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Protein Overview: FCF1

General Information:
Name(s) found: FCF1 / YDR339C [SGD]
Description(s) found:
Found 32 descriptions.
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  • Putative PINc domain nuclease required for early cleavages of 35S pre-rRNA and maturation of 18S rRNA; component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; copurifies with Faf1p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 189 amino acids

    Gene Ontology:
    Cellular Component: small-subunit processome [IPILink to PubMed article]
    nuclear outer membrane [IMPLink to PubMed articleLink to PubMed article]
    nucleolus [IDALink to PubMed articleLink to PubMed article]
    Biological Process: mitochondrion organization [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGKAKKTRKF GLVKRTLNTK KDQRLKKNQE NIKTKEDPEL TRNIPQVSSA LFFQYNQAIK  60
   61 PPYQVLIDTN FINFSIQKKV DIVRGMMDCL LAKCNPLITD CVMAELEKLG PKYRIALKLA 120
  121 RDPRIKRLSC SHKGTYADDC LVHRVLQHKC YIVATNDAGL KQRIRKIPGI PLMSVGGHAY 180
  181 VIEKLPDVF

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) COR1 FCF1 PMC1
    View Details Qiu et al. (2008) FCF1 IMP3 IMP4 MPP10 UTP23

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data FCF1 and SPC42 Unpublished Data

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..189] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA binding
    		•  3.09371833630908 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.04560439515264 bayes_pls_golite062009
  • nuclease activity
    		•  2.9643999717473 bayes_pls_golite062009
  • exonuclease activity
    		•  2.73966722455965 bayes_pls_golite062009
  • endodeoxyribonuclease activity
    		•  2.32240591300465 bayes_pls_golite062009
  • deoxyribonuclease activity
    		•  2.20319910135606 bayes_pls_golite062009
  • binding
    		•  2.06833406478856 bayes_pls_golite062009
  • flap endonuclease activity
    		•  1.93047867791632 bayes_pls_golite062009
  • endonuclease activity
    		•  1.76157945742159 bayes_pls_golite062009
  • 5'-3' exonuclease activity
    		•  1.66809858159343 bayes_pls_golite062009
  • protein binding
    		•  1.53930087292625 bayes_pls_golite062009
  • endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  1.5104333947608 bayes_pls_golite062009
  • catalytic activity
    		•  1.37534898662234 bayes_pls_golite062009
  • exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  1.24621366977274 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  1.0761952249864 bayes_pls_golite062009
  • exodeoxyribonuclease activity, producing 5'-phosphomonoesters
    		•  0.756864776606945 bayes_pls_golite062009
  • exodeoxyribonuclease activity
    		•  0.74826759322705 bayes_pls_golite062009
  • 3'-5' exonuclease activity
    		•  0.50487165366129 bayes_pls_golite062009
  • 5'-3' exodeoxyribonuclease activity
    		•  0.34527101309477 bayes_pls_golite062009
  • double-stranded DNA specific exodeoxyribonuclease activity
    		•  0.123105804280941 bayes_pls_golite062009
  • single-stranded DNA specific exodeoxyribonuclease activity
    		•  0.120278857913627 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle