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Protein Overview: MAM3

General Information:
Name(s) found: MAM3 / YOL060C [SGD]
Description(s) found:
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  • gi|984180|emb|CAA62524.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • gi|74627272|sp|Q12296.1|MAM3_YEAST RecName: Full=Protein MAM3 [NCBI NR]
  • gi|6324512|ref|NP_014581.1| Protein required for normal mitochondrial morphology, has similarity to hemolysins; Mam3p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|51013095|gb|AAT92841.1| YOL060C [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S61717 probable membrane protein YOL060c - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1419875|emb|CAA99069.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • Protein MAM3 OS=Saccharomyces cerevisiae GN=MAM3 PE=1 SV=1 [Swiss-Prot]
  • MAM3 Protein required for normal mitochondrial morphology [mips]
  • Protein required for normal mitochondrial morphology, has similarity to hemolysins [SGD]
  • >Q12296 (Q12296) Chromosome XV reading frame ORF YOL060C [4932.FASTACCERV.txt]
  • Chr XV from 216136-214016, reverse complement [hmr_yeast5_DM3-1_pombe.fasta]
  • Chr XV from 214016-216136, reverse complement [yeastorf3.fasta]
  • AMI3, Chr XV from 214016-216136, reverse complement [yeast_orfs2]
  • MAM3 SGDID:S0005421, Chr XV from 216136-214016, reverse complement, Verified ORF [yeastflysequest.fasta]
  • Mam3p [Saccharomyces cerevisiae]gi|51013095|gb|AAT92841.1| YOL060C [Saccharomyces cerevisiae]gi|984180|emb|CAA62524.1| unnamed protein product [Saccharomyces cerevisiae]gi|1419875|emb|CAA99069.1| unnamed protein product [Saccharomyces cerevisiae]gi|21 [nrdb_11152004_Chlamydomonas]
  • (Q12296) S.cerevisiae chromosome XV reading frame ORF YOL060c (S.cerevisiae DNA from chromosome XV) (contains gpd3, arg1, gpm3, sp2, gal11 genes) [cerv4932.FASTAC]
  • MAM3 SGDID:S000005421, Chr XV from 216136-214016, reverse complement, Verified ORF, "Protein required for normal mitochondrial morphology, has similarity to hemolysins" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • MAM3 SGDID:S000005421, Chr XV from 216137-214017, reverse complement, Verified ORF, "Protein required for normal mitochondrial morphology, has similarity to hemolysins" [yeast-contam.fasta]
  • YOL060C [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Protein required for normal mitochondrial morphology, has similarity to hemolysins; Mam3p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • Protein MAM3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MAM3 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • MAM3 SGDID:S000005421, Chr XV from 216137-214017, Genome Release 64-1-1, reverse complement, Verified ORF, "Protein required for normal mitochondrial morphology, has similarity to hemolysins" [yeast-030211-contam.fasta]
  • MAM3 SGDID:S000005421, Chr XV from 216137-214017, Genome Release 64-2-1, reverse complement, Verified ORF, "Protein required for normal mitochondrial morphology; has similarity to hemolysins" [20141208_orf_trans.fasta]
  • YOL060C SGDID:S000005421, Chr XV from 216137-214017, Genome Release 64-1-1, reverse complement, Verified ORF, "Protein required for normal mitochondrial morphology, has similarity to hemolysins" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 706 amino acids

    Gene Ontology:
    Cellular Component: fungal-type vacuole membrane [IDALink to PubMed article]
    Biological Process: cellular manganese ion homeostasis [IMPLink to PubMed article]
    mitochondrion organization [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFLPLRSRS RSGAPHWVYI ILYHIFTIPK IYSLPLLSGS HVLNSRDVAD SGHSVGDEAS  60
   61 VTTYYIISII LVLLGGVFAG LTLGLMGQDE VYLKVISTSG SNSEKKLAKR VLDLISRGKH 120
  121 WVLVTLLLSN VITNETLPIV LDRCLGGGWQ AVVSSTILIV IFGEIIPQSV CVKYGLQVGA 180
  181 FFCPFVLVLM YLMYPVAYPI ATLLDYMLGE DHGTMYKKSG LKTLVTLHRT MGVERLTKDE 240
  241 VTIISAVLDL KAKRVEEIMT PIENVFTMSA DTILDDKTVE KIFNSGFSRI PIFLPNEPNN 300
  301 FIGMLLVRVL ISYDPDDCLP ISHFPLATLP ETSPNTSCLN ILNYFQEGKA HMCVVSKEPG 360
  361 SSHGAIGVLT LEDVIEELIG EEIVDESDVF VDMHQHIMRQ QPGPLSKRHI TSYLHHLYTS 420
  421 SHKEHKAADQ ADESSPLLSP SNSNHPSEHP QQDLNNKSWK QKSNDGYDRS NAVLSPTPQV 480
  481 TEHGTIIPSN LASNPLNVNK SFVTIKKPAN VPKIITTHTP HSSKEPSPAP HSNDKSLSAE 540
  541 EQQLLSDHAE LSRQAVLHTQ RSGQPTQVTT STKTTRNSPD SISIPNSGAN HGNENQNVTI 600
  601 STSYQNTKNG IVESVITVKG VPKTIIGPAK DWDESKSEYG NENINQENSN RSDDRESSSS 660
  661 NASLFSSIKN KFKNENANNN DRSNFTDSLS RTSNYDANGS SSTIKR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run VAM3 Sample: HX11 - both fusion and trans-SNARE complex formation take place. Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control). Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX14 - mixture in detergent (control). Hao Xu, et al. (2010)
    View Run VAM3 hx21: both fusion and trans-SNARE complex formation take place. Investigating Vam3p, Nyv1p and their partners in trans-SNARE complex Hao Xu, et al. (2010)
    View Run VAM3 hx23: mixture in detergent (control) Investigating Vam3p, Nyv1p and their partners in trans-SNARE complex Hao Xu, et al. (2010)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen IOC2 MAM3 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data MAM3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..195] Pfam 28.251812 Domain of unknown function DUF21 No confident structure predictions are available.
    2 View Details [196..521] PSI-BLAST 34.522879 Inosine monophosphate dehydrogenase (IMPDH); Type II inosine monophosphate dehydrogenase
    3 View Details [522..706] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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