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Protein Overview: CIN1

General Information:
Name(s) found: CIN1 / YOR349W [SGD]
Description(s) found:
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  • gi|729138|sp|P40987.1|CIN1_YEAST RecName: Full=Chromosome instability protein 1 [NCBI NR]
  • gi|6324925|ref|NP_014994.1| Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl; Cin1p [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S48235 CIN1 protein - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|563615|emb|CAA86556.1| cin1p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1420760|emb|CAA99677.1| CIN1 [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1199851|emb|CAA65036.1| 2 transmembrane spans protein; O6350 [Saccharomyces cerevisiae] [NCBI NR]
  • Chromosome instability protein 1 OS=Saccharomyces cerevisiae GN=CIN1 PE=1 SV=1 [Swiss-Prot]
  • CIN1 Chromosome segregation protein [mips]
  • Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl [SGD]
  • (P40987) CIN1 protein [4932.FASTACCERV.txt]
  • Chr XV from 989782-992826 [hmr_yeast5_DM3-1_pombe.fasta]
  • Chr XV from 989781-992825 [yeastorf3.fasta]
  • CIN1, Chr XV from 989781-992825 [yeast_orfs2]
  • CIN1 SGDID:S0005876, Chr XV from 989784-992828, Verified ORF [yeastflysequest.fasta]
  • Cin1p [Saccharomyces cerevisiae]gi|1420760|emb|CAA99677.1| CIN1 [Saccharomyces cerevisiae]gi|1199851|emb|CAA65036.1| 2 transmembrane spans protein; O6350 [Saccharomyces cerevisiae]gi|563615|emb|CAA86556.1| cin1p [Saccharomyces cerevisiae]gi|626128|pir [nrdb_11152004_Chlamydomonas]
  • CIN1 SGDID:S000005876, Chr XV from 989784-992828, Verified ORF, "Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • CIN1 SGDID:S000005876, Chr XV from 989786-992830, Verified ORF, "Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl" [yeast-contam.fasta]
  • cin1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Protein CIN1 (Chromosome instability protein 1) [nr-271106-contam.fasta]
  • 2 transmembrane spans protein; O6350 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • CIN1 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl; Cin1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • Chromosome instability protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CIN1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • CIN1 SGDID:S000005876, Chr XV from 989789-992833, Genome Release 64-1-1, Verified ORF, "Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl" [yeast-030211-contam.fasta]
  • CIN1 SGDID:S000005876, Chr XV from 989789-992833, Genome Release 64-2-1, Verified ORF, "Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl" [20141208_orf_trans.fasta]
  • YOR349W SGDID:S000005876, Chr XV from 989789-992833, Genome Release 64-1-1, Verified ORF, "Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 1014 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: post-chaperonin tubulin folding pathway [TASLink to PubMed article]
    Molecular Function: beta-tubulin binding [NASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNNIRALLDS IQSGVQTVSP EKHQQTIAAI NKFQDDPALL DTILPRCVPL LTKSFFCMSQ  60
   61 RDQKLVAELF YNLDKISHSK VLKSLDTSIF RLNEILNYLQ DRASPSSFSD VLCVYLNLSW 120
  121 LSVILLSPYA FKDKFNKTLQ VSSRFENYPI CIPPINKIKA VLYFKNFTDA FDQLPEREQA 180
  181 NVPFLNQFLK LFIQSSEKAN YYFSNENLRH LQQVALSNDG IKLLPKLFQI SFNHGSHDIL 240
  241 DAIVEFFHDH LSSNSTDTRF QLAHSFAKIA KFLHQADPAS FIELIDYTIE NTVSLLQAPC 300
  301 DSIDSNELHT SLLIIAEVAL AKILPIDLVD RVLTLIIPKT CHFQKSHFQI IKGHHIRDST 360
  361 NFIIWSVIRS NRSNSLSPQV LQSLLSHLLI NAFFDPELII RYSSFAALQE LLGRSNKSLA 420
  421 LNQNDIALIL QANWKDLPRS FEENSGLIRR LFNPENTSKS AVCVWKVFRD WSFNWNLLEN 480
  481 LHLTTMKLNI DYNLVPLIKS KLSSPALLQE VLNKAGSSVT QNCQILYLYL KLFENDVNCP 540
  541 KISEICIDIY QKKIKFQLTT QAKRQFNDNS PELFQIFVIL KYWQLTGQND FNQELFWKFV 600
  601 DIVSPQKKLN LYNEFIPIIQ QIISQCVSLN YTRIVQLIKS DNELTCRSIC HMPDQEKMCS 660
  661 LFFSQFPLLS PQSRSLLIGE LDHHWDVRIS LLPSNSYRKF RNIIINCLDD YTITQQGDVG 720
  721 RLVRIQALKL MQSHPDFLSG DCDSINPKLT RLLAEPVPEI RKLSYQLLAS ATSQITVLSD 780
  781 SSILNFRHKQ GLSEEFWKGY AVSAGAIHFT DSQLTSSIDS FIVYYRSLSP SQQLELCHDL 840
  841 IRIIPSAKQI AESRIRDRNK DPLTGGMRFD TIKFTIHCVK FWTRIMESGL VVLHPNFNFQ 900
  901 GVFAKFYNLH LLDCTTLRVS VIKFFPFLAI SCYHTMRENA DQKNLSNIIL KRLLVLVKRE 960
  961 YAATKSKFMT DQNVALQGMF QIFLELGVTR QLQALQVACQ KHELANILES DITL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) CIN1 PAC2
    View Details Gavin AC, et al. (2006) CIN1 RPL43B, RPL43A YBL104C
    View Details Gavin AC, et al. (2002) BLM10 CDC55 CIN1 ERG13 GUS1 HHF1, HHF2 HOS2 HOS4 IML1 KAP95 KEL1 LTE1 MYO5 PFK1 PPH21 PPH22 PRE1 PRE10 PRE2 PRE4 PRE5 PRE6 PRE7 PRE8 PRE9 PUP1 PUP2 PUP3 RRD2 RTS1 RTS3 SCL1 SET3 SIF2 SNT1 SRP1 TDH2 TDH3 TEF4 TPD3 YBL104C YOR1 YRA1 ZDS1 ZDS2
    View Details Qiu et al. (2008) CIN1 RBL2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run PAN1 No Comments Toshima J, et al (2006)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data CIN1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..180] deduced N/A No confident structure predictions are available.
    2 View Details [181..452] MSA 11.013952 View MSA. No confident structure predictions are available.
    3 View Details [453..745] deduced N/A No confident structure predictions are available.
    4 View Details [746..1014] MSA 1.00287 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  1.4666436207573 bayes_pls_golite062009
  • protein binding
    		•  0.659303148960021 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.83

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle