YRC Public Data Repository - Protein Structure Prediction

Protein:	FCF1
Organism:	Saccharomyces cerevisiae
Length:	189 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FCF1.

Description	E-value	Query Range	Subject Range
gi\|20197374, gi\|... - gi\|20197374\|gb\|AAC62883.2\| expressed protein [Arabidopsis thaliana], gi\|18407014\|ref\|NP_566068.1\| un...	2.0E-71	[1..188]	[1..188]
FCF1_PONAB - rRNA-processing protein FCF1 homolog OS=Pongo abelii GN=FCF1 PE=2 SV=1 gi\|109084315 - gi\|109084315\|ref\|XP_001088448.1\| PREDICTED: similar to Protein C14orf111 [Macaca mulatta] ENSCJAT00000040286 - null FCF1 - FCF1 small subunit (SSU) processome component homolog (S. cerevisiae) CN111_PONPY, FCF... - rRNA-processing protein FCF1 homolog - Pongo pygmaeus (Orangutan), (Q5RFQ0) Protein C14orf111 homolo... gi\|114653949 - gi\|114653949\|ref\|XP_522906.2\| PREDICTED: hypothetical protein [Pan troglodytes] FCF1_BOVIN - rRNA-processing protein FCF1 homolog OS=Bos taurus GN=FCF1 PE=2 SV=1	1.0E-66	[1..189]	[1..193]
FCF1_YEAST - rRNA-processing protein FCF1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FCF1 PE=1 S... FCF1 - Putative PINc domain nuclease required for early cleavages of 35S pre-rRNA and maturation of 18S rRN... gi\|207346429 - gi\|207346429\|gb\|EDZ72923.1\| YDR339Cp-like protein [Saccharomyces cerevisiae AWRI1631] gi\|190404720 - gi\|190404720\|gb\|EDV07987.1\| hypothetical protein SCRG_00190 [Saccharomyces cerevisiae RM11-1a]	3.0E-66	[1..189]	[1..189]
gi\|50293957, gi\|... - gi\|50293957\|ref\|XP_449390.1\| hypothetical protein CAGL0M01056g [Candida glabrata CBS138], gi\|4952870... gi\|15667240, gi\|... - gi\|49528704\|emb\|CAG62366.1\| unnamed protein product [Candida glabrata], gi\|15667240\|gb\|AAL02316.1\| Y...	6.0E-66	[1..189]	[1..189]
gi\|12834300 - gi\|12834300\|dbj\|BAB22857.1\| unnamed protein product [Mus musculus]	9.0E-64	[4..189]	[1..190]
FCF1_SCHPO - rRNA-processing protein fcf1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=fcf1 PE=3 SV=... SPBC32H8.04c - rRNA processing protein Fcf1	1.0E-58	[1..188]	[1..190]
gi\|220949042 - gi\|220949042\|gb\|ACL87064.1\| Bka-PA [synthetic construct] Bka-PA - The gene Bekka is referred to in FlyBase by the symbol Dmel\Bka (CG4539, FBgn0010520). It is a prote...	1.0E-56	[1..189]	[1..196]
CE09810 - Yeast D96591.6 protein like status:Confirmed UniProt:Q93638 protein_id:CAB03017.2	9.0E-55	[1..189]	[1..191]

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Predicted Domain #1

Region A:
Residues: [1-189]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGKAKKTRKF GLVKRTLNTK KDQRLKKNQE NIKTKEDPEL TRNIPQVSSA LFFQYNQAIK  60
   61 PPYQVLIDTN FINFSIQKKV DIVRGMMDCL LAKCNPLITD CVMAELEKLG PKYRIALKLA 120
  121 RDPRIKRLSC SHKGTYADDC LVHRVLQHKC YIVATNDAGL KQRIRKIPGI PLMSVGGHAY 180
  181 VIEKLPDVF

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Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
DNA binding	3.09371833630908	bayes_pls_golite062009
nucleic acid binding	3.04560439515264	bayes_pls_golite062009
nuclease activity	2.9643999717473	bayes_pls_golite062009
exonuclease activity	2.73966722455965	bayes_pls_golite062009
endodeoxyribonuclease activity	2.32240591300465	bayes_pls_golite062009
deoxyribonuclease activity	2.20319910135606	bayes_pls_golite062009
binding	2.06833406478856	bayes_pls_golite062009
flap endonuclease activity	1.93047867791632	bayes_pls_golite062009
endonuclease activity	1.76157945742159	bayes_pls_golite062009
5'-3' exonuclease activity	1.66809858159343	bayes_pls_golite062009
protein binding	1.53930087292625	bayes_pls_golite062009
endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	1.5104333947608	bayes_pls_golite062009
catalytic activity	1.37534898662234	bayes_pls_golite062009
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	1.24621366977274	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	1.0761952249864	bayes_pls_golite062009
exodeoxyribonuclease activity, producing 5'-phosphomonoesters	0.756864776606945	bayes_pls_golite062009
exodeoxyribonuclease activity	0.74826759322705	bayes_pls_golite062009
3'-5' exonuclease activity	0.50487165366129	bayes_pls_golite062009
5'-3' exodeoxyribonuclease activity	0.34527101309477	bayes_pls_golite062009
double-stranded DNA specific exodeoxyribonuclease activity	0.123105804280941	bayes_pls_golite062009
single-stranded DNA specific exodeoxyribonuclease activity	0.120278857913627	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: