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Protein Overview: ULA1

General Information:
Name(s) found: ULA1 / YPL003W [SGD]
Description(s) found:
Found 28 descriptions.
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  • Protein that acts together with Uba3p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 462 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: protein neddylation [IDALink to PubMed article][IMPLink to PubMed article][ISSLink to PubMed articleLink to PubMed article]
    Molecular Function: NEDD8 activating enzyme activity [IDALink to PubMed article][IMPLink to PubMed article][ISSLink to PubMed articleLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MERYDRQLRL WGALGQDSLN RSRVCVVGPA TPLLQEVFKN LVLAGISSLT WLKVECAVQS  60
   61 GSLFLAELKK DLEPLASKQL EYEENDLRKT LQQPQYDWTR FSVVILTCIG EQTAMLDLNE 120
  121 IRRQRGTKFP PVLNTFVSGF YGYIYLVLSE THFVLQAHPD SKKYDLRLQN PWPELINYVD 180
  181 TFDLSKMDTA TFSGIPYTVL LMKCIAKLER DGNNGRITID QMKKVLDQIC LPLGNDVIYE 240
  241 PNYVEAKRYA YLACSQNDCC KELEDLLRNL EISDYGNDWH DTYNYEILTL LLTLKNIAKE 300
  301 NGELSFQPLT GTLPDMESTT ENYIRLKKLY EVKAKLDKSR VEESLARSKK IVSQDVLETF 360
  361 CSHYGEVRKI LPPKSDLLGI FSTSNALLDA LVMVQFWEQP AVTAEDKDEF IGLRVDDNYS 420
  421 VMAFFGGAVV QEAIKLITHH YVPIDNLFLY NGINNSSATY KI

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) UBA3 ULA1
    View Details Krogan NJ, et al. (2006) BUD7 RAD17 TDH2 ULA1
    View Details Gavin AC, et al. (2006) UBA3 ULA1
    View Details Gavin AC, et al. (2002) UBA3 ULA1
    View Details Ho Y, et al. (2002) PPH22 UBC12 ULA1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run VAM3 hx23: mixture in detergent (control) Investigating Vam3p, Nyv1p and their partners in trans-SNARE complex Hao Xu, et al. (2010)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..462] PSI-BLAST 126.0 No description for 2nvuA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • small protein activating enzyme activity
    		•  5.883593664369 bayes_pls_golite062009
  • NEDD8 activating enzyme activity
    		•  4.6334061288737 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  1.84216910649062 bayes_pls_golite062009
  • binding
    		•  1.66028321721112 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  1.63522698057369 bayes_pls_golite062009
  • protein binding
    		•  1.40907622346701 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.31244773198273 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  1.27535252106053 bayes_pls_golite062009
  • catalytic activity
    		•  1.22201444897049 bayes_pls_golite062009
  • NEDD8 ligase activity
    		•  1.11310449351601 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.995905648772847 bayes_pls_golite062009
  • transferase activity
    		•  0.680338489823338 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  0.302798969355962 bayes_pls_golite062009
  • URM1 activating enzyme activity
    		•  0.207228630005671 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.67

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle