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Protein Overview: CPA1

General Information:
Name(s) found: CPA1 / YOR303W [SGD]
Description(s) found:
Found 28 descriptions.
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  • Small subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor; translationally regulated by an attenuator peptide encoded by YOR302W within the CPA1 mRNA 5'-leader [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 411 amino acids

    Gene Ontology:
    Cellular Component: carbamoyl-phosphate synthase complex [ISSLink to PubMed article]
    Biological Process: arginine biosynthetic process [TASLink to PubMed article]
    Molecular Function: carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSAATKATF CIQNGPSFEG ISFGANKSVA GETVFTTSLV GYPESMTDPS YRGQILVFTQ  60
   61 PLIGNYGVPS GEARDEYNLL KYFESPHIHV VGIVVAEYAY QYSHWTAVES LAQWCQREGV 120
  121 AAITGVDTRE LVQYLREQGS SLGRITLADH DPVPYVNPMK TNLVAQVTTK KPFHVSALPG 180
  181 KAKANVALID CGVKENIIRC LVKRGANVTV FPYDYRIQDV ASEFDGIFLS NGPGNPELCQ 240
  241 ATISNVRELL NNPVYDCIPI FGICLGHQLL ALASGASTHK LKYGNRAHNI PAMDLTTGQC 300
  301 HITSQNHGYA VDPETLPKDQ WKPYFVNLND KSNEGMIHLQ RPIFSTQFHP EAKGGPLDTA 360
  361 ILFDKFFDNI EKYQLQSQAK SSISLKVTYS TDKSRLQSIN VTKLAKERVL F

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CPA1 CPA2
    View Details (MIPS) Mewes HW, et al. (2004) CPA1 CPA2
    View Details Krogan NJ, et al. (2006) CPA1 CPA2 URA2
    View Details Ho Y, et al. (2002) ARO1 ARP2 CPA1 PRB1 PRP28 RNQ1 SWM1 TCB3 URA7

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen PPT1 CPA1 1 Unpublished Fields Lab Data
    View Screen UBC7 CPA1 1 Unpublished Fields Lab Data
    View Screen CLB2 CPA1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data CPA1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..158] PSI-BLAST 781.0 Carbamoyl phosphate synthetase, small subunit N-terminal domain; Carbamoyl phosphate synthetase, small subunit C-terminal domain
    2 View Details [159..411] PSI-BLAST 781.0 Carbamoyl phosphate synthetase, small subunit N-terminal domain; Carbamoyl phosphate synthetase, small subunit C-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
    		•  9.74519370915839 bayes_pls_golite062009
  • carbamoyl-phosphate synthase activity
    		•  9.70414577567935 bayes_pls_golite062009
  • carbon-nitrogen ligase activity, with glutamine as amido-N-donor
    		•  9.14496558670743 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  7.05319676113266 bayes_pls_golite062009
  • ligase activity
    		•  1.70348758031146 bayes_pls_golite062009
  • phosphoribosylformylglycinamidine synthase activity
    		•  1.51568729563523 bayes_pls_golite062009
  • catalytic activity
    		•  1.30391542469987 bayes_pls_golite062009
  • imidazoleglycerol-phosphate synthase activity
    		•  0.270391651600004 bayes_pls_golite062009
  • anthranilate synthase activity
    		•  0.243205818526006 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.12569720972861 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle