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View Structure Prediction Details

Protein: CIN1
Organism: Saccharomyces cerevisiae
Length: 1014 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CIN1.

Description E-value Query
Range		 Subject
Range
gi|151945426 - gi|151945426|gb|EDN63669.1| tubulin folding cofactor D [Saccharomyces cerevisiae YJM789]
CIN1_YEAST - Chromosome instability protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CIN1 PE...
CIN1 - Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased...
 0.0 [1..1014] [1..1014]
gi|19113185 - gi|19113185|ref|NP_596393.1| hypothetical protein SPBC11C11.04c [Schizosaccharomyces pombe 972h-]
alp1 - tubulin specific chaperone cofactor D
 3.0E-66 [205..414] [258..486]
ALP1_SCHPO - Tubulin-folding cofactor D OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=alp1 PE=1 SV=2
gi|5915683, gi|1... - gi|5915683|sp|Q10197.2|ALP1_SCHPO RecName: Full=Tubulin-folding cofactor D; AltName: Full=Altered po...
 3.0E-66 [205..414] [258..486]
TBCD_BOVIN - Tubulin-specific chaperone D OS=Bos taurus GN=TBCD PE=1 SV=1
 9.0E-66 [231..414] [356..527]
TBCD_MOUSE - Tubulin-specific chaperone D OS=Mus musculus GN=Tbcd PE=1 SV=1
 1.0E-65 [234..414] [349..522]
gi|3850044 - gi|3850044|emb|CAA07022.1| beta-tubulin cofactor D [Homo sapiens]
 9.0E-65 [231..414] [349..520]

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Predicted Domain #1
Region A:
Residues: [1-180] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNNIRALLDS IQSGVQTVSP EKHQQTIAAI NKFQDDPALL DTILPRCVPL LTKSFFCMSQ  60
   61 RDQKLVAELF YNLDKISHSK VLKSLDTSIF RLNEILNYLQ DRASPSSFSD VLCVYLNLSW 120
  121 LSVILLSPYA FKDKFNKTLQ VSSRFENYPI CIPPINKIKA VLYFKNFTDA FDQLPEREQA 180
  181

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [181-452] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NVPFLNQFLK LFIQSSEKAN YYFSNENLRH LQQVALSNDG IKLLPKLFQI SFNHGSHDIL  60
   61 DAIVEFFHDH LSSNSTDTRF QLAHSFAKIA KFLHQADPAS FIELIDYTIE NTVSLLQAPC 120
  121 DSIDSNELHT SLLIIAEVAL AKILPIDLVD RVLTLIIPKT CHFQKSHFQI IKGHHIRDST 180
  181 NFIIWSVIRS NRSNSLSPQV LQSLLSHLLI NAFFDPELII RYSSFAALQE LLGRSNKSLA 240
  241 LNQNDIALIL QANWKDLPRS FEENSGLIRR LF

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
binding 1.4666436207573 bayes_pls_golite062009
protein binding 0.659303148960021 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [453-745] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NPENTSKSAV CVWKVFRDWS FNWNLLENLH LTTMKLNIDY NLVPLIKSKL SSPALLQEVL  60
   61 NKAGSSVTQN CQILYLYLKL FENDVNCPKI SEICIDIYQK KIKFQLTTQA KRQFNDNSPE 120
  121 LFQIFVILKY WQLTGQNDFN QELFWKFVDI VSPQKKLNLY NEFIPIIQQI ISQCVSLNYT 180
  181 RIVQLIKSDN ELTCRSICHM PDQEKMCSLF FSQFPLLSPQ SRSLLIGELD HHWDVRISLL 240
  241 PSNSYRKFRN IIINCLDDYT ITQQGDVGRL VRIQALKLMQ SHPDFLSGDC DSI

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [746-1014] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NPKLTRLLAE PVPEIRKLSY QLLASATSQI TVLSDSSILN FRHKQGLSEE FWKGYAVSAG  60
   61 AIHFTDSQLT SSIDSFIVYY RSLSPSQQLE LCHDLIRIIP SAKQIAESRI RDRNKDPLTG 120
  121 GMRFDTIKFT IHCVKFWTRI MESGLVVLHP NFNFQGVFAK FYNLHLLDCT TLRVSVIKFF 180
  181 PFLAISCYHT MRENADQKNL SNIILKRLLV LVKREYAATK SKFMTDQNVA LQGMFQIFLE 240
  241 LGVTRQLQAL QVACQKHELA NILESDITL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle