Protein Overview: WHI2

General Information:
Name(s) found:	WHI2 / YOR043W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6324617\|ref\|NP_014686.1\| Protein required, with binding partner Psr1p, for full activation of the general stress response, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression; [NCBI NR] gi\|2507156\|sp\|P12611.2\|WHI2_YEAST RecName: Full=Growth regulation protein [NCBI NR] pir\|\|COBYW2 WHI2 protein - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|1420169\|emb\|CAA99234.1\| WHI2 [Saccharomyces cerevisiae] [NCBI NR] Growth regulation protein OS=Saccharomyces cerevisiae GN=WHI2 PE=1 SV=2 [Swiss-Prot] WHI2 Growth regulation protein [mips] Protein required, with binding partner Psr1p, for full activation of the general stress response, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression [SGD] (P12611) Growth regulation protein [4932.FASTACCERV.txt] Chr XV from 410869-412329 [hmr_yeast5_DM3-1_pombe.fasta] WHI2, Chr XV from 410869-412329 [yeast_orfs2] WHI2 SGDID:S0005569, Chr XV from 410869-412329, Verified ORF [yeastflysequest.fasta] Protein required, with binding partner Psr1p, for full activation of the general stress response, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression [Saccharomyces cerevisiae]gi [nrdb_11152004_Chlamydomonas] WHI2 SGDID:S000005569, Chr XV from 410869-412329, Verified ORF, "Protein required, with binding partner Psr1p, for full activation of the general stress response, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negativ [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] WHI2 SGDID:S000005569, Chr XV from 410870-412330, Verified ORF, "Protein required, with binding partner Psr1p, for full activation of the general stress response, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negativ [yeast-contam.fasta] WHI2 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Protein required, with binding partner Psr1p, for full activation of the general stress response, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression; Whi2p [Saccharomyces cerevis [nr-271106-contam.fasta] Growth regulation protein [nr-271106-contam.fasta] WHI2 SGDID:S000005569, Chr XV from 410870-412330, Verified ORF, "Protein required, with binding partner Psr1p, for full activation of the general stress response, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression" [yeast-bovrabprots.fasta] [chemostatdb.fasta] Growth regulation protein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=WHI2 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] WHI2 SGDID:S000005569, Chr XV from 410870-412330, Genome Release 64-1-1, Verified ORF, "Protein required, with binding partner Psr1p, for full activation of the general stress response, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression" [yeast-030211-contam.fasta] WHI2 SGDID:S000005569, Chr XV from 410870-412330, Genome Release 64-2-1, Verified ORF, "Protein required for full activation of the general stress response; required with binding partner Psr1p, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression" [20141208_orf_trans.fasta] TR3563\|c0_g1_i1\|g.2555 ORF TR3563\|c0_g1_i1\|g.2555 TR3563\|c0_g1_i1\|m.2555 type:complete len:487 (+) TR3563\|c0_g1_i1:777-2237(+) [Y12_S_cerevisiae-Sep2015-contam.fasta] YOR043W SGDID:S000005569, Chr XV from 410870-412330, Genome Release 64-1-1, Verified ORF, "Protein required, with binding partner Psr1p, for full activation of the general stress response, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta] asmbl_2344\|g.1802 ORF asmbl_2344\|g.1802 asmbl_2344\|m.1802 type:complete len:487 (+) asmbl_2344:777-2237(+) [Y12_Trinity_v2_2_0_PASA_6May2016-contam.fasta] ID=asmbl_2347\|g.1519 ORF ID=asmbl_2347\|g.1519 ID=asmbl_2347\|m.1519 type:complete len:487 (+) ID=asmbl_2347:777-2237(+) [Y12_quiver_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
Organism:	Saccharomyces cerevisiae
Length:	486 amino acids
Gene Ontology:
Cellular Component:	cellular_component [ND]
Biological Process:	telomere maintenance [IMP] actin filament organization [IMP] endocytosis [IMP] regulation of growth [IMP] response to stress [TAS]
Molecular Function:	phosphatase activator activity [IMP][IPI]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDDIITQVSP DNAESAPILQ EQQQQQNSQY EGNEEDYGDS LIHLNIQENH YFITRDQLMS  60
   61 LPESLLLCLF PSGVFLDRCG QVITNLTRDD EVYIVNFPPD CFEYIMEIYT KAHDDLYNHP 120
  121 VEKFFDRPSS SFVSNAKGFF GLSSNNSISS NNEQDILHQK PAIIVLREDL DYYCVPQEEF 180
  181 QFDSTNEENN EDLLRHFMAQ VKMAAGSYLT SKTSIFQGLY SSNRLKQQQQ QQKIEKGSNS 240
  241 SSNTKSTSKK LGPAEQHLMD MLCSSGFTKE TCWGNRTQET GKTVISSLSL CRLANETTEG 300
  301 FRQKFNEAKA KWEAEHKPSQ DNFITPMQSN ISINSLSASK SNSTISTARN LTSGSTAPAT 360
  361 ARDKRKSRLS KLADNVRSHS SSRHSSQTRS KPPELPKLYD LVPKPNINAK LLLFWRKPAR 420
  421 KCWWGEEDIE LEVEVFGSWK DESKKIIELI LPTNVDPEAE LHKIIVPVRL HIRRVWTLEL 480
  481 SVIGVQ

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		PSR1 PSR2 WHI2
View Details	Krogan NJ, et al. (2006)		PSR1 PSR2 VHS2 WHI2
View Details	Ho Y, et al. (2002)		CSR2 HYP2 PSR1 WHI2

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	EUG1	WHI2	2	Unpublished Fields Lab Data
View Screen	UBC6	WHI2	1	Unpublished Fields Lab Data
View Screen	BOI2	WHI2	1	Unpublished Fields Lab Data
View Screen	UBP6	WHI2	1	Unpublished Fields Lab Data
View Screen	CKB1	WHI2	1	Unpublished Fields Lab Data
View Screen	FMP48	WHI2	1	Unpublished Fields Lab Data
View Screen	GIC1	WHI2	1	Unpublished Fields Lab Data
View Screen	SAM35	WHI2	1	Unpublished Fields Lab Data
View Screen	SKG6	WHI2	1	Unpublished Fields Lab Data
View Screen	UBC7	WHI2	1	Unpublished Fields Lab Data
View Screen	TPK2	WHI2	1	Unpublished Fields Lab Data
View Screen	CNS1	WHI2	1	Unpublished Fields Lab Data
View Screen	RAD9	WHI2	1	Unpublished Fields Lab Data
View Screen	PRP42	WHI2	1	Unpublished Fields Lab Data
View Screen	GIC2	WHI2	1	Unpublished Fields Lab Data
View Screen	FRQ1	WHI2	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	WHI2	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..309]	MSA	1.002914	View MSA. No confident structure predictions are available.
2	View Details	[310..486]	deduced	N/A	No confident structure predictions are available.
3	View Details	[313..391]	deduced	N/A	No confident structure predictions are available.
4	View Details	[392..486]	deduced	N/A	No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.98

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2