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Protein Overview: UTP23

General Information:
Name(s) found: UTP23 / YOR004W [SGD]
Description(s) found:
Found 28 descriptions.
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  • Essential nucleolar protein that is a component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; has homology to PINc domain protein Fcf1p, although the PINc domain of Utp23p is not required for function [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 254 amino acids

    Gene Ontology:
    Cellular Component: small-subunit processome [IPILink to PubMed article]
    mitochondrion [IDALink to PubMed article]
    nuclear outer membrane [IMPLink to PubMed article]
    nucleolus [IDALink to PubMed articleLink to PubMed article]
    Biological Process: maturation of SSU-rRNA [IMPLink to PubMed article]
    ribosome biogenesis [RCALink to PubMed article]
    rRNA processing [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRQKRAKSYR KQLLVYSHTF KFREPYQVLV DNQLVLECNN SNFNLPSGLK RTLQADVKVM  60
   61 ITQCCIQALY ETRNDGAINL AKQFERRRCN HSFKDPKSPA ECIESVVNIS GANKHRYVVA 120
  121 SQDIDLRRKL RTVPGVPLIH LTRSVMVMEP LSTASAKASK ITEEQKLYKG LNDPNIEKLQ 180
  181 ESGDGSGKES ITKKRKLGPK APNPLSVKKK KKVNSPSDEV KDKEDTSKEK KKRRRRKHKS 240
  241 NTNVPVSNGT TAAQ

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) FCF1 IMP3 IMP4 MPP10 UTP23

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run UTP23 No Comments Hazbun TR, et al. (2003)
    View Run UTP23 No Comments Hazbun TR, et al. (2003)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data UTP23 and SPC42 Hazbun TR, et al. (2003)
    View Data UTP23 and SPC42 Unpublished Data
    View Data UTP23 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..198] MSA 24.037988 View MSA. No confident structure predictions are available.
    2 View Details [199..254] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • nuclease activity
    		•  2.9643999717473 bayes_pls_golite062009
  • exonuclease activity
    		•  2.73966722455965 bayes_pls_golite062009
  • endodeoxyribonuclease activity
    		•  2.32240591300465 bayes_pls_golite062009
  • deoxyribonuclease activity
    		•  2.20319910135606 bayes_pls_golite062009
  • DNA binding
    		•  2.08813762501061 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.94354032094901 bayes_pls_golite062009
  • flap endonuclease activity
    		•  1.93047867791632 bayes_pls_golite062009
  • binding
    		•  1.92045449238153 bayes_pls_golite062009
  • endonuclease activity
    		•  1.76157945742159 bayes_pls_golite062009
  • hydrolase activity
    		•  1.70203323769024 bayes_pls_golite062009
  • 5'-3' exonuclease activity
    		•  1.66809858159343 bayes_pls_golite062009
  • endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  1.5104333947608 bayes_pls_golite062009
  • catalytic activity
    		•  1.37534898662234 bayes_pls_golite062009
  • exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  1.24621366977274 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  1.0761952249864 bayes_pls_golite062009
  • exodeoxyribonuclease activity, producing 5'-phosphomonoesters
    		•  0.756864776606945 bayes_pls_golite062009
  • exodeoxyribonuclease activity
    		•  0.74826759322705 bayes_pls_golite062009
  • protein binding
    		•  0.696235153462548 bayes_pls_golite062009
  • 3'-5' exonuclease activity
    		•  0.50487165366129 bayes_pls_golite062009
  • 5'-3' exodeoxyribonuclease activity
    		•  0.34527101309477 bayes_pls_golite062009
  • double-stranded DNA specific exodeoxyribonuclease activity
    		•  0.123105804280941 bayes_pls_golite062009
  • single-stranded DNA specific exodeoxyribonuclease activity
    		•  0.120278857913627 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle