAHMK SNPNAKVIFM VGAGISTSCG IPD

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [88-137]

      1          11         21         31         41         51         
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    1 PGNFRPSKFH YLLKLFQDKD VLKRVYTQNI DTLERQAGVK DDLIIEAHGS

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [189-357]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PDSFSETWLN DSEWLREKIT TSGKHPQQPL VIVVGTSLAV YPFASLPEEI PRKVKRVLCN  60
   61 LETVGDFKAN KRPTDLIVHQ YSDEFAEQLV EELGWQEDFE KILTAQGGMG DNSKEQLLEI 120
  121 VHDLENLSLD QSEHESADKK DKKLQRLNGH DSDEDGASNS SSSQKAAKE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	662.9897
Match:	1j8fA_
Description:	Sirt2 histone deacetylase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein deacetylase activity	9.15022242957651	bayes_pls_golite062009
histone deacetylase activity	9.04876491350231	bayes_pls_golite062009
NAD-dependent protein deacetylase activity	8.13038616303736	bayes_pls_golite062009
NAD-dependent histone deacetylase activity	8.13038616303736	bayes_pls_golite062009
deacetylase activity	8.11496387956068	bayes_pls_golite062009
histone deacetylase activity (H3-K14 specific)	6.02509672218091	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	5.83127897351395	bayes_pls_golite062009
NAD-dependent histone deacetylase activity (H3-K9 specific)	5.29340754009793	bayes_pls_golite062009
NAD-dependent histone deacetylase activity (H3-K14 specific)	5.29340754009793	bayes_pls_golite062009
NAD-dependent histone deacetylase activity (H4-K16 specific)	4.51070381823692	bayes_pls_golite062009
histone deacetylase activity (H3-K9 specific)	3.4896257195243	bayes_pls_golite062009
transcription regulator activity	2.9155913558118	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	2.82468859281133	bayes_pls_golite062009
DNA binding	2.43141001866996	bayes_pls_golite062009
nucleic acid binding	2.41433477472968	bayes_pls_golite062009
transcription repressor activity	2.24657784428979	bayes_pls_golite062009
binding	2.06552694538163	bayes_pls_golite062009
histone binding	1.71445510915336	bayes_pls_golite062009
transcription corepressor activity	1.64212790017753	bayes_pls_golite062009
protein binding	1.52593340148652	bayes_pls_golite062009
nucleosome binding	1.5125174755597	bayes_pls_golite062009
hydrolase activity	1.43067365161346	bayes_pls_golite062009
transcription factor activity	1.30143289828088	bayes_pls_golite062009
transcription factor binding	1.14766678956419	bayes_pls_golite062009
tubulin deacetylase activity	1.11434618720209	bayes_pls_golite062009
catalytic activity	0.739210399081789	bayes_pls_golite062009
transcription cofactor activity	0.54005617175343	bayes_pls_golite062009
transferase activity	0.483523935618287	bayes_pls_golite062009
NAD+ ADP-ribosyltransferase activity	0.0099486881187274	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [44-87]

      1          11         21         31         41         51         
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    1 FRSPGTGLYH NLARLKLPYP EAVFDVDFFQ SDPLPFYTLA KELY

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [138-188]

      1          11         21         31         41         51         
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    1 FAHCHCIGCG KVYPPQVFKS KLAEHPIKDF VKCDVCGELV KPAIVFFGED L

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	662.9897
Match:	1j8fA_
Description:	Sirt2 histone deacetylase
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: