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Protein Overview: UBA3

General Information:
Name(s) found: UBA3 / YPR066W [SGD]
Description(s) found:
Found 27 descriptions.
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  • Protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 299 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: protein neddylation [IDALink to PubMed article][IMPLink to PubMed article][ISSLink to PubMed article]
    Molecular Function: NEDD8 activating enzyme activity [IDALink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDCKILVLGA GGLGCEILKN LTMLSFVKQV HIVDIDTIEL TNLNRQFLFC DKDIGKPKAQ  60
   61 VAAQYVNTRF PQLEVVAHVQ DLTTLPPSFY KDFQFIISGL DAIEPRRFIN ETLVKLTLES 120
  121 NYEICIPFID GGTEGLKGHV KTIIPGITAC WECSIDTLPS QQDTVPMCTI ANNPRCIEHV 180
  181 VEYVSTIQYP DLNIESTADM EFLLEKCCER AAQFSISTEK LSTSFILGII KSIIPSVSTT 240
  241 NAMVAATCCT QMVKIYNDLI DLENGNNFTL INCSEGCFMY SFKFERLPDC TVCSNSNSN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) UBA3 ULA1
    View Details Gavin AC, et al. (2006) UBA3 ULA1
    View Details Gavin AC, et al. (2002) UBA3 ULA1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data UBA3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..103]
    [126..143]
    [234..283]    		 PSI-BLAST 756.264245 UBA3
    2 View Details [104..125]
    [144..161]
    [284..299]    		 PSI-BLAST 756.264245 UBA3
    3 View Details [162..233] PSI-BLAST 756.264245 UBA3


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.93

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle