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Protein Overview: WHI2

General Information:
Name(s) found: WHI2 / YOR043W [SGD]
Description(s) found:
Found 26 descriptions.
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  • Protein required, with binding partner Psr1p, for full activation of the general stress response, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 486 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: telomere maintenance [IMPLink to PubMed article]
    actin filament organization [IMPLink to PubMed article]
    endocytosis [IMPLink to PubMed article]
    regulation of growth [IMPLink to PubMed article]
    response to stress [TASLink to PubMed article]
    Molecular Function: phosphatase activator activity [IMPLink to PubMed article][IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDDIITQVSP DNAESAPILQ EQQQQQNSQY EGNEEDYGDS LIHLNIQENH YFITRDQLMS  60
   61 LPESLLLCLF PSGVFLDRCG QVITNLTRDD EVYIVNFPPD CFEYIMEIYT KAHDDLYNHP 120
  121 VEKFFDRPSS SFVSNAKGFF GLSSNNSISS NNEQDILHQK PAIIVLREDL DYYCVPQEEF 180
  181 QFDSTNEENN EDLLRHFMAQ VKMAAGSYLT SKTSIFQGLY SSNRLKQQQQ QQKIEKGSNS 240
  241 SSNTKSTSKK LGPAEQHLMD MLCSSGFTKE TCWGNRTQET GKTVISSLSL CRLANETTEG 300
  301 FRQKFNEAKA KWEAEHKPSQ DNFITPMQSN ISINSLSASK SNSTISTARN LTSGSTAPAT 360
  361 ARDKRKSRLS KLADNVRSHS SSRHSSQTRS KPPELPKLYD LVPKPNINAK LLLFWRKPAR 420
  421 KCWWGEEDIE LEVEVFGSWK DESKKIIELI LPTNVDPEAE LHKIIVPVRL HIRRVWTLEL 480
  481 SVIGVQ

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) PSR1 PSR2 WHI2
    View Details Krogan NJ, et al. (2006) PSR1 PSR2 VHS2 WHI2
    View Details Ho Y, et al. (2002) CSR2 HYP2 PSR1 WHI2

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen EUG1 WHI2 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data WHI2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..309] MSA 1.002914 View MSA. No confident structure predictions are available.
    2 View Details [310..486] deduced N/A No confident structure predictions are available.
    3 View Details [313..391] deduced N/A No confident structure predictions are available.
    4 View Details [392..486] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle